FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922143496> ?p ?o ?g. }

• W2922143496 endingPage "37" @default.
• W2922143496 startingPage "27" @default.
• W2922143496 abstract "Small Ras GTPases are key molecules that regulate a variety of cellular responses in different cell types. Rap1 plays important functions in the regulation of macrophage biology during inflammation triggered by toll-like receptors (TLRs). However, despite sharing a relatively high degree of similarity with Rap1, no studies concerning Rap2 in macrophages and innate immunity have been reported yet. In this work, we show that either way alterations in the levels of Rap2a hampers proper macrophages response to TLR stimulation. Rap2a is activated by LPS in macrophages, and although putative activator TLR-inducible Ras guanine exchange factor RasGEF1b was sufficient to induce, it was not fully required for Rap2a activation. Silencing of Rap2a impaired LPS-induced production of IL-6 cytokine and KC/Cxcl1 chemokine, and also NF-κB activity as measured by reporter gene studies. Surprisingly, overexpression of Rap2a did also lead to marked inhibition of NF-κB activation induced by LPS, Pam3CSK4 and downstream TLR signaling molecules. We also found that Rap2a can inhibit the LPS-induced phosphorylation of the NF-κB subunit p65 at serine 536. Collectively, our data suggest that expression levels of Rap2a in macrophages might be tightly regulated to avoid unbalanced immune response. Our results implicate Rap2a in TLR-mediated responses by contributing to balanced NF-κB activity status in macrophages." @default.
• W2922143496 created "2019-03-22" @default.
• W2922143496 creator A5006596072 @default.
• W2922143496 creator A5010560401 @default.
• W2922143496 creator A5015618896 @default.
• W2922143496 creator A5035128241 @default.
• W2922143496 creator A5044844412 @default.
• W2922143496 creator A5054251053 @default.
• W2922143496 creator A5058932757 @default.
• W2922143496 creator A5059401978 @default.
• W2922143496 creator A5065957840 @default.
• W2922143496 creator A5081499202 @default.
• W2922143496 date "2019-05-01" @default.
• W2922143496 modified "2023-09-27" @default.
• W2922143496 title "Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-κB activity and inflammatory gene expression" @default.
• W2922143496 cites W1538985229 @default.
• W2922143496 cites W1564772833 @default.
• W2922143496 cites W1608013458 @default.
• W2922143496 cites W1669198605 @default.
• W2922143496 cites W1964451796 @default.
• W2922143496 cites W1969052506 @default.
• W2922143496 cites W1975275391 @default.
• W2922143496 cites W1979116048 @default.
• W2922143496 cites W1979991119 @default.
• W2922143496 cites W1982792491 @default.
• W2922143496 cites W1987067331 @default.
• W2922143496 cites W1995104195 @default.
• W2922143496 cites W1996063901 @default.
• W2922143496 cites W1996441660 @default.
• W2922143496 cites W1999732094 @default.
• W2922143496 cites W2002953250 @default.
• W2922143496 cites W2003229639 @default.
• W2922143496 cites W2010919030 @default.
• W2922143496 cites W2021662182 @default.
• W2922143496 cites W2026350709 @default.
• W2922143496 cites W2033023829 @default.
• W2922143496 cites W2039629780 @default.
• W2922143496 cites W2042209974 @default.
• W2922143496 cites W2057802686 @default.
• W2922143496 cites W2063193026 @default.
• W2922143496 cites W2075900101 @default.
• W2922143496 cites W2084629225 @default.
• W2922143496 cites W2095187370 @default.
• W2922143496 cites W2098594962 @default.
• W2922143496 cites W2109319033 @default.
• W2922143496 cites W2126332225 @default.
• W2922143496 cites W2127888962 @default.
• W2922143496 cites W2141320958 @default.
• W2922143496 cites W2143086493 @default.
• W2922143496 cites W2143507642 @default.
• W2922143496 cites W2145065899 @default.
• W2922143496 cites W2147939322 @default.
• W2922143496 cites W2148112019 @default.
• W2922143496 cites W2148658155 @default.
• W2922143496 cites W2173344695 @default.
• W2922143496 cites W2273176468 @default.
• W2922143496 cites W2340768044 @default.
• W2922143496 cites W2500457520 @default.
• W2922143496 cites W2592727452 @default.
• W2922143496 cites W2606063798 @default.
• W2922143496 cites W2620173316 @default.
• W2922143496 cites W2732767128 @default.
• W2922143496 cites W2766339762 @default.
• W2922143496 cites W2808743966 @default.
• W2922143496 cites W2888628838 @default.
• W2922143496 cites W2943337737 @default.
• W2922143496 cites W41879369 @default.
• W2922143496 doi "https://doi.org/10.1016/j.molimm.2019.02.015" @default.
• W2922143496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30851634" @default.
• W2922143496 hasPublicationYear "2019" @default.
• W2922143496 type Work @default.
• W2922143496 sameAs 2922143496 @default.
• W2922143496 citedByCount "7" @default.
• W2922143496 countsByYear W29221434962019 @default.
• W2922143496 countsByYear W29221434962020 @default.
• W2922143496 countsByYear W29221434962021 @default.
• W2922143496 countsByYear W29221434962022 @default.
• W2922143496 crossrefType "journal-article" @default.
• W2922143496 hasAuthorship W2922143496A5006596072 @default.
• W2922143496 hasAuthorship W2922143496A5010560401 @default.
• W2922143496 hasAuthorship W2922143496A5015618896 @default.
• W2922143496 hasAuthorship W2922143496A5035128241 @default.
• W2922143496 hasAuthorship W2922143496A5044844412 @default.
• W2922143496 hasAuthorship W2922143496A5054251053 @default.
• W2922143496 hasAuthorship W2922143496A5058932757 @default.
• W2922143496 hasAuthorship W2922143496A5059401978 @default.
• W2922143496 hasAuthorship W2922143496A5065957840 @default.
• W2922143496 hasAuthorship W2922143496A5081499202 @default.
• W2922143496 hasConcept C126619667 @default.
• W2922143496 hasConcept C13373296 @default.
• W2922143496 hasConcept C136449434 @default.
• W2922143496 hasConcept C170493617 @default.
• W2922143496 hasConcept C203014093 @default.
• W2922143496 hasConcept C207332259 @default.
• W2922143496 hasConcept C2776179587 @default.
• W2922143496 hasConcept C2776914184 @default.
• W2922143496 hasConcept C2777730290 @default.
• W2922143496 hasConcept C2778690821 @default.

• next