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- W2922096999 startingPage "3636" @default.
- W2922096999 abstract "C-6α and C-7α androstanes were studied to disclose which position among them is more convenient to functionalize to reach superior aromatase inhibition. In the first series, the study of C-6 versus C-7 methyl derivatives led to the very active compound 9 with IC50 of 0.06 μM and Ki = 0.025 μM (competitive inhibition). In the second series, the study of C-6 versus C-7 allyl derivatives led to the best aromatase inhibitor 13 of this work with IC50 of 0.055 μM and Ki = 0.0225 μM (irreversible inhibition). Beyond these findings, it was concluded that position C-6α is better to functionalize than C-7α, except when there is a C-4 substituent simultaneously. In addition, the methyl group was the best substituent, followed by the allyl group and next by the hydroxyl group. To rationalize the structure–activity relationship of the best inhibitor 13, molecular modeling studies were carried out." @default.
- W2922096999 created "2019-03-22" @default.
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- W2922096999 date "2019-03-09" @default.
- W2922096999 modified "2023-10-14" @default.
- W2922096999 title "C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure–Activity Relationships" @default.
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- W2922096999 doi "https://doi.org/10.1021/acs.jmedchem.9b00157" @default.
- W2922096999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30852901" @default.