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• W2922148768 endingPage "1019" @default.
• W2922148768 startingPage "1005" @default.
• W2922148768 abstract "Lipid metabolism requires CoA, an essential cofactor found in multiple subcellular compartments, including the peroxisomes. In the liver, CoA levels are dynamically adjusted between the fed and fasted states. Elevated CoA levels in the fasted state are driven by increased synthesis; however, this also correlates with decreased expression of Nudix hydrolase (Nudt)7, the major CoA-degrading enzyme in the liver. Nudt7 resides in the peroxisomes, and we overexpressed this enzyme in mouse livers to determine its effect on the size and composition of the hepatic CoA pool in the fed and fasted states. Nudt7 overexpression did not change total CoA levels, but decreased the concentration of short-chain acyl-CoAs and choloyl-CoA in fasted livers, when endogenous Nudt7 activity was lowest. The effect on these acyl-CoAs correlated with a significant decrease in the hepatic bile acid content and in the rate of peroxisomal fatty acid oxidation, as estimated by targeted and untargeted metabolomics, combined with the measurement of fatty acid oxidation in intact hepatocytes. Identification of the CoA species and metabolic pathways affected by the overexpression on Nudt7 in vivo supports the conclusion that the nutritionally driven modulation of Nudt7 activity could contribute to the regulation of the peroxisomal CoA pool and peroxisomal lipid metabolism." @default.
• W2922148768 created "2019-03-22" @default.
• W2922148768 creator A5021266993 @default.
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• W2922148768 creator A5079786562 @default.
• W2922148768 creator A5089352283 @default.
• W2922148768 creator A5053185683 @default.
• W2922148768 date "2019-05-01" @default.
• W2922148768 modified "2023-10-11" @default.
• W2922148768 title "Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver" @default.
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• W2922148768 doi "https://doi.org/10.1194/jlr.m092676" @default.
• W2922148768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6495166" @default.
• W2922148768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33487369" @default.

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