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- W2921978077 abstract "Cardiorenal syndrome (CRS) remains a global health burden with a lack of definitive and effective treatment. Protein-bound uremic toxin (PBUT) overload has been identified as a non-traditional risk factor for cardiac, renal and vascular dysfunction due to significant albumin-binding properties, rendering these solutes non-dialyzable upon the state of irreversible kidney dysfunction. Although limited, experimental studies have investigated possible mechanisms in PBUT-mediated cardiac, renal and vascular effects. The ultimate aim is to identify relevant and efficacious targets that may translate beneficial outcomes in disease models and eventually in the clinic. This review will expand on detailed knowledge on mechanisms involved in detrimental effects of PBUT, specifically affecting the heart, kidney and vasculature, and explore potential effective intracellular targets to abolish their effects in CRS initiation and/or progression." @default.
- W2921978077 created "2019-03-22" @default.
- W2921978077 creator A5016971767 @default.
- W2921978077 creator A5025400050 @default.
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- W2921978077 creator A5077985621 @default.
- W2921978077 creator A5079928639 @default.
- W2921978077 creator A5082008789 @default.
- W2921978077 date "2019-06-01" @default.
- W2921978077 modified "2023-09-24" @default.
- W2921978077 title "Molecular mechanisms of protein-bound uremic toxin-mediated cardiac, renal and vascular effects: underpinning intracellular targets for cardiorenal syndrome therapy" @default.
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