Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922136325> ?p ?o ?g. }
- W2922136325 endingPage "108775" @default.
- W2922136325 startingPage "108775" @default.
- W2922136325 abstract "Autophagy, literally meaning self-eating, is a highly conserved process that is part of the eukaryotic cell cycle. Morphologically, the double membrane contains vesicles with phagocytic components known as autophagosomes. Autophagy is often used as a cellular stress response and quality control mechanisms are used to maintain cell survival. Survival is facilitated by providing energy and metabolic precursors as well as removing damaged proteins or organelles. Moreover, autophagy refers to organelles fused together with part of the cell cytoplasm with a double or multi-membrane structure called phagosome. Research has demonstrated that autophagy is an important mediator of cell fate and has effects on inflammation, pathogen clearance, and antigen presentation. In recent years, studies discussing autophagy have increased in number. Nevertheless, only a small amount of research has considered the impact of autophagy on the pathogenesis of skin diseases. The skin is the largest organ of the body, with a surface area of around two square metre; it is the first line of defense against numerous environmental insults, including ultraviolet radiation, pathogens, mechanical stresses, and toxic chemicals. Autophagy is thought to be a vital modality for endogenous defenses against environmental derangements. This review provides an overview of autophagy machinery in keratinocytes, skin fibroblasts, melanocytes related to skin diseases as well as strategies for therapeutic modulation, for the future development of treatment for skin diseases." @default.
- W2922136325 created "2019-03-22" @default.
- W2922136325 creator A5001578318 @default.
- W2922136325 creator A5022454880 @default.
- W2922136325 creator A5030348054 @default.
- W2922136325 creator A5041723924 @default.
- W2922136325 creator A5050939892 @default.
- W2922136325 creator A5082652766 @default.
- W2922136325 creator A5085073172 @default.
- W2922136325 date "2019-05-01" @default.
- W2922136325 modified "2023-10-16" @default.
- W2922136325 title "Insights into autophagy machinery in cells related to skin diseases and strategies for therapeutic modulation" @default.
- W2922136325 cites W1506877621 @default.
- W2922136325 cites W1506894149 @default.
- W2922136325 cites W1560389661 @default.
- W2922136325 cites W1844714889 @default.
- W2922136325 cites W1872474147 @default.
- W2922136325 cites W1918384196 @default.
- W2922136325 cites W1971782825 @default.
- W2922136325 cites W1972403339 @default.
- W2922136325 cites W1972763155 @default.
- W2922136325 cites W1974015025 @default.
- W2922136325 cites W1977338312 @default.
- W2922136325 cites W1981358316 @default.
- W2922136325 cites W1985124617 @default.
- W2922136325 cites W1988918021 @default.
- W2922136325 cites W1989821468 @default.
- W2922136325 cites W1990622149 @default.
- W2922136325 cites W1991105254 @default.
- W2922136325 cites W1997184663 @default.
- W2922136325 cites W1998462032 @default.
- W2922136325 cites W1999477136 @default.
- W2922136325 cites W1999882338 @default.
- W2922136325 cites W2001239820 @default.
- W2922136325 cites W2001675597 @default.
- W2922136325 cites W2002052058 @default.
- W2922136325 cites W2002562463 @default.
- W2922136325 cites W2007724190 @default.
- W2922136325 cites W2010913335 @default.
- W2922136325 cites W2016791486 @default.
- W2922136325 cites W2025665129 @default.
- W2922136325 cites W2028536701 @default.
- W2922136325 cites W2033374599 @default.
- W2922136325 cites W2039607936 @default.
- W2922136325 cites W2040157483 @default.
- W2922136325 cites W2042430874 @default.
- W2922136325 cites W2046250764 @default.
- W2922136325 cites W2049528479 @default.
- W2922136325 cites W2053950470 @default.
- W2922136325 cites W2054960752 @default.
- W2922136325 cites W2062466754 @default.
- W2922136325 cites W2065844510 @default.
- W2922136325 cites W2067211026 @default.
- W2922136325 cites W2067692987 @default.
- W2922136325 cites W2070500204 @default.
- W2922136325 cites W2072962611 @default.
- W2922136325 cites W2073717392 @default.
- W2922136325 cites W2074857405 @default.
- W2922136325 cites W2081964494 @default.
- W2922136325 cites W2097573947 @default.
- W2922136325 cites W2102776209 @default.
- W2922136325 cites W2104294732 @default.
- W2922136325 cites W2104413131 @default.
- W2922136325 cites W2109285107 @default.
- W2922136325 cites W2113432343 @default.
- W2922136325 cites W2113840211 @default.
- W2922136325 cites W2116367518 @default.
- W2922136325 cites W2119306391 @default.
- W2922136325 cites W2126933314 @default.
- W2922136325 cites W2129783904 @default.
- W2922136325 cites W2139354073 @default.
- W2922136325 cites W2143916596 @default.
- W2922136325 cites W2145609957 @default.
- W2922136325 cites W2148281700 @default.
- W2922136325 cites W2155175976 @default.
- W2922136325 cites W2155992491 @default.
- W2922136325 cites W2161632339 @default.
- W2922136325 cites W2165722578 @default.
- W2922136325 cites W2167810415 @default.
- W2922136325 cites W2259840879 @default.
- W2922136325 cites W2262412442 @default.
- W2922136325 cites W2295124356 @default.
- W2922136325 cites W2323322844 @default.
- W2922136325 cites W2346638830 @default.
- W2922136325 cites W2351352652 @default.
- W2922136325 cites W2386447396 @default.
- W2922136325 cites W2399993055 @default.
- W2922136325 cites W2415075823 @default.
- W2922136325 cites W2461465860 @default.
- W2922136325 cites W2465156857 @default.
- W2922136325 cites W2510304453 @default.
- W2922136325 cites W2514395211 @default.
- W2922136325 cites W2530158439 @default.
- W2922136325 cites W2570013761 @default.
- W2922136325 cites W2583893291 @default.
- W2922136325 cites W2586101188 @default.
- W2922136325 cites W2596176257 @default.
- W2922136325 cites W2604223744 @default.