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• W2922136998 abstract "Abstract Mutations of Fused in sarcoma (FUS), a ribonucleoprotein involved in RNA metabolism, have been found associated with both familial and sporadic cases of amyotrophic lateral sclerosis (ALS). Notably, besides mutations in the coding sequence, also mutations into the 3′ untranslated region, leading to increased levels of the wild-type protein, have been associated with neuronal death and ALS pathology, in ALS models and patients. The mechanistic link between altered FUS levels and ALS-related neurodegeneration is far to be elucidated, as well as the consequences of elevated FUS levels in the modulation of the inflammatory response sustained by glial cells, a well-recognized player in ALS progression. Here, we studied the effect of wild-type FUS overexpression on the responsiveness of mouse and human neural progenitor-derived astrocytes to a pro-inflammatory stimulus (IL1β) used to mimic an inflammatory environment. We found that astrocytes with increased FUS levels were more sensitive to IL1β, as shown by their enhanced expression of inflammatory genes, compared with control astrocytes. Moreover, astrocytes overexpressing FUS promoted neuronal cell death and pro-inflammatory microglia activation. We conclude that overexpression of wild-type FUS intrinsically affects astrocyte reactivity and drives their properties toward pro-inflammatory and neurotoxic functions, suggesting that a non-cell autonomous mechanism can support neurodegeneration in FUS-mutated animals and patients." @default.
• W2922136998 created "2019-03-22" @default.
• W2922136998 creator A5000947992 @default.
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• W2922136998 date "2019-03-14" @default.
• W2922136998 modified "2023-09-30" @default.
• W2922136998 title "Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death" @default.
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• W2922136998 cites W1966097798 @default.
• W2922136998 cites W1970433280 @default.
• W2922136998 cites W1971516308 @default.
• W2922136998 cites W1975096886 @default.
• W2922136998 cites W1976689131 @default.
• W2922136998 cites W1986285940 @default.
• W2922136998 cites W1989365868 @default.
• W2922136998 cites W1990078383 @default.
• W2922136998 cites W2006228903 @default.
• W2922136998 cites W2007222211 @default.
• W2922136998 cites W2012662246 @default.
• W2922136998 cites W2019129236 @default.
• W2922136998 cites W2023374767 @default.
• W2922136998 cites W2023769419 @default.
• W2922136998 cites W2024381085 @default.
• W2922136998 cites W2029466481 @default.
• W2922136998 cites W2042311402 @default.
• W2922136998 cites W2048813950 @default.
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• W2922136998 cites W2065894198 @default.
• W2922136998 cites W2066090522 @default.
• W2922136998 cites W2066828509 @default.
• W2922136998 cites W2068147651 @default.
• W2922136998 cites W2069560534 @default.
• W2922136998 cites W2073190029 @default.
• W2922136998 cites W2074555134 @default.
• W2922136998 cites W2074726646 @default.
• W2922136998 cites W2075887783 @default.
• W2922136998 cites W2076410921 @default.
• W2922136998 cites W2087079891 @default.
• W2922136998 cites W2087394619 @default.
• W2922136998 cites W2090836465 @default.
• W2922136998 cites W2091101857 @default.
• W2922136998 cites W2101321540 @default.
• W2922136998 cites W2103246829 @default.
• W2922136998 cites W2103901522 @default.
• W2922136998 cites W2105348268 @default.
• W2922136998 cites W2106150419 @default.
• W2922136998 cites W2108191354 @default.
• W2922136998 cites W2112507261 @default.
• W2922136998 cites W2112538318 @default.
• W2922136998 cites W2113249378 @default.
• W2922136998 cites W2115637560 @default.
• W2922136998 cites W2135607950 @default.
• W2922136998 cites W2137007484 @default.
• W2922136998 cites W2139253645 @default.
• W2922136998 cites W2139778190 @default.
• W2922136998 cites W2144507462 @default.
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• W2922136998 cites W2198605922 @default.
• W2922136998 cites W2218838944 @default.
• W2922136998 cites W2281819947 @default.
• W2922136998 cites W2296358664 @default.
• W2922136998 cites W2296809607 @default.
• W2922136998 cites W2338530425 @default.
• W2922136998 cites W2506892399 @default.
• W2922136998 cites W2531304605 @default.
• W2922136998 cites W2572710398 @default.
• W2922136998 cites W2588669396 @default.
• W2922136998 cites W2598241518 @default.
• W2922136998 cites W2602367484 @default.
• W2922136998 cites W2604429195 @default.
• W2922136998 cites W2604634031 @default.
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• W2922136998 cites W2761493700 @default.
• W2922136998 cites W2791141811 @default.
• W2922136998 cites W2802669613 @default.
• W2922136998 cites W2807519757 @default.
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• W2922136998 doi "https://doi.org/10.1038/s41598-019-41040-4" @default.
• W2922136998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6418113" @default.
• W2922136998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30872738" @default.
• W2922136998 hasPublicationYear "2019" @default.
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