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- W2922146985 abstract "To determine if commensal oral microflora impacts the severity of chemotherapy-induced oral mucositis (OM). Specific-pathogen-free (SPF) and germ-free Swiss Webster mice in the experimental groups were dosed with 5-fluorouracil (5-FU) to induce OM. Mice in the control group received phosphate buffered saline. Comparative analyses of the epithelial thickness and cell proliferation/turnover rates, as well as the expression levels of metalloproteinases and pro-inflammatory mediators in the oral mucosa between the control and experimental groups were determined by histopathological and immunohistochemical analyses. 5-FU-treated SPF and germ-free mice showed characteristic features of OM with reduced oral epithelial thickness, presence of inflammatory cells in the connective tissues, and increased levels of expression of metalloproteinases and pro-inflammatory cytokines compared to the respective control groups. When 5-FU-treated SPF and germ-free mice were compared, 5-FU-treated germ-free mice exhibited less severe epithelial destruction with higher expression of the cell proliferation marker Ki67, coupled with lower expression levels of metalloproteinases and pro-inflammatory cytokine in the oral mucosa. This study provides the first histopathological evidence that oral flora has a detrimental effect on chemotherapy-induced OM in vivo." @default.
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- W2922146985 date "2019-05-01" @default.
- W2922146985 modified "2023-09-26" @default.
- W2922146985 title "Role of oral flora in chemotherapy-induced oral mucositis in vivo" @default.
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- W2922146985 doi "https://doi.org/10.1016/j.archoralbio.2019.03.008" @default.
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