Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921989482> ?p ?o ?g. }
- W2921989482 endingPage "433" @default.
- W2921989482 startingPage "420" @default.
- W2921989482 abstract "Obsessive-compulsive disorder (OCD) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS) have been implicated. The present study aims to systematically review the literature for quantitative evidence that patients with OCD have altered measures of blood O&NS markers.Independent random-effects meta-analyses using standardized mean differences were conducted to assess each marker separately. Additionally, data from multiple markers were pooled together in a meta-analysis for measures of oxidant activity and another for measures of antioxidant activity.Thirteen studies met inclusion criteria, involving 433 OCD patients and 459 controls. Eleven blood O&NS markers were eligible for independent quantitative analyses. We found that, in OCD patients, the oxidant markers 8-hydroxydeoxyguanosine and malondialdehyde, and the antioxidants glutathione peroxidase and superoxide dismutase, were significantly increased while total antioxidant status, vitamin C, and vitamin E were significantly decreased, when comparing with controls. Regarding pooled meta-analyses, we found a statistically significant increase in oxidant markers, but non-significant results regarding antioxidant markers.Our meta-analysis suggests that OCD patients have a systemic oxidative imbalance that is not adequately buffered by the antioxidant system. Additional studies are needed in order to support this association." @default.
- W2921989482 created "2019-03-22" @default.
- W2921989482 creator A5011677404 @default.
- W2921989482 creator A5012847374 @default.
- W2921989482 creator A5019635962 @default.
- W2921989482 creator A5032763144 @default.
- W2921989482 creator A5043863759 @default.
- W2921989482 creator A5047065171 @default.
- W2921989482 creator A5071617604 @default.
- W2921989482 date "2019-04-09" @default.
- W2921989482 modified "2023-10-18" @default.
- W2921989482 title "Oxidative and nitrosative stress markers in obsessive–compulsive disorder: a systematic review and meta‐analysis" @default.
- W2921989482 cites W1640123358 @default.
- W2921989482 cites W1921153043 @default.
- W2921989482 cites W1925486158 @default.
- W2921989482 cites W1955944566 @default.
- W2921989482 cites W1970240791 @default.
- W2921989482 cites W1970774237 @default.
- W2921989482 cites W1971990056 @default.
- W2921989482 cites W1976950210 @default.
- W2921989482 cites W1981818131 @default.
- W2921989482 cites W1983472283 @default.
- W2921989482 cites W1985438873 @default.
- W2921989482 cites W1986677774 @default.
- W2921989482 cites W1986683334 @default.
- W2921989482 cites W1992261726 @default.
- W2921989482 cites W1995305184 @default.
- W2921989482 cites W1997727568 @default.
- W2921989482 cites W1998700858 @default.
- W2921989482 cites W2000048861 @default.
- W2921989482 cites W2002182743 @default.
- W2921989482 cites W2002922196 @default.
- W2921989482 cites W2004396558 @default.
- W2921989482 cites W2005904867 @default.
- W2921989482 cites W2011136740 @default.
- W2921989482 cites W2018143147 @default.
- W2921989482 cites W2020463921 @default.
- W2921989482 cites W2026977189 @default.
- W2921989482 cites W2033007699 @default.
- W2921989482 cites W2035528400 @default.
- W2921989482 cites W2035661416 @default.
- W2921989482 cites W2040106357 @default.
- W2921989482 cites W2045589399 @default.
- W2921989482 cites W2050560433 @default.
- W2921989482 cites W2052454735 @default.
- W2921989482 cites W2053687646 @default.
- W2921989482 cites W2060038783 @default.
- W2921989482 cites W2060312436 @default.
- W2921989482 cites W2070680955 @default.
- W2921989482 cites W2077772283 @default.
- W2921989482 cites W2081109098 @default.
- W2921989482 cites W2083798699 @default.
- W2921989482 cites W2084947835 @default.
- W2921989482 cites W2085128660 @default.
- W2921989482 cites W2085390182 @default.
- W2921989482 cites W2088786819 @default.
- W2921989482 cites W2092148974 @default.
- W2921989482 cites W2100861230 @default.
- W2921989482 cites W2105160377 @default.
- W2921989482 cites W2107328434 @default.
- W2921989482 cites W2115871409 @default.
- W2921989482 cites W2116003431 @default.
- W2921989482 cites W2120423982 @default.
- W2921989482 cites W2121945096 @default.
- W2921989482 cites W2122150468 @default.
- W2921989482 cites W2123822033 @default.
- W2921989482 cites W2128473487 @default.
- W2921989482 cites W2129770390 @default.
- W2921989482 cites W2131671310 @default.
- W2921989482 cites W2139131794 @default.
- W2921989482 cites W2142072174 @default.
- W2921989482 cites W2147802796 @default.
- W2921989482 cites W2151735632 @default.
- W2921989482 cites W2157823046 @default.
- W2921989482 cites W2166526741 @default.
- W2921989482 cites W2167929603 @default.
- W2921989482 cites W2170634352 @default.
- W2921989482 cites W2198359636 @default.
- W2921989482 cites W2250305518 @default.
- W2921989482 cites W2296033150 @default.
- W2921989482 cites W2300880694 @default.
- W2921989482 cites W2313558199 @default.
- W2921989482 cites W2316769012 @default.
- W2921989482 cites W2318600546 @default.
- W2921989482 cites W2334177155 @default.
- W2921989482 cites W2341683692 @default.
- W2921989482 cites W2412363222 @default.
- W2921989482 cites W2530760382 @default.
- W2921989482 cites W2592865134 @default.
- W2921989482 cites W2746276856 @default.
- W2921989482 cites W2793397878 @default.
- W2921989482 cites W2802830659 @default.
- W2921989482 cites W4247665917 @default.
- W2921989482 cites W4294215472 @default.
- W2921989482 doi "https://doi.org/10.1111/acps.13026" @default.
- W2921989482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30873609" @default.
- W2921989482 hasPublicationYear "2019" @default.
- W2921989482 type Work @default.