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- W2922076665 abstract "Abstract Objectives Neuropsychiatric symptoms (NPS) are common among individuals with dementia of the Alzheimer’s type (DAT). We sought to characterize which NPS more purely relate to cognitive dysfunction in DAT, relative to other NPS. Method Demographic, neurocognitive, neuroimaging, and NPS data were mined from the Alzheimer’s Disease Neuroimaging Initiative database (n = 906). Using factor analysis, we analyzed the degree to which individual NPS were associated with DAT-associated cognitive dysfunction. We also employed item response theory to graphically depict the ability of individual NPS to index DAT-associated cognitive dysfunction across a continuum ranging from cognitively normal to mild DAT. Results Psychotic symptoms (hallucinations and delusions) were more strongly related to the continuum of DAT-associated cognitive dysfunction than other NPS, with the strength of the relationship peaking at high levels of disease severity. Psychotic symptoms also negatively correlated with brain volume and did not relate to the presence of vision problems. Aberrant motor behavior and apathy had relatively smaller associations with DAT-associated cognitive dysfunction, while other NPS showed minimal associations. Discussion Psychotic symptoms most strongly indexed DAT-associated cognitive dysfunction, whereas other NPS, such as depression and anxiety, were not as precisely related to the DAT-associated cognitive dysfunction." @default.
- W2922076665 created "2019-03-22" @default.
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- W2922076665 date "2019-04-16" @default.
- W2922076665 modified "2023-10-18" @default.
- W2922076665 title "Hallucinations and Delusions Signal Alzheimer’s Associated Cognitive Dysfunction More Strongly Compared to Other Neuropsychiatric Symptoms" @default.
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- W2922076665 doi "https://doi.org/10.1093/geronb/gbz032" @default.
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