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• W2922147630 abstract "Background Glomerular endothelial dysfunction and neoangiogenesis have long been implicated in the pathogenesis of diabetic kidney disease (DKD). However, the specific molecular pathways contributing to these processes in the early stages of DKD are not well understood. Our recent transcriptomic profiling of glomerular endothelial cells identified a number of proangiogenic genes that were upregulated in diabetic mice, including leucine-rich α -2-glycoprotein 1 (LRG1). LRG1 was previously shown to promote neovascularization in mouse models of ocular disease by potentiating endothelial TGF- β /activin receptor-like kinase 1 (ALK1) signaling. However, LRG1’s role in the kidney, particularly in the setting of DKD, has been unclear. Methods We analyzed expression of LRG1 mRNA in glomeruli of diabetic kidneys and assessed its localization by RNA in situ hybridization. We examined the effects of genetic ablation of Lrg1 on DKD progression in unilaterally nephrectomized, streptozotocin-induced diabetic mice at 12 and 20 weeks after diabetes induction. We also assessed whether plasma LRG1 was associated with renal outcome in patients with type 2 diabetes. Results LRG1 localized predominantly to glomerular endothelial cells, and its expression was elevated in the diabetic kidneys. LRG1 ablation markedly attenuated diabetes-induced glomerular angiogenesis, podocyte loss, and the development of diabetic glomerulopathy. These improvements were associated with reduced ALK1-Smad1/5/8 activation in glomeruli of diabetic mice. Moreover, increased plasma LRG1 was associated with worse renal outcome in patients with type 2 diabetes. Conclusions These findings identify LRG1 as a potential novel pathogenic mediator of diabetic glomerular neoangiogenesis and a risk factor in DKD progression." @default.
• W2922147630 created "2019-03-22" @default.
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• W2922147630 date "2019-03-11" @default.
• W2922147630 modified "2023-10-11" @default.
• W2922147630 title "LRG1 Promotes Diabetic Kidney Disease Progression by Enhancing TGF-<i>β</i>–Induced Angiogenesis" @default.
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• W2922147630 cites W1960895270 @default.
• W2922147630 cites W1968105116 @default.
• W2922147630 cites W1971119095 @default.
• W2922147630 cites W1971446487 @default.
• W2922147630 cites W1975246259 @default.
• W2922147630 cites W1976323462 @default.
• W2922147630 cites W1985604220 @default.
• W2922147630 cites W1986774614 @default.
• W2922147630 cites W2000021550 @default.
• W2922147630 cites W2001707140 @default.
• W2922147630 cites W2001867702 @default.
• W2922147630 cites W2002606648 @default.
• W2922147630 cites W2013459541 @default.
• W2922147630 cites W2022916583 @default.
• W2922147630 cites W2025991566 @default.
• W2922147630 cites W2030456072 @default.
• W2922147630 cites W2044773944 @default.
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• W2922147630 cites W2081322366 @default.
• W2922147630 cites W2089713276 @default.
• W2922147630 cites W2093629921 @default.
• W2922147630 cites W2098703367 @default.
• W2922147630 cites W2100976582 @default.
• W2922147630 cites W2108192985 @default.
• W2922147630 cites W2112231282 @default.
• W2922147630 cites W2112948259 @default.
• W2922147630 cites W2113328730 @default.
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• W2922147630 cites W2131193868 @default.
• W2922147630 cites W2131349854 @default.
• W2922147630 cites W2131400752 @default.
• W2922147630 cites W2132803823 @default.
• W2922147630 cites W2133182110 @default.
• W2922147630 cites W2138862624 @default.
• W2922147630 cites W2139947959 @default.
• W2922147630 cites W2146179253 @default.
• W2922147630 cites W2149027195 @default.
• W2922147630 cites W2152915643 @default.
• W2922147630 cites W2153816764 @default.
• W2922147630 cites W2153861174 @default.
• W2922147630 cites W2154556565 @default.
• W2922147630 cites W2155965977 @default.
• W2922147630 cites W2162368776 @default.
• W2922147630 cites W2163504684 @default.
• W2922147630 cites W2167627407 @default.
• W2922147630 cites W2231590221 @default.
• W2922147630 cites W2238778078 @default.
• W2922147630 cites W2289487108 @default.
• W2922147630 cites W2298682568 @default.
• W2922147630 cites W2298684454 @default.
• W2922147630 cites W2345941387 @default.
• W2922147630 cites W2405183840 @default.
• W2922147630 cites W2427873873 @default.
• W2922147630 cites W2475261460 @default.
• W2922147630 cites W2485218477 @default.
• W2922147630 cites W2521123529 @default.
• W2922147630 cites W2598087636 @default.
• W2922147630 cites W2603980776 @default.
• W2922147630 cites W2607031541 @default.
• W2922147630 cites W2615684303 @default.
• W2922147630 cites W2727072968 @default.
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• W2922147630 doi "https://doi.org/10.1681/asn.2018060599" @default.
• W2922147630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6442349" @default.
• W2922147630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30858225" @default.
• W2922147630 hasPublicationYear "2019" @default.
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