Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922123721> ?p ?o ?g. }
- W2922123721 endingPage "684" @default.
- W2922123721 startingPage "675" @default.
- W2922123721 abstract "Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydrogen peroxide (H 2 O 2 ) in endothelial cells. In order to find the IC 50 of H 2 O 2 and the protective dose of vulpinic acid, methyl thiazolyldiphenyl tetrazolium bromide (MTT) assays were performed. The amount of reactive oxygen species (ROS) induced by H 2 O 2 and the protective effects of vulpinic acid against ROS were examined by fluorometric DCF-DA kit. The effects of H 2 O 2 and vulpinic acid on actin filaments were determined by tetramethyl rhodamine (TRITC)-phalloidin fluorescence staining. Expression of Tie2 proteins was immunocytochemically analyzed in H 2 O 2 - and vulpinic acid-treated cells. After 24 h, the IC 50 was found to be 215 μM in HUVECs treated with H 2 O 2 . The most effective dose of vulpinic acid against H 2 O 2 -associated damage was found to be 15 μM. Vulpinic acid pretreatment was shown to reduce H 2 O 2 -induced ROS production significantly ( p < 0.05). It was shown that 215 μM of H 2 O 2 caused actin fragmentation, cell shrinkage, and decrease in actin florescence intensity while vulpinic acid protected the cells from these damages. It was found that Tie2 immunoreactivity was decreased in H 2 O 2 -treated groups and vulpinic acid pretreatment reduced the expression of this protein. In conclusion, vulpinic acid decreases H 2 O 2 -induced oxidative stress and oxidative stress–related damages in HUVECs. It may be drug candidate in the therapy of atherosclerosis." @default.
- W2922123721 created "2019-03-22" @default.
- W2922123721 creator A5005564730 @default.
- W2922123721 creator A5008279027 @default.
- W2922123721 creator A5026737372 @default.
- W2922123721 creator A5083973607 @default.
- W2922123721 creator A5089129259 @default.
- W2922123721 creator A5091495979 @default.
- W2922123721 date "2019-03-14" @default.
- W2922123721 modified "2023-10-18" @default.
- W2922123721 title "Vulpinic acid, a lichen metabolite, emerges as a potential drug candidate in the therapy of oxidative stress–related diseases, such as atherosclerosis" @default.
- W2922123721 cites W1970661675 @default.
- W2922123721 cites W1972438525 @default.
- W2922123721 cites W1985556486 @default.
- W2922123721 cites W2000900078 @default.
- W2922123721 cites W2004099321 @default.
- W2922123721 cites W2007176877 @default.
- W2922123721 cites W2025114395 @default.
- W2922123721 cites W2027654334 @default.
- W2922123721 cites W2036272335 @default.
- W2922123721 cites W2061517844 @default.
- W2922123721 cites W2093147113 @default.
- W2922123721 cites W2115318369 @default.
- W2922123721 cites W2116714591 @default.
- W2922123721 cites W2123077733 @default.
- W2922123721 cites W2130040661 @default.
- W2922123721 cites W2141832516 @default.
- W2922123721 cites W2184499518 @default.
- W2922123721 cites W2189269492 @default.
- W2922123721 cites W2222530691 @default.
- W2922123721 cites W2258925661 @default.
- W2922123721 cites W2275204317 @default.
- W2922123721 cites W2319279358 @default.
- W2922123721 cites W2322409733 @default.
- W2922123721 cites W2337556126 @default.
- W2922123721 cites W2346078141 @default.
- W2922123721 cites W2550344090 @default.
- W2922123721 cites W2561846699 @default.
- W2922123721 cites W2738556201 @default.
- W2922123721 cites W2755249976 @default.
- W2922123721 cites W2783270031 @default.
- W2922123721 cites W2784864514 @default.
- W2922123721 cites W2790384338 @default.
- W2922123721 cites W2796403010 @default.
- W2922123721 cites W2805949211 @default.
- W2922123721 cites W4302988378 @default.
- W2922123721 doi "https://doi.org/10.1177/0960327119833745" @default.
- W2922123721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30868920" @default.
- W2922123721 hasPublicationYear "2019" @default.
- W2922123721 type Work @default.
- W2922123721 sameAs 2922123721 @default.
- W2922123721 citedByCount "15" @default.
- W2922123721 countsByYear W29221237212019 @default.
- W2922123721 countsByYear W29221237212020 @default.
- W2922123721 countsByYear W29221237212021 @default.
- W2922123721 countsByYear W29221237212022 @default.
- W2922123721 countsByYear W29221237212023 @default.
- W2922123721 crossrefType "journal-article" @default.
- W2922123721 hasAuthorship W2922123721A5005564730 @default.
- W2922123721 hasAuthorship W2922123721A5008279027 @default.
- W2922123721 hasAuthorship W2922123721A5026737372 @default.
- W2922123721 hasAuthorship W2922123721A5083973607 @default.
- W2922123721 hasAuthorship W2922123721A5089129259 @default.
- W2922123721 hasAuthorship W2922123721A5091495979 @default.
- W2922123721 hasConcept C153911025 @default.
- W2922123721 hasConcept C185592680 @default.
- W2922123721 hasConcept C18903297 @default.
- W2922123721 hasConcept C191015642 @default.
- W2922123721 hasConcept C2776151105 @default.
- W2922123721 hasConcept C2777477808 @default.
- W2922123721 hasConcept C2778004101 @default.
- W2922123721 hasConcept C48349386 @default.
- W2922123721 hasConcept C533411734 @default.
- W2922123721 hasConcept C55493867 @default.
- W2922123721 hasConcept C86803240 @default.
- W2922123721 hasConcept C98274493 @default.
- W2922123721 hasConceptScore W2922123721C153911025 @default.
- W2922123721 hasConceptScore W2922123721C185592680 @default.
- W2922123721 hasConceptScore W2922123721C18903297 @default.
- W2922123721 hasConceptScore W2922123721C191015642 @default.
- W2922123721 hasConceptScore W2922123721C2776151105 @default.
- W2922123721 hasConceptScore W2922123721C2777477808 @default.
- W2922123721 hasConceptScore W2922123721C2778004101 @default.
- W2922123721 hasConceptScore W2922123721C48349386 @default.
- W2922123721 hasConceptScore W2922123721C533411734 @default.
- W2922123721 hasConceptScore W2922123721C55493867 @default.
- W2922123721 hasConceptScore W2922123721C86803240 @default.
- W2922123721 hasConceptScore W2922123721C98274493 @default.
- W2922123721 hasIssue "6" @default.
- W2922123721 hasLocation W29221237211 @default.
- W2922123721 hasLocation W29221237212 @default.
- W2922123721 hasOpenAccess W2922123721 @default.
- W2922123721 hasPrimaryLocation W29221237211 @default.
- W2922123721 hasRelatedWork W1490540217 @default.
- W2922123721 hasRelatedWork W2190837461 @default.
- W2922123721 hasRelatedWork W2313463101 @default.
- W2922123721 hasRelatedWork W2368772701 @default.
- W2922123721 hasRelatedWork W2381884082 @default.