FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922130736> ?p ?o ?g. }

• W2922130736 endingPage "1267" @default.
• W2922130736 startingPage "1259" @default.
• W2922130736 abstract "Objective. We evaluated the effect of sarilumab on patient-perceived impact of rheumatoid arthritis (RA) using the 7-domain RA Impact of Disease (RAID) scale. Methods. Two phase III, randomized, controlled trials of sarilumab in patients with active, longstanding RA were analyzed: (1) sarilumab 150 mg and 200 mg every 2 weeks plus conventional synthetic disease-modifying antirheumatic drugs (+csDMARD) versus placebo + csDMARD [TARGET ( NCT01709578 )]; and (2) sarilumab 200 mg versus adalimumab (ADA) 40 mg monotherapy [MONARCH ( NCT02332590 )]. Least-squares mean (LSM) differences in RAID total score (range 0–10) and 7 key RA symptoms, including pain and fatigue (baseline to Weeks 12 and 24), were compared. “Responders” by RAID total score were defined by improvements from baseline ≥ minimal clinically important difference (MCID), and ≥ patient-acceptable symptom-state (PASS) at endpoint. Results. Sarilumab 150 mg and 200 mg + csDMARD were nominally superior (p < 0.05) versus placebo + csDMARD and 200 mg sarilumab versus ADA 40 mg in LSM differences for RAID total score at weeks 12 (−0.93 and −1.13; −0.49, respectively) and 24 (−0.75 and −1.01; −0.78), and all effects of RA (except functional impairment in MONARCH Week 12). Effects were greater in physical domains (e.g., pain) than mental domains (e.g., emotional well-being). More patients receiving sarilumab versus placebo or ADA reported improvements ≥ MCID and PASS in total RAID scores at both assessments. Conclusion. Based on the RAID, sarilumab + csDMARD or as monotherapy reduced the effect of RA on patients’ lives to a greater extent than placebo + csDMARD or ADA monotherapy. ( ClinicalTrials.gov : NCT01709578 and NCT02332590 )" @default.
• W2922130736 created "2019-03-22" @default.
• W2922130736 creator A5004560391 @default.
• W2922130736 creator A5009151561 @default.
• W2922130736 creator A5012283576 @default.
• W2922130736 creator A5016395117 @default.
• W2922130736 creator A5029781530 @default.
• W2922130736 creator A5033861263 @default.
• W2922130736 creator A5042476895 @default.
• W2922130736 creator A5069919512 @default.
• W2922130736 creator A5091895459 @default.
• W2922130736 date "2019-03-15" @default.
• W2922130736 modified "2023-10-16" @default.
• W2922130736 title "Effects of Sarilumab on Rheumatoid Arthritis as Reported by Patients Using the Rheumatoid Arthritis Impact of Disease Scale" @default.
• W2922130736 cites W1984974372 @default.
• W2922130736 cites W1985004174 @default.
• W2922130736 cites W1986604569 @default.
• W2922130736 cites W2007409332 @default.
• W2922130736 cites W2020888702 @default.
• W2922130736 cites W2033262426 @default.
• W2922130736 cites W2033299724 @default.
• W2922130736 cites W2040963445 @default.
• W2922130736 cites W2080619574 @default.
• W2922130736 cites W2081734937 @default.
• W2922130736 cites W2091055562 @default.
• W2922130736 cites W2104389209 @default.
• W2922130736 cites W2124433729 @default.
• W2922130736 cites W2128952811 @default.
• W2922130736 cites W2129543954 @default.
• W2922130736 cites W2138323507 @default.
• W2922130736 cites W2139629261 @default.
• W2922130736 cites W2155496437 @default.
• W2922130736 cites W2156271885 @default.
• W2922130736 cites W2218158692 @default.
• W2922130736 cites W2266142224 @default.
• W2922130736 cites W2319089505 @default.
• W2922130736 cites W2549509332 @default.
• W2922130736 cites W2557016092 @default.
• W2922130736 cites W2562384286 @default.
• W2922130736 cites W2582143364 @default.
• W2922130736 cites W2593835974 @default.
• W2922130736 cites W2619068848 @default.
• W2922130736 cites W2625745683 @default.
• W2922130736 cites W2766796109 @default.
• W2922130736 cites W2772063040 @default.
• W2922130736 cites W2772888206 @default.
• W2922130736 cites W3006080604 @default.
• W2922130736 cites W3152044313 @default.
• W2922130736 cites W848515071 @default.
• W2922130736 doi "https://doi.org/10.3899/jrheum.180904" @default.
• W2922130736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30877216" @default.
• W2922130736 hasPublicationYear "2019" @default.
• W2922130736 type Work @default.
• W2922130736 sameAs 2922130736 @default.
• W2922130736 citedByCount "9" @default.
• W2922130736 countsByYear W29221307362019 @default.
• W2922130736 countsByYear W29221307362020 @default.
• W2922130736 countsByYear W29221307362022 @default.
• W2922130736 crossrefType "journal-article" @default.
• W2922130736 hasAuthorship W2922130736A5004560391 @default.
• W2922130736 hasAuthorship W2922130736A5009151561 @default.
• W2922130736 hasAuthorship W2922130736A5012283576 @default.
• W2922130736 hasAuthorship W2922130736A5016395117 @default.
• W2922130736 hasAuthorship W2922130736A5029781530 @default.
• W2922130736 hasAuthorship W2922130736A5033861263 @default.
• W2922130736 hasAuthorship W2922130736A5042476895 @default.
• W2922130736 hasAuthorship W2922130736A5069919512 @default.
• W2922130736 hasAuthorship W2922130736A5091895459 @default.
• W2922130736 hasBestOaLocation W29221307361 @default.
• W2922130736 hasConcept C111278954 @default.
• W2922130736 hasConcept C126322002 @default.
• W2922130736 hasConcept C141071460 @default.
• W2922130736 hasConcept C142724271 @default.
• W2922130736 hasConcept C168563851 @default.
• W2922130736 hasConcept C197934379 @default.
• W2922130736 hasConcept C203092338 @default.
• W2922130736 hasConcept C204787440 @default.
• W2922130736 hasConcept C27081682 @default.
• W2922130736 hasConcept C2777575956 @default.
• W2922130736 hasConcept C2910384678 @default.
• W2922130736 hasConcept C512399662 @default.
• W2922130736 hasConcept C71924100 @default.
• W2922130736 hasConceptScore W2922130736C111278954 @default.
• W2922130736 hasConceptScore W2922130736C126322002 @default.
• W2922130736 hasConceptScore W2922130736C141071460 @default.
• W2922130736 hasConceptScore W2922130736C142724271 @default.
• W2922130736 hasConceptScore W2922130736C168563851 @default.
• W2922130736 hasConceptScore W2922130736C197934379 @default.
• W2922130736 hasConceptScore W2922130736C203092338 @default.
• W2922130736 hasConceptScore W2922130736C204787440 @default.
• W2922130736 hasConceptScore W2922130736C27081682 @default.
• W2922130736 hasConceptScore W2922130736C2777575956 @default.
• W2922130736 hasConceptScore W2922130736C2910384678 @default.
• W2922130736 hasConceptScore W2922130736C512399662 @default.
• W2922130736 hasConceptScore W2922130736C71924100 @default.
• W2922130736 hasIssue "10" @default.
• W2922130736 hasLocation W29221307361 @default.
• W2922130736 hasLocation W29221307362 @default.

• next