FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922044450> ?p ?o ?g. }

• W2922044450 endingPage "142" @default.
• W2922044450 startingPage "123" @default.
• W2922044450 abstract "With the increase in knowledge resulting from the sequencing of the human genome, the genetic basis for the underlying differences in individuals, their diseases, and how they respond to therapies is starting to be understood. This has formed the foundation for the era of precision medicine in many human diseases that is beginning to be implemented in the clinic, particularly in cancer. However, preclinical testing of therapeutic approaches based on individual biology will need to be validated in animal models prior to translation into patients. Although animal models, particularly murine models, have provided significant information on the basic biology underlying immune responses in various diseases and the response to therapy, murine and human immune systems differ markedly. These fundamental differences may be the underlying reason why many of the positive therapeutic responses observed in mice have not translated directly into the clinic. There is a critical need for preclinical animal models in which human immune responses can be investigated. For this, many investigators are using humanized mice, i.e., immunodeficient mice engrafted with functional human cells, tissues, and immune systems. We will briefly review the history of humanized mice, the remaining limitations, approaches to overcome them and how humanized mouse models are being used as a preclinical bridge in precision medicine for evaluation of human therapies prior to their implementation in the clinic." @default.
• W2922044450 created "2019-03-22" @default.
• W2922044450 creator A5020731444 @default.
• W2922044450 creator A5022634163 @default.
• W2922044450 creator A5023032912 @default.
• W2922044450 creator A5030432595 @default.
• W2922044450 creator A5033226354 @default.
• W2922044450 creator A5036394378 @default.
• W2922044450 creator A5081336918 @default.
• W2922044450 date "2019-03-07" @default.
• W2922044450 modified "2023-10-17" @default.
• W2922044450 title "Humanized mouse models of immunological diseases and precision medicine" @default.
• W2922044450 cites W1489484572 @default.
• W2922044450 cites W1533839222 @default.
• W2922044450 cites W1535950095 @default.
• W2922044450 cites W1552274890 @default.
• W2922044450 cites W1595298938 @default.
• W2922044450 cites W1601405552 @default.
• W2922044450 cites W1922016811 @default.
• W2922044450 cites W1952297410 @default.
• W2922044450 cites W1965550894 @default.
• W2922044450 cites W1970910239 @default.
• W2922044450 cites W1971704900 @default.
• W2922044450 cites W1972044265 @default.
• W2922044450 cites W1974196749 @default.
• W2922044450 cites W1977533863 @default.
• W2922044450 cites W1984295407 @default.
• W2922044450 cites W1987111799 @default.
• W2922044450 cites W1988078074 @default.
• W2922044450 cites W1989877475 @default.
• W2922044450 cites W1995249775 @default.
• W2922044450 cites W1995363983 @default.
• W2922044450 cites W1999253174 @default.
• W2922044450 cites W2001128436 @default.
• W2922044450 cites W2001775594 @default.
• W2922044450 cites W2002220495 @default.
• W2922044450 cites W2003466425 @default.
• W2922044450 cites W2006496065 @default.
• W2922044450 cites W2007987850 @default.
• W2922044450 cites W2008630922 @default.
• W2922044450 cites W2010519150 @default.
• W2922044450 cites W2017760463 @default.
• W2922044450 cites W2019060582 @default.
• W2922044450 cites W2021186851 @default.
• W2922044450 cites W2021802250 @default.
• W2922044450 cites W2025835234 @default.
• W2922044450 cites W2031700674 @default.
• W2922044450 cites W2034540804 @default.
• W2922044450 cites W2034632639 @default.
• W2922044450 cites W2040207288 @default.
• W2922044450 cites W2041515126 @default.
• W2922044450 cites W2046560815 @default.
• W2922044450 cites W2047579315 @default.
• W2922044450 cites W2048524126 @default.
• W2922044450 cites W2053926251 @default.
• W2922044450 cites W2060196382 @default.
• W2922044450 cites W2060423622 @default.
• W2922044450 cites W2064645845 @default.
• W2922044450 cites W2067114333 @default.
• W2922044450 cites W2067194336 @default.
• W2922044450 cites W2067850941 @default.
• W2922044450 cites W2070597700 @default.
• W2922044450 cites W2071843728 @default.
• W2922044450 cites W2072803960 @default.
• W2922044450 cites W2073489229 @default.
• W2922044450 cites W2076582857 @default.
• W2922044450 cites W2079218392 @default.
• W2922044450 cites W2090489211 @default.
• W2922044450 cites W2090857531 @default.
• W2922044450 cites W2092194665 @default.
• W2922044450 cites W2095293156 @default.
• W2922044450 cites W2098900183 @default.
• W2922044450 cites W2099761180 @default.
• W2922044450 cites W2101758099 @default.
• W2922044450 cites W2109491705 @default.
• W2922044450 cites W2109963121 @default.
• W2922044450 cites W2114530568 @default.
• W2922044450 cites W2114949839 @default.
• W2922044450 cites W2116062123 @default.
• W2922044450 cites W2128367413 @default.
• W2922044450 cites W2129714576 @default.
• W2922044450 cites W2130191021 @default.
• W2922044450 cites W2136706405 @default.
• W2922044450 cites W2137187071 @default.
• W2922044450 cites W2137906256 @default.
• W2922044450 cites W2138726422 @default.
• W2922044450 cites W2141989396 @default.
• W2922044450 cites W2144155263 @default.
• W2922044450 cites W2144980184 @default.
• W2922044450 cites W2145237269 @default.
• W2922044450 cites W2145254159 @default.
• W2922044450 cites W2148890861 @default.
• W2922044450 cites W2149130444 @default.
• W2922044450 cites W2149551002 @default.
• W2922044450 cites W2149929061 @default.
• W2922044450 cites W2161771297 @default.
• W2922044450 cites W2165450990 @default.
• W2922044450 cites W2166045197 @default.

• next