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• W2922120134 abstract "Abstract Recent advances in neurogenetics have highlighted Drosophila melanogaste r as an exciting model to study neural circuit dynamics and complex behavior. Automated tracking methods have facilitated the study of complex behaviors via high throughput behavioral screening. Here we describe a newly developed low-cost assay capable of real-time monitoring and quantifying Drosophila group activity. This platform offers reliable real-time quantification with open source software and a user-friendly interface for data acquisition and analysis. We demonstrate the utility of this platform by characterizing ethanol-induced locomotor activity in a dose-dependent manner as well as the effects of thermo and optogenetic manipulation of ellipsoid body neurons important for ethanol-induced locomotor activity. As expected, low doses of ethanol induced an initial startle and slow ramping of group activity, whereas high doses of ethanol induced sustained group activity followed by sedation. Advanced offline processing revealed discrete behavioral features characteristic of intoxication. Thermogenetic inactivation of ellipsoid body ring neurons reduced group activity whereas optogenetic activation increased activity. Together, these data establish the f ly G roup A ctivity M onitor (flyGrAM) platform as a robust means of obtaining an online read out of group activity in response to manipulations to the environment or neural activity, with an opportunity for more advanced post-processing offline." @default.
• W2922120134 created "2019-03-22" @default.
• W2922120134 creator A5030785047 @default.
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• W2922120134 date "2019-03-14" @default.
• W2922120134 modified "2023-10-14" @default.
• W2922120134 title "Automated real-time quantification of group locomotor activity in Drosophila melanogaster" @default.
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• W2922120134 doi "https://doi.org/10.1038/s41598-019-40952-5" @default.
• W2922120134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6418093" @default.
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• W2922120134 hasPublicationYear "2019" @default.
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