FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922143627> ?p ?o ?g. }

• W2922143627 endingPage "1670" @default.
• W2922143627 startingPage "1654" @default.
• W2922143627 abstract "In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited and tumor growth delayed following postnatal deletion of Tgfbr2 in the endothelium of Cdh5-CreERT2 Tgfbr2fl/fl mice (Tgfbr2iECKO mice). ECs from Tgfbr2iECKO mice failed to upregulate the fibrinolysis inhibitor plasminogen activator inhibitor 1 (Serpine1, also known as PAI-1), due in part to uncoupled TGF-β-mediated suppression of miR-30c. Bypassing TGF-β signaling with vascular tropic nanoparticles that deliver miR-30c antagomiRs promoted PAI-1-dependent tumor growth and increased fibrin abundance, whereas miR-30c mimics inhibited tumor growth and promoted vascular-directed fibrinolysis in vivo. Using single-cell RNA-Seq and a NanoString miRNA array, we also found that subtypes of ECs in tumors showed spectrums of Serpine1 and miR-30c expression levels, suggesting functional diversity in ECs at the level of individual cells; indeed, fresh EC isolates from lung and mammary tumor models had differential abilities to degrade fibrin and launch new vessel sprouts, a finding that was linked to their inverse expression patterns of miR-30c and Serpine1 (i.e., miR-30chi Serpine1lo ECs were poorly angiogenic and miR-30clo Serpine1hi ECs were highly angiogenic). Thus, by balancing Serpine1 expression in ECs downstream of TGF-β, miR-30c functions as a tumor suppressor in the tumor microenvironment through its ability to promote fibrin degradation and inhibit blood vessel formation." @default.
• W2922143627 created "2019-03-22" @default.
• W2922143627 creator A5006543954 @default.
• W2922143627 creator A5007566392 @default.
• W2922143627 creator A5017773172 @default.
• W2922143627 creator A5036096394 @default.
• W2922143627 creator A5054811851 @default.
• W2922143627 creator A5055227358 @default.
• W2922143627 creator A5062791427 @default.
• W2922143627 creator A5063733765 @default.
• W2922143627 creator A5065937818 @default.
• W2922143627 creator A5068228499 @default.
• W2922143627 creator A5071843228 @default.
• W2922143627 creator A5075629445 @default.
• W2922143627 creator A5084586982 @default.
• W2922143627 creator A5086214120 @default.
• W2922143627 creator A5086704505 @default.
• W2922143627 date "2019-03-11" @default.
• W2922143627 modified "2023-10-12" @default.
• W2922143627 title "Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1" @default.
• W2922143627 cites W1036791879 @default.
• W2922143627 cites W1202879735 @default.
• W2922143627 cites W1234767369 @default.
• W2922143627 cites W1617233045 @default.
• W2922143627 cites W1636022999 @default.
• W2922143627 cites W1788687563 @default.
• W2922143627 cites W1822598714 @default.
• W2922143627 cites W1908896613 @default.
• W2922143627 cites W1963562384 @default.
• W2922143627 cites W1965038309 @default.
• W2922143627 cites W1967164403 @default.
• W2922143627 cites W1970098795 @default.
• W2922143627 cites W1976221474 @default.
• W2922143627 cites W1976729214 @default.
• W2922143627 cites W1978469147 @default.
• W2922143627 cites W2002050544 @default.
• W2922143627 cites W2002408287 @default.
• W2922143627 cites W2004280628 @default.
• W2922143627 cites W2005055996 @default.
• W2922143627 cites W2008119533 @default.
• W2922143627 cites W2012247886 @default.
• W2922143627 cites W2012483332 @default.
• W2922143627 cites W2013336992 @default.
• W2922143627 cites W2017358009 @default.
• W2922143627 cites W2023906705 @default.
• W2922143627 cites W2026325139 @default.
• W2922143627 cites W2028514452 @default.
• W2922143627 cites W2031300004 @default.
• W2922143627 cites W2036090950 @default.
• W2922143627 cites W2037046279 @default.
• W2922143627 cites W2037207845 @default.
• W2922143627 cites W2038933702 @default.
• W2922143627 cites W2039787319 @default.
• W2922143627 cites W2051282218 @default.
• W2922143627 cites W2056116866 @default.
• W2922143627 cites W2058689904 @default.
• W2922143627 cites W2062824992 @default.
• W2922143627 cites W2076136347 @default.
• W2922143627 cites W2088797440 @default.
• W2922143627 cites W2089318055 @default.
• W2922143627 cites W2090410012 @default.
• W2922143627 cites W2092565468 @default.
• W2922143627 cites W2097786065 @default.
• W2922143627 cites W2099045184 @default.
• W2922143627 cites W2102297721 @default.
• W2922143627 cites W2106641840 @default.
• W2922143627 cites W2111792559 @default.
• W2922143627 cites W2112455601 @default.
• W2922143627 cites W2114125544 @default.
• W2922143627 cites W2119999444 @default.
• W2922143627 cites W2130410032 @default.
• W2922143627 cites W2133243467 @default.
• W2922143627 cites W2133535765 @default.
• W2922143627 cites W2140997990 @default.
• W2922143627 cites W2143145016 @default.
• W2922143627 cites W2143895919 @default.
• W2922143627 cites W2146157095 @default.
• W2922143627 cites W2149932164 @default.
• W2922143627 cites W2150776809 @default.
• W2922143627 cites W2154453972 @default.
• W2922143627 cites W2154568166 @default.
• W2922143627 cites W2155542819 @default.
• W2922143627 cites W2160237679 @default.
• W2922143627 cites W2160732834 @default.
• W2922143627 cites W2162789670 @default.
• W2922143627 cites W2164615751 @default.
• W2922143627 cites W2164745800 @default.
• W2922143627 cites W2167346950 @default.
• W2922143627 cites W2214074259 @default.
• W2922143627 cites W2314203153 @default.
• W2922143627 cites W2338976782 @default.
• W2922143627 cites W2556941166 @default.
• W2922143627 cites W2565401689 @default.
• W2922143627 cites W2762420948 @default.
• W2922143627 cites W2792647356 @default.
• W2922143627 cites W2886119735 @default.
• W2922143627 cites W3099862724 @default.
• W2922143627 cites W32590006 @default.

• next