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• W2922087323 abstract "Abstract Acromegaly is a rare disease resulting from hypersecretion of growth hormone ( GH ) and insulin‐like growth factor 1 ( IGF 1) typically caused by pituitary adenomas, which is associated with increased mortality and morbidity. Somatostatin analogues ( SSA s) represent the primary medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy after unsuccessful pituitary surgery. However, a considerable proportion of patients do not adequately respond to SSA s treatment, and therefore, there is an urgent need to identify biomarkers predictors of response to SSA s. The aim of this study was to examine E‐cadherin expression by immunohistochemistry in fifty‐five GH ‐producing pituitary tumours and determine the potential association with response to SSA s as well as other clinical and histopathological features. Acromegaly patients with tumours expressing low E‐cadherin levels exhibit a worse response to SSA s. E‐cadherin levels are associated with GH ‐producing tumour histological subtypes. Our results indicate that the immunohistochemical detection of E‐cadherin might be useful in categorizing acromegaly patients based on the response to SSA s." @default.
• W2922087323 created "2019-03-22" @default.
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• W2922087323 date "2019-03-06" @default.
• W2922087323 modified "2023-10-15" @default.
• W2922087323 title "E‐cadherin expression is associated with somatostatin analogue response in acromegaly" @default.
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• W2922087323 doi "https://doi.org/10.1111/jcmm.13851" @default.
• W2922087323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6484433" @default.
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