FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922022013> ?p ?o ?g. }

• W2922022013 abstract "In the present study, the effect of recombinant human bone morphogenetic protein‑2 (rhBMP‑2) delivered by chitosan (CS) microspheres on ectopic osteogenesis was investigated in a rat model. rhBMP‑2‑loaded CS microspheres and blank CS microspheres were prepared. A total of 24 male Sprague Dawley rats were divided into 4 groups with 6 rats in each group: The CS/rhBMP‑2 group, the rhBMP‑2 group, in which rhBMP‑2 was directly implanted (rhBMP‑2 dose in either group, 1 mg), the CS blank group and the control group. X‑ray was performed at 4 weeks after ectopic osteogenesis surgery and micro‑computed tomography (CT) examination was scheduled at 1, 2, 3 and 4 weeks after the surgery to determine ectopic osteogenesis in the different groups. Histological analysis, and determination of alkaline phosphatase (ALP) activity and calcium content were also performed. The mean diameter of the osteoid tissues was 1.1±0.3 cm (range, 0.8‑1.4 cm) in the CS/rhBMP‑2 group, which was significantly bigger than that in the rhBMP‑2 group (0.3±0.1 cm; range, 0.1‑0.4 cm) at 4 weeks after the surgery. X‑ray analysis and micro‑CT scan indicated that the area of high‑density tissues and the radionuclide intensity, as well as bone volume in the 3‑dimensional reconstruction were greatest in the CS/rhBMP‑2 group, followed by those in the rhBMP‑2 group. All parameters, including bone mineral density, tissue mineral density, tissue mineral content and bone volume fraction, were significantly higher in the CS/rhBMP‑2 group at 3 and 4 weeks after the surgery, compared with those in the rhBMP‑2 group. The histological analysis, ALP activity analysis and determination of calcium content revealed that the CS/rhBMP‑2 system had the greatest ability to induce osteoblast differentiation. In conclusion, the CS/rhBMP‑2 microsphere delivery system significantly enhanced the induction and promotion effects of rhBMP‑2 regarding ectopic osteogenesis. The present study enhances the basic data available for future application of the CS/rhBMP‑2 microspheres delivery system and provides a deeper understanding of the role of BMP‑2 in bone regeneration." @default.
• W2922022013 created "2019-03-22" @default.
• W2922022013 creator A5001753331 @default.
• W2922022013 creator A5038564887 @default.
• W2922022013 creator A5042973046 @default.
• W2922022013 creator A5043868957 @default.
• W2922022013 creator A5058255671 @default.
• W2922022013 creator A5060636544 @default.
• W2922022013 creator A5064317688 @default.
• W2922022013 creator A5069183135 @default.
• W2922022013 date "2019-03-18" @default.
• W2922022013 modified "2023-10-07" @default.
• W2922022013 title "Effect of recombinant human bone morphogenetic protein delivered by chitosan microspheres on ectopic osteogenesis in rats" @default.
• W2922022013 cites W1579672847 @default.
• W2922022013 cites W1969758467 @default.
• W2922022013 cites W1971435839 @default.
• W2922022013 cites W1983387751 @default.
• W2922022013 cites W2003433953 @default.
• W2922022013 cites W2012613966 @default.
• W2922022013 cites W2015757465 @default.
• W2922022013 cites W2070650602 @default.
• W2922022013 cites W2072527711 @default.
• W2922022013 cites W2088189657 @default.
• W2922022013 cites W2106909688 @default.
• W2922022013 cites W2107547390 @default.
• W2922022013 cites W2118089919 @default.
• W2922022013 cites W2120799429 @default.
• W2922022013 cites W2139586508 @default.
• W2922022013 cites W2142361560 @default.
• W2922022013 cites W2151135848 @default.
• W2922022013 cites W2171443849 @default.
• W2922022013 cites W2324339637 @default.
• W2922022013 cites W2327117475 @default.
• W2922022013 cites W2328511796 @default.
• W2922022013 cites W2529491176 @default.
