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- W2922058219 abstract "Introduction: Hand grip strength is a simple and non-invasive measure for frailty and pre-frailty in aging populations. It has been shown to predict cardiovascular disease events, disability, fracture risk, and all-cause mortality. However, the biological pathways underlying frailty remain largely unknown. Hypothesis: Serum metabolites may associate with grip strength, among a middle aged biracial population. Methods: Untargeted ultrahigh performance liquid chromatography-tandem mass spectroscopy was used to detect and quantify serum metabolites among 825 white and 436 African-American participants of the Bogalusa Heart Study. Grip strength was measured in kg, and was averaged between both hands. We used race stratified and combined multivariate adjusted linear regression to examine associations between single metabolites and grip strength (mean: 35.14 kg, standard deviation: 11.85 kg), adjusted for age, sex, body mass index, kidney function, education, cigarette smoking, alcohol drinking, and race (in combined analyses). Significant metabolites were identified as those achieving Bonferroni corrected significance (P<4.16х10 -5 ) in one race group and the entire cohort, with a similar trend observed in the other race group. Results: Six novel associated metabolites were identified, comprised of amino acid (polyamine), carbohydrate (aminosugar), and nucleotide (purine metabolism, adenine containing, and pyrimidine metabolism, cytidine or uracil containing) subpathways ( Table ). Participants with higher levels of these metabolites had lower grip strength. Conclusions: This analysis identified novel metabolites associated with grip strength, providing insight into the biological pathways of frailty." @default.
- W2922058219 created "2019-03-22" @default.
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- W2922058219 date "2019-03-05" @default.
- W2922058219 modified "2023-09-24" @default.
- W2922058219 title "Abstract P020: Novel Serum Metabolites Associate With Grip Strength Among Bogalusa Heart Study Participants" @default.
- W2922058219 doi "https://doi.org/10.1161/circ.139.suppl_1.p020" @default.
- W2922058219 hasPublicationYear "2019" @default.
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