Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922111330> ?p ?o ?g. }
- W2922111330 endingPage "3779" @default.
- W2922111330 startingPage "3773" @default.
- W2922111330 abstract "Protein N-terminal methyltransferase 1 (NTMT1) plays an important role in regulating mitosis and DNA repair. Here, we describe the discovery of a potent NTMT1 bisubstrate inhibitor 4 (IC50 = 35 ± 2 nM) that exhibits greater than 100-fold selectivity against a panel of methyltransferases. We also report the first crystal structure of NTMT1 in complex with an inhibitor, which revealed that 4 occupies substrate and cofactor binding sites of NTMT1." @default.
- W2922111330 created "2019-03-22" @default.
- W2922111330 creator A5017853072 @default.
- W2922111330 creator A5025586692 @default.
- W2922111330 creator A5029259654 @default.
- W2922111330 creator A5056368645 @default.
- W2922111330 date "2019-03-18" @default.
- W2922111330 modified "2023-10-18" @default.
- W2922111330 title "Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1" @default.
- W2922111330 cites W1484889816 @default.
- W2922111330 cites W1529363181 @default.
- W2922111330 cites W1620051969 @default.
- W2922111330 cites W1964575804 @default.
- W2922111330 cites W1964704790 @default.
- W2922111330 cites W1975747878 @default.
- W2922111330 cites W1990740058 @default.
- W2922111330 cites W1993976172 @default.
- W2922111330 cites W1999664351 @default.
- W2922111330 cites W2003960419 @default.
- W2922111330 cites W2005799364 @default.
- W2922111330 cites W2011770588 @default.
- W2922111330 cites W2023106521 @default.
- W2922111330 cites W2031188801 @default.
- W2922111330 cites W2031488347 @default.
- W2922111330 cites W2048637577 @default.
- W2922111330 cites W2051515034 @default.
- W2922111330 cites W2057487902 @default.
- W2922111330 cites W2058326352 @default.
- W2922111330 cites W2080597633 @default.
- W2922111330 cites W2080851722 @default.
- W2922111330 cites W2087839363 @default.
- W2922111330 cites W2165869149 @default.
- W2922111330 cites W2178878751 @default.
- W2922111330 cites W2239258558 @default.
- W2922111330 cites W2594215638 @default.
- W2922111330 cites W2737322106 @default.
- W2922111330 cites W2782747552 @default.
- W2922111330 cites W2903076801 @default.
- W2922111330 cites W2952893198 @default.
- W2922111330 doi "https://doi.org/10.1021/acs.jmedchem.9b00206" @default.
- W2922111330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6760264" @default.
- W2922111330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30883119" @default.
- W2922111330 hasPublicationYear "2019" @default.
- W2922111330 type Work @default.
- W2922111330 sameAs 2922111330 @default.
- W2922111330 citedByCount "27" @default.
- W2922111330 countsByYear W29221113302019 @default.
- W2922111330 countsByYear W29221113302020 @default.
- W2922111330 countsByYear W29221113302021 @default.
- W2922111330 countsByYear W29221113302022 @default.
- W2922111330 countsByYear W29221113302023 @default.
- W2922111330 crossrefType "journal-article" @default.
- W2922111330 hasAuthorship W2922111330A5017853072 @default.
- W2922111330 hasAuthorship W2922111330A5025586692 @default.
- W2922111330 hasAuthorship W2922111330A5029259654 @default.
- W2922111330 hasAuthorship W2922111330A5056368645 @default.
- W2922111330 hasBestOaLocation W29221113302 @default.
- W2922111330 hasConcept C181199279 @default.
- W2922111330 hasConcept C185592680 @default.
- W2922111330 hasConcept C197957613 @default.
- W2922111330 hasConcept C2776376580 @default.
- W2922111330 hasConcept C2776980637 @default.
- W2922111330 hasConcept C33288867 @default.
- W2922111330 hasConcept C552990157 @default.
- W2922111330 hasConcept C55493867 @default.
- W2922111330 hasConcept C71240020 @default.
- W2922111330 hasConcept C74187038 @default.
- W2922111330 hasConcept C91965660 @default.
- W2922111330 hasConceptScore W2922111330C181199279 @default.
- W2922111330 hasConceptScore W2922111330C185592680 @default.
- W2922111330 hasConceptScore W2922111330C197957613 @default.
- W2922111330 hasConceptScore W2922111330C2776376580 @default.
- W2922111330 hasConceptScore W2922111330C2776980637 @default.
- W2922111330 hasConceptScore W2922111330C33288867 @default.
- W2922111330 hasConceptScore W2922111330C552990157 @default.
- W2922111330 hasConceptScore W2922111330C55493867 @default.
- W2922111330 hasConceptScore W2922111330C71240020 @default.
- W2922111330 hasConceptScore W2922111330C74187038 @default.
- W2922111330 hasConceptScore W2922111330C91965660 @default.
- W2922111330 hasFunder F4320333206 @default.
- W2922111330 hasIssue "7" @default.
- W2922111330 hasLocation W29221113301 @default.
- W2922111330 hasLocation W29221113302 @default.
- W2922111330 hasLocation W29221113303 @default.
- W2922111330 hasLocation W29221113304 @default.
- W2922111330 hasOpenAccess W2922111330 @default.
- W2922111330 hasPrimaryLocation W29221113301 @default.
- W2922111330 hasRelatedWork W1164537646 @default.
- W2922111330 hasRelatedWork W1543965807 @default.
- W2922111330 hasRelatedWork W169735115 @default.
- W2922111330 hasRelatedWork W1790834371 @default.
- W2922111330 hasRelatedWork W2080203695 @default.
- W2922111330 hasRelatedWork W2084240653 @default.
- W2922111330 hasRelatedWork W2170874906 @default.
- W2922111330 hasRelatedWork W2811032335 @default.
- W2922111330 hasRelatedWork W3131469594 @default.
- W2922111330 hasRelatedWork W966738943 @default.
- W2922111330 hasVolume "62" @default.