• W2922022013 cites W2562744783 @default.
• W2922022013 cites W2606254366 @default.
• W2922022013 cites W2617423029 @default.
• W2922022013 cites W2623277425 @default.
• W2922022013 cites W2791384561 @default.
• W2922022013 doi "https://doi.org/10.3892/etm.2019.7406" @default.
• W2922022013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6447930" @default.
• W2922022013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30988773" @default.
• W2922022013 hasPublicationYear "2019" @default.
• W2922022013 type Work @default.
• W2922022013 sameAs 2922022013 @default.
• W2922022013 citedByCount "2" @default.
• W2922022013 countsByYear W29220220132022 @default.
• W2922022013 countsByYear W29220220132023 @default.
• W2922022013 crossrefType "journal-article" @default.
• W2922022013 hasAuthorship W2922022013A5001753331 @default.
• W2922022013 hasAuthorship W2922022013A5038564887 @default.
• W2922022013 hasAuthorship W2922022013A5042973046 @default.
• W2922022013 hasAuthorship W2922022013A5043868957 @default.
• W2922022013 hasAuthorship W2922022013A5058255671 @default.
• W2922022013 hasAuthorship W2922022013A5060636544 @default.
• W2922022013 hasAuthorship W2922022013A5064317688 @default.
• W2922022013 hasAuthorship W2922022013A5069183135 @default.
• W2922022013 hasBestOaLocation W29220220131 @default.
• W2922022013 hasConcept C104317684 @default.
• W2922022013 hasConcept C126322002 @default.
• W2922022013 hasConcept C126894567 @default.
• W2922022013 hasConcept C141071460 @default.
• W2922022013 hasConcept C160160445 @default.
• W2922022013 hasConcept C181199279 @default.
• W2922022013 hasConcept C185592680 @default.
• W2922022013 hasConcept C199343813 @default.
• W2922022013 hasConcept C202751555 @default.
• W2922022013 hasConcept C2776337968 @default.
• W2922022013 hasConcept C2776541429 @default.
• W2922022013 hasConcept C2776886416 @default.
• W2922022013 hasConcept C2779329777 @default.
• W2922022013 hasConcept C2779732960 @default.
• W2922022013 hasConcept C2989005 @default.
• W2922022013 hasConcept C2993373878 @default.
• W2922022013 hasConcept C30352789 @default.
• W2922022013 hasConcept C31507581 @default.
• W2922022013 hasConcept C40767141 @default.
• W2922022013 hasConcept C55493867 @default.
• W2922022013 hasConcept C71924100 @default.
• W2922022013 hasConcept C81880429 @default.
• W2922022013 hasConceptScore W2922022013C104317684 @default.
• W2922022013 hasConceptScore W2922022013C126322002 @default.
• W2922022013 hasConceptScore W2922022013C126894567 @default.
• W2922022013 hasConceptScore W2922022013C141071460 @default.
• W2922022013 hasConceptScore W2922022013C160160445 @default.
• W2922022013 hasConceptScore W2922022013C181199279 @default.
• W2922022013 hasConceptScore W2922022013C185592680 @default.
• W2922022013 hasConceptScore W2922022013C199343813 @default.
• W2922022013 hasConceptScore W2922022013C202751555 @default.
• W2922022013 hasConceptScore W2922022013C2776337968 @default.
• W2922022013 hasConceptScore W2922022013C2776541429 @default.
• W2922022013 hasConceptScore W2922022013C2776886416 @default.
• W2922022013 hasConceptScore W2922022013C2779329777 @default.
• W2922022013 hasConceptScore W2922022013C2779732960 @default.
• W2922022013 hasConceptScore W2922022013C2989005 @default.
• W2922022013 hasConceptScore W2922022013C2993373878 @default.
• W2922022013 hasConceptScore W2922022013C30352789 @default.
• W2922022013 hasConceptScore W2922022013C31507581 @default.
• W2922022013 hasConceptScore W2922022013C40767141 @default.

• next