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• W2922110623 abstract "This paper discusses the biotechnological process affected by means of plant suspension cultures, for production of colchicoside, the 3- O-glucosyl derivative of 3- O-demethylcolchicine. Colchicoside can be considered as an antitumoural prodrug which is activated after oral administration and may have more beneficial effects and a better toxicity profile (because of a slow-release effect) than colchicine. We have developed a green and efficient biotechnological method using colchicine, as a precursor, derived from its natural source G. superba seeds. Plant suspension cultures of Astragalus vesicarius were used to design a practical biotechnological platform to replace a methyl group at C-3 regiospecifically by a glycosyl moiety in colchicine. Using different concentrations of a colchicine-rich extract, the maximum enzymatic potential of Astragalus vesicarius suspension cells was achieved. According to quantitative HPLC-UV analysis, levels of 9.35 μmol/g DW colchicoside were achieved. This is the first report of region-specific glycosylation at C-3 of the aromatic ring A of the colchicine using plant suspension cultures." @default.
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• W2922110623 date "2019-01-01" @default.
• W2922110623 modified "2023-09-26" @default.
• W2922110623 title "Biotransformation to Produce the Anticancer Compound Colchicoside Using Cell Suspension Cultures of <i>Astragalus vesicarius</i> Plant Species" @default.
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• W2922110623 doi "https://doi.org/10.1177/1934578x1901400108" @default.
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