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- W2922126409 abstract "Photodynamic Therapy (PDT) with methyl-aminolevulinate acid (MAL-PDT) is being used for the treatment of Basal cell carcinoma (BCC), but recurrences have been reported. In this work, we have evaluated resistance mechanisms to MAL-PDT developed by three BCC cell lines (ASZ, BSZ and CSZ), derived from mice on a ptch+/- background and with or without p53 expression, subjected to 10 cycles of PDT (10thG). The resistant populations showed mesenchymal-like structure and diminished proliferative capacity and size compared to the parental (P) cells. The resistance was dependent on the production of the endogenous photosensitiser protoporphyrin IX in the CSZ cell line and on its cellular localisation in ASZ and BSZ cells. Moreover, resistant cells expressing the p53 gene presented lower proliferation rate and increased expression levels of N-cadherin and Gsk3β (a component of the Wnt/β-catenin pathway) than P cells. In contrast, 10thG cells lacking the p53 gene showed lower levels of expression of Gsk3β in the cytoplasm and of E-cadherin and β-catenin in the membrane. In addition, resistant cells presented higher tumorigenic ability in immunosuppressed mice. Altogether, these results shed light on resistance mechanisms of BCC to PDT and may help to improve the use of this therapeutic approach." @default.
- W2922126409 created "2019-03-22" @default.
- W2922126409 creator A5001995847 @default.
- W2922126409 creator A5008020114 @default.
- W2922126409 creator A5016288140 @default.
- W2922126409 creator A5030232429 @default.
- W2922126409 creator A5048330635 @default.
- W2922126409 creator A5055227388 @default.
- W2922126409 creator A5062003020 @default.
- W2922126409 creator A5064935365 @default.
- W2922126409 creator A5074828007 @default.
- W2922126409 date "2019-03-18" @default.
- W2922126409 modified "2023-10-16" @default.
- W2922126409 title "Characterisation of resistance mechanisms developed by basal cell carcinoma cells in response to repeated cycles of Photodynamic Therapy" @default.
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