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- W2922127739 abstract "Abstract Conventional drug therapies suffer from several limitations most prominently the pharmacokinetic alterations in biological systems, which result in decreased bioavailability at the desired location within the body. Furthermore, the undesired distribution, biotransformation, and elimination cause serious toxicities and submaximal therapeutic efficacy. The notion for targeted drug delivery systems (TDDS) thus emerged to limit these consequences and exaggerate the therapeutic value of the medicine by enhancing the concentration of drug in the desired tissue and simultaneous restriction to achieve lower concentration in the remaining body tissues. This improves efficacy of the drug while reducing side effects. The goal of TDDS is to deliver the drug molecule specifically to the desired site. In today’s era the advancements in the technologies have paved the way for searching the complex mechanisms within the cell and different organs to facilitate drug targeting. This chapter shall discuss about the complex cellular environments, biochemical signaling pathways, and regulatory biomechanisms that govern the movement of drug molecules and it shall also discuss the carriers or vehicles that carry the drug to specific locations within the body and physically modulate components. For better understanding of the reader, biophysical, physiochemical, stoichiometric, and pharmacological parameters affecting the stay and fate of drug molecules at delivery site shall also be discussed. Furthermore, the chapter shall also convey information about the research updates in this field of study and the advancements in the approaches that have developed from the beginning of the era of targeted drug delivery as well as future opportunities." @default.
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- W2922127739 date "2019-01-01" @default.
- W2922127739 modified "2023-09-24" @default.
- W2922127739 title "Cell and organ drug targeting" @default.
- W2922127739 doi "https://doi.org/10.1016/b978-0-12-816505-8.00015-1" @default.
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