Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922008085> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2922008085 endingPage "101" @default.
- W2922008085 startingPage "93" @default.
- W2922008085 abstract "Non-targeted small molecule screening methods are used to analyze samples for potential compounds of interest without focusing on specific molecular species. There is great interest in these methods for metabolomic, environmental, forensic, and food safety applications, among others, to determine compounds that are responsible for a particular disease state or the presence of a harmful compound. In order for non-targeted analyses to become standardized and routine, best practices for sample preparation, data collection, and data analysis must be determined. This work focuses on optimizing specific aspects of a non-targeted workflow that utilizes high-resolution mass spectrometry using an Orbitrap instrument coupled to liquid chromatography. Sample preparation, liquid chromatography gradient length, and mass spectrometry resolving power and ionization modes were investigated to determine optimal conditions for detecting and extracting compounds from the data that cover broad molecular and polarity ranges. Infant rice cereal, orange juice, and yogurt with spiked standards were analyzed; food is inherently challenging to analyze due in part to sample complexity and diversity. Of the conditions tested, optimal conditions included a generic sample extraction using acetonitrile, water, and formic acid, a 25 min chromatographic gradient, collecting data in both positive and negative ion modes, and using 70 k resolving power. There are of course tradeoffs associated with each of these options that will be described in detail so that the appropriate conditions can be chosen for the desired application." @default.
- W2922008085 created "2019-03-22" @default.
- W2922008085 creator A5019334985 @default.
- W2922008085 creator A5065747957 @default.
- W2922008085 creator A5088943824 @default.
- W2922008085 date "2019-08-01" @default.
- W2922008085 modified "2023-09-29" @default.
- W2922008085 title "Optimized chemical coverage and data quality for non-targeted screening applications using liquid chromatography/high-resolution mass spectrometry" @default.
- W2922008085 cites W1264092346 @default.
- W2922008085 cites W1886668606 @default.
- W2922008085 cites W1893216948 @default.
- W2922008085 cites W1972516621 @default.
- W2922008085 cites W1978747976 @default.
- W2922008085 cites W1979597489 @default.
- W2922008085 cites W1987238342 @default.
- W2922008085 cites W1995782945 @default.
- W2922008085 cites W2020848465 @default.
- W2922008085 cites W2030611954 @default.
- W2922008085 cites W2040846139 @default.
- W2922008085 cites W2048888574 @default.
- W2922008085 cites W2060871758 @default.
- W2922008085 cites W2078212878 @default.
- W2922008085 cites W2112806519 @default.
- W2922008085 cites W2128473659 @default.
- W2922008085 cites W2134571812 @default.
- W2922008085 cites W2289913428 @default.
- W2922008085 cites W2317897169 @default.
- W2922008085 cites W2516722909 @default.
- W2922008085 cites W2554267795 @default.
- W2922008085 cites W2566602058 @default.
- W2922008085 doi "https://doi.org/10.1016/j.aca.2019.03.032" @default.
- W2922008085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31027538" @default.
- W2922008085 hasPublicationYear "2019" @default.
- W2922008085 type Work @default.
- W2922008085 sameAs 2922008085 @default.
- W2922008085 citedByCount "28" @default.
- W2922008085 countsByYear W29220080852019 @default.
- W2922008085 countsByYear W29220080852020 @default.
- W2922008085 countsByYear W29220080852021 @default.
- W2922008085 countsByYear W29220080852022 @default.
- W2922008085 countsByYear W29220080852023 @default.
- W2922008085 crossrefType "journal-article" @default.
- W2922008085 hasAuthorship W2922008085A5019334985 @default.
- W2922008085 hasAuthorship W2922008085A5065747957 @default.
- W2922008085 hasAuthorship W2922008085A5088943824 @default.
- W2922008085 hasConcept C113196181 @default.
- W2922008085 hasConcept C138268822 @default.
- W2922008085 hasConcept C154945302 @default.
- W2922008085 hasConcept C162356407 @default.
- W2922008085 hasConcept C185592680 @default.
- W2922008085 hasConcept C2777379063 @default.
- W2922008085 hasConcept C2778576202 @default.
- W2922008085 hasConcept C2780841973 @default.
- W2922008085 hasConcept C41008148 @default.
- W2922008085 hasConcept C43617362 @default.
- W2922008085 hasConceptScore W2922008085C113196181 @default.
- W2922008085 hasConceptScore W2922008085C138268822 @default.
- W2922008085 hasConceptScore W2922008085C154945302 @default.
- W2922008085 hasConceptScore W2922008085C162356407 @default.
- W2922008085 hasConceptScore W2922008085C185592680 @default.
- W2922008085 hasConceptScore W2922008085C2777379063 @default.
- W2922008085 hasConceptScore W2922008085C2778576202 @default.
- W2922008085 hasConceptScore W2922008085C2780841973 @default.
- W2922008085 hasConceptScore W2922008085C41008148 @default.
- W2922008085 hasConceptScore W2922008085C43617362 @default.
- W2922008085 hasLocation W29220080851 @default.
- W2922008085 hasLocation W29220080852 @default.
- W2922008085 hasOpenAccess W2922008085 @default.
- W2922008085 hasPrimaryLocation W29220080851 @default.
- W2922008085 hasRelatedWork W1966156295 @default.
- W2922008085 hasRelatedWork W1972516621 @default.
- W2922008085 hasRelatedWork W2028531314 @default.
- W2922008085 hasRelatedWork W2056321531 @default.
- W2922008085 hasRelatedWork W2143063110 @default.
- W2922008085 hasRelatedWork W2190459521 @default.
- W2922008085 hasRelatedWork W2371154968 @default.
- W2922008085 hasRelatedWork W2571641922 @default.
- W2922008085 hasRelatedWork W2917323430 @default.
- W2922008085 hasRelatedWork W2963860120 @default.
- W2922008085 hasVolume "1066" @default.
- W2922008085 isParatext "false" @default.
- W2922008085 isRetracted "false" @default.
- W2922008085 magId "2922008085" @default.
- W2922008085 workType "article" @default.