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• W2922131522 startingPage "153" @default.
• W2922131522 abstract "Nowadays, proliferation of jellyfish has become a severe matter in many coastal areas around the world. Jellyfish Nemopilema nomurai is one of the most perilous organisms and leads to significant deleterious outcomes such as harm to the fishery, damage the coastal equipment, and moreover, its envenomation can be hazardous to the victims. Till now, the components of Nemopilema nomurai venom (NnV) are unknown owing to scant transcriptomics and genomic data. In the current research, we have explored a proteomic approach to identify NnV components and their interrelation with pathological effects caused by the jellyfish sting. Altogether, 150 proteins were identified, comprising toxins and other distinct proteins that are substantial in nematocyst genesis and nematocyte growth by employing two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI/TOF/MS). The identified toxins are phospholipase A2, phospholipase D Li Sic Tox beta IDI, a serine protease, putative Kunitz-type serine protease inhibitor, disintegrin and metalloproteinase, hemolysin, leukotoxin, three finger toxin MALT0044C, allergens, venom prothrombin activator trocarin D, tripeptide Gsp 9.1, and along with other toxin proteins. These toxins are relatively well characterized in the venoms of other poisonous species to induce pathogenesis, hemolysis, inflammation, proteolysis, blood coagulation, cytolysis, hemorrhagic activity, and type 1 hypersensitivity, suggesting that these toxins in NnV can also cause similar deleterious consequences. Our proteomic works indicate that NnV protein profile represents valuable source which leads to better understanding the clinical features of the jellyfish stings. As one of the largest jellyfish in the world, Nemopilema nomurai sting is considered to be harmful to humans due to its potent toxicity. The identification and functional characterization of its venom components have been poorly described and are beyond our knowledge. Here is the first report demonstrating the methodical overview of NnV proteomics research, providing significant information to understand the mechanism of NnV envenomation. Our proteomics findings can provide a platform for novel protein discovery and development of practical ways to deal with jellyfish stings on human beings." @default.
• W2922131522 created "2019-03-22" @default.
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• W2922131522 date "2019-03-08" @default.
• W2922131522 modified "2023-10-14" @default.
• W2922131522 title "Proteomic Analysis of Novel Components of Nemopilema nomurai Jellyfish Venom: Deciphering the Mode of Action" @default.
• W2922131522 cites W1791502820 @default.
• W2922131522 cites W1846211089 @default.
• W2922131522 cites W1924646174 @default.
• W2922131522 cites W1963685109 @default.
• W2922131522 cites W1965917470 @default.
• W2922131522 cites W1967703874 @default.
• W2922131522 cites W1968160465 @default.
• W2922131522 cites W1969932442 @default.
• W2922131522 cites W1973290265 @default.
• W2922131522 cites W1975101663 @default.
• W2922131522 cites W1975312872 @default.
• W2922131522 cites W1977544151 @default.
• W2922131522 cites W1980540895 @default.
• W2922131522 cites W1981977376 @default.
• W2922131522 cites W1989983958 @default.
• W2922131522 cites W1990146359 @default.
• W2922131522 cites W1993145559 @default.
• W2922131522 cites W1999511488 @default.
• W2922131522 cites W2005541825 @default.
• W2922131522 cites W2008573474 @default.
• W2922131522 cites W2017825213 @default.
• W2922131522 cites W2018890481 @default.
• W2922131522 cites W2020921331 @default.
• W2922131522 cites W2030174975 @default.
• W2922131522 cites W2032353683 @default.
• W2922131522 cites W2035074554 @default.
• W2922131522 cites W2038286480 @default.
• W2922131522 cites W2042906184 @default.
• W2922131522 cites W2043136561 @default.
• W2922131522 cites W2043610985 @default.
• W2922131522 cites W2043676276 @default.
• W2922131522 cites W2044387366 @default.
• W2922131522 cites W2047081204 @default.
• W2922131522 cites W2049946868 @default.
• W2922131522 cites W2050981119 @default.
• W2922131522 cites W2052668460 @default.
• W2922131522 cites W2053976302 @default.
• W2922131522 cites W2054636364 @default.
• W2922131522 cites W2056804261 @default.
• W2922131522 cites W2068220661 @default.
• W2922131522 cites W2076222762 @default.
• W2922131522 cites W2076363185 @default.
• W2922131522 cites W2080413976 @default.
• W2922131522 cites W2084738263 @default.
• W2922131522 cites W2085198342 @default.
• W2922131522 cites W2089400034 @default.
• W2922131522 cites W2093482892 @default.
• W2922131522 cites W2095018173 @default.
• W2922131522 cites W2100459517 @default.
• W2922131522 cites W2104940964 @default.
• W2922131522 cites W2109438607 @default.
• W2922131522 cites W2110193388 @default.
• W2922131522 cites W2117521691 @default.
• W2922131522 cites W2123994723 @default.
• W2922131522 cites W2125391882 @default.
• W2922131522 cites W2126024920 @default.
• W2922131522 cites W2128635872 @default.
• W2922131522 cites W2138162031 @default.
• W2922131522 cites W2143457814 @default.
• W2922131522 cites W2156800049 @default.
• W2922131522 cites W2160391547 @default.
• W2922131522 cites W2160416298 @default.
• W2922131522 cites W2162143249 @default.
• W2922131522 cites W2166974823 @default.
• W2922131522 cites W2169200863 @default.
• W2922131522 cites W2170405275 @default.
• W2922131522 cites W2171498520 @default.
• W2922131522 cites W2185046875 @default.
• W2922131522 cites W2214881996 @default.
• W2922131522 cites W2337705261 @default.
• W2922131522 cites W2496825240 @default.
• W2922131522 cites W2527520038 @default.
• W2922131522 cites W2528996839 @default.
• W2922131522 cites W4293247451 @default.
• W2922131522 cites W83005937 @default.
• W2922131522 cites W909954097 @default.
• W2922131522 cites W18695367 @default.
• W2922131522 doi "https://doi.org/10.3390/toxins11030153" @default.
• W2922131522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6468547" @default.
• W2922131522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30857234" @default.
• W2922131522 hasPublicationYear "2019" @default.
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