FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922135344> ?p ?o ?g. }

• W2922135344 endingPage "432" @default.
• W2922135344 startingPage "421" @default.
• W2922135344 abstract "Rho-kinase is an essential downstream target of GTP-binding protein RhoA, and plays a crucial role in the calcium-sensitization pathway. Rho-kinase pathway is critically involved in phosphorylation state of myosin light chain, leading to increased contraction of smooth muscles. Inhibition of this pathway has turned out to be a promising target for several indications such as cardiovascular diseases, glaucoma and inflammatory diseases.The present work focuses on a division-based 2D quantitative structure-activity relationship (QSAR) analysis along with a docking study to predict structural features that may be essential for the enhancement of selectivity and potency of the target compounds. Furthermore, a set of indoles and azaindoles were also projected based on the regression equation as novel developments. Molecular docking was applied for exploring the binding sites of the newly predicted set of compounds with the receptor.Results of the docked conformations suggested that introduction of non-bulky and substituted groups in the hinge region of ROCK-II ATP binding pocket would improve the activity by decreasing the bulkiness or length of the compounds.ADME studies were performed to ascertain the novelty and drug-like properties of the designed molecules, respectively." @default.
• W2922135344 created "2019-03-22" @default.
• W2922135344 creator A5049756208 @default.
• W2922135344 creator A5051970443 @default.
• W2922135344 creator A5060702151 @default.
• W2922135344 creator A5061735265 @default.
• W2922135344 creator A5063702691 @default.
• W2922135344 creator A5076395313 @default.
• W2922135344 creator A5078659661 @default.
• W2922135344 creator A5082281202 @default.
• W2922135344 date "2019-09-23" @default.
• W2922135344 modified "2023-10-03" @default.
• W2922135344 title "In-Silico QSAR Modelling of Predicted Rho Kinase Inhibitors Against Cardio Vascular Diseases" @default.
• W2922135344 cites W1570912112 @default.
• W2922135344 cites W1977814896 @default.
• W2922135344 cites W1978227827 @default.
• W2922135344 cites W2015931265 @default.
• W2922135344 cites W2020699622 @default.
• W2922135344 cites W2060027629 @default.
• W2922135344 cites W2074049820 @default.
• W2922135344 cites W2075340114 @default.
• W2922135344 cites W2086190989 @default.
• W2922135344 cites W2115838194 @default.
• W2922135344 cites W2130589134 @default.
• W2922135344 cites W2165670223 @default.
• W2922135344 cites W2233428981 @default.
• W2922135344 cites W2321405141 @default.
• W2922135344 cites W2772692178 @default.
• W2922135344 cites W2884017981 @default.
• W2922135344 doi "https://doi.org/10.2174/1573409915666190307163437" @default.
• W2922135344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30848208" @default.
• W2922135344 hasPublicationYear "2019" @default.
• W2922135344 type Work @default.
• W2922135344 sameAs 2922135344 @default.
• W2922135344 citedByCount "1" @default.
• W2922135344 countsByYear W29221353442022 @default.
• W2922135344 crossrefType "journal-article" @default.
• W2922135344 hasAuthorship W2922135344A5049756208 @default.
• W2922135344 hasAuthorship W2922135344A5051970443 @default.
• W2922135344 hasAuthorship W2922135344A5060702151 @default.
• W2922135344 hasAuthorship W2922135344A5061735265 @default.
• W2922135344 hasAuthorship W2922135344A5063702691 @default.
• W2922135344 hasAuthorship W2922135344A5076395313 @default.
• W2922135344 hasAuthorship W2922135344A5078659661 @default.
• W2922135344 hasAuthorship W2922135344A5082281202 @default.
• W2922135344 hasConcept C104317684 @default.
• W2922135344 hasConcept C11960822 @default.
• W2922135344 hasConcept C12554922 @default.
• W2922135344 hasConcept C133717845 @default.
• W2922135344 hasConcept C159110408 @default.
• W2922135344 hasConcept C164126121 @default.
• W2922135344 hasConcept C184235292 @default.
• W2922135344 hasConcept C185592680 @default.
• W2922135344 hasConcept C201800478 @default.
• W2922135344 hasConcept C202751555 @default.
• W2922135344 hasConcept C2775905019 @default.
• W2922135344 hasConcept C41685203 @default.
• W2922135344 hasConcept C55493867 @default.
• W2922135344 hasConcept C69366308 @default.
• W2922135344 hasConcept C70721500 @default.
• W2922135344 hasConcept C71240020 @default.
• W2922135344 hasConcept C71924100 @default.
• W2922135344 hasConcept C8035138 @default.
• W2922135344 hasConcept C86803240 @default.
• W2922135344 hasConcept C97029542 @default.
• W2922135344 hasConceptScore W2922135344C104317684 @default.
• W2922135344 hasConceptScore W2922135344C11960822 @default.
• W2922135344 hasConceptScore W2922135344C12554922 @default.
• W2922135344 hasConceptScore W2922135344C133717845 @default.
• W2922135344 hasConceptScore W2922135344C159110408 @default.
• W2922135344 hasConceptScore W2922135344C164126121 @default.
• W2922135344 hasConceptScore W2922135344C184235292 @default.
• W2922135344 hasConceptScore W2922135344C185592680 @default.
• W2922135344 hasConceptScore W2922135344C201800478 @default.
• W2922135344 hasConceptScore W2922135344C202751555 @default.
• W2922135344 hasConceptScore W2922135344C2775905019 @default.
• W2922135344 hasConceptScore W2922135344C41685203 @default.
• W2922135344 hasConceptScore W2922135344C55493867 @default.
• W2922135344 hasConceptScore W2922135344C69366308 @default.
• W2922135344 hasConceptScore W2922135344C70721500 @default.
• W2922135344 hasConceptScore W2922135344C71240020 @default.
• W2922135344 hasConceptScore W2922135344C71924100 @default.
• W2922135344 hasConceptScore W2922135344C8035138 @default.
• W2922135344 hasConceptScore W2922135344C86803240 @default.
• W2922135344 hasConceptScore W2922135344C97029542 @default.
• W2922135344 hasIssue "5" @default.
• W2922135344 hasLocation W29221353441 @default.
• W2922135344 hasLocation W29221353442 @default.
• W2922135344 hasOpenAccess W2922135344 @default.
• W2922135344 hasPrimaryLocation W29221353441 @default.
• W2922135344 hasRelatedWork W1574657119 @default.
• W2922135344 hasRelatedWork W2024788260 @default.
• W2922135344 hasRelatedWork W2041388184 @default.
• W2922135344 hasRelatedWork W2064956914 @default.
• W2922135344 hasRelatedWork W2896390069 @default.
• W2922135344 hasRelatedWork W2922135344 @default.
• W2922135344 hasRelatedWork W3013449331 @default.
• W2922135344 hasRelatedWork W3135706395 @default.

• next