FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2921994823> ?p ?o ?g. }

• W2921994823 endingPage "S1630" @default.
• W2921994823 startingPage "S1630" @default.
• W2921994823 abstract "Anaplastic thyroid carcinoma (ATC) is a rare, aggressive form of thyroid malignancy with a dismal prognosis regardless of treatment. Most patients present with symptoms including a rapidly expanding central neck mass, dysphagia, hoarseness, and stridor. Metastasis is found in approximately 50% of patients at time of diagnosis. Gastrointestinal metastasis of thyroid carcinoma is exceedingly rare. We report a case of thyroid malignancy metastasizing to the esophagus. A 78-year-old woman with history of unknown thyroid malignancy treated in Mexico with thyroidectomy as well as radiation and radioactive iodine, presented with weight loss, night sweats, cough, hoarseness and dysphagia for solids. Two years prior to development of these symptoms imaging revealed several lung nodules. Repeat imaging revealed a large esophageal mass. EGD revealed a near obstructing lesion in the proximal esophagus, 3 cm from the oropharynx. Biopsy revealed anaplastic carcinoma of thyroid origin with osteoclast-like giant cells. Molecular testing was positive for BRAF mutation. PET CT scan demonstrated uptake in the esophagus, lungs, and the right retropharyngeal area. The patient was referred to a cancer center for evaluation of potential treatment options. Thyroid cancer accounts for almost 3% of all malignancies, of which ATC comprises only 1-2%. It accounts for more than half of deaths from thyroid cancer with a mortality rate over 90%. It occurs most frequently in elderly females. Most metastasis involves the lungs, bone, and brain. Gastrointestinal malignancies of ATC are very rare and have only been reported in a small number of case reports. BRAF mutations, such as the one found in our patient are found in both papillary (27.3-87.1%) and anaplastic thyroid cancers (25%). Several case reports demonstrate that patients with papillary thyroid cancer can have an aggressive transformation to anaplastic malignancy, such as what we believe occurred in our patient as two years passed between initial cancer diagnosis and recurrence, as well as the presence of BRAF mutation. Limited treatment options exist but have very poor results. Doxorubicin and cisplatin have been used as chemotherapeutic options for many years. New therapies are focused on paclitaxel plus platinum therapy. As most patients present with advanced disease, treatment options are often focused on palliative surgical measures to reduce airway obstruction, followed by chemo-radiotherapy.2961_A Figure 1. Needle core biopsy of left neck mass showing neoplasm with osteoclast-like giant cells, favoring anaplastic carcinoma of thyroid origin2961_B Figure 2. CT chest with and without contrast demonstrating a large superior mediastinal, esophageal mass measuring 66 x 40 x 27 mm2961_C Figure 3. EGD demonstrating a near obstructing lesion in the proximal esophagus, 3 cm from the oropharynx" @default.
• W2921994823 created "2019-03-22" @default.
• W2921994823 creator A5041939129 @default.
• W2921994823 creator A5053177643 @default.
• W2921994823 creator A5056003774 @default.
• W2921994823 creator A5060031004 @default.
• W2921994823 creator A5071687777 @default.
• W2921994823 date "2018-10-01" @default.
• W2921994823 modified "2023-09-27" @default.
• W2921994823 title "Anaplastic Thyroid Cancer Metastasizing to the Esophagus" @default.
• W2921994823 doi "https://doi.org/10.14309/00000434-201810001-02960" @default.
• W2921994823 hasPublicationYear "2018" @default.
• W2921994823 type Work @default.
• W2921994823 sameAs 2921994823 @default.
• W2921994823 citedByCount "0" @default.
• W2921994823 crossrefType "journal-article" @default.
• W2921994823 hasAuthorship W2921994823A5041939129 @default.
• W2921994823 hasAuthorship W2921994823A5053177643 @default.
• W2921994823 hasAuthorship W2921994823A5056003774 @default.
• W2921994823 hasAuthorship W2921994823A5060031004 @default.
• W2921994823 hasAuthorship W2921994823A5071687777 @default.
• W2921994823 hasConcept C121608353 @default.
• W2921994823 hasConcept C126322002 @default.
• W2921994823 hasConcept C126838900 @default.
• W2921994823 hasConcept C142724271 @default.
• W2921994823 hasConcept C2777819096 @default.
• W2921994823 hasConcept C2779399171 @default.
• W2921994823 hasConcept C2779761222 @default.
• W2921994823 hasConcept C2779768787 @default.
• W2921994823 hasConcept C2780256643 @default.
• W2921994823 hasConcept C2780596822 @default.
• W2921994823 hasConcept C2993294228 @default.
• W2921994823 hasConcept C526584372 @default.
• W2921994823 hasConcept C71924100 @default.
• W2921994823 hasConceptScore W2921994823C121608353 @default.
• W2921994823 hasConceptScore W2921994823C126322002 @default.
• W2921994823 hasConceptScore W2921994823C126838900 @default.
• W2921994823 hasConceptScore W2921994823C142724271 @default.
• W2921994823 hasConceptScore W2921994823C2777819096 @default.
• W2921994823 hasConceptScore W2921994823C2779399171 @default.
• W2921994823 hasConceptScore W2921994823C2779761222 @default.
• W2921994823 hasConceptScore W2921994823C2779768787 @default.
• W2921994823 hasConceptScore W2921994823C2780256643 @default.
• W2921994823 hasConceptScore W2921994823C2780596822 @default.
• W2921994823 hasConceptScore W2921994823C2993294228 @default.
• W2921994823 hasConceptScore W2921994823C526584372 @default.
• W2921994823 hasConceptScore W2921994823C71924100 @default.
• W2921994823 hasIssue "Supplement" @default.
• W2921994823 hasLocation W29219948231 @default.
• W2921994823 hasOpenAccess W2921994823 @default.
• W2921994823 hasPrimaryLocation W29219948231 @default.
• W2921994823 hasRelatedWork W1965928838 @default.
• W2921994823 hasRelatedWork W2014435840 @default.
• W2921994823 hasRelatedWork W2090830622 @default.
• W2921994823 hasRelatedWork W2207625178 @default.
• W2921994823 hasRelatedWork W2316609919 @default.
• W2921994823 hasRelatedWork W2572623634 @default.
• W2921994823 hasRelatedWork W2583782264 @default.
• W2921994823 hasRelatedWork W2902148150 @default.
• W2921994823 hasRelatedWork W3034704098 @default.
• W2921994823 hasRelatedWork W3162532703 @default.
• W2921994823 hasVolume "113" @default.
• W2921994823 isParatext "false" @default.
• W2921994823 isRetracted "false" @default.
• W2921994823 magId "2921994823" @default.
• W2921994823 workType "article" @default.