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• W2922149895 abstract "Aim This subgroup analysis of a 12‐week randomized, double‐blind, and two‐center trial aimed to evaluate whether two different toothpaste formulations can differentially modulate the dental microbiome. Material and Methods Forty one mild to moderate periodontitis patients used as an adjunct to periodontal treatment either a toothpaste with anti‐adhesive zinc‐substituted carbonated hydroxyapatite ( HA ) or with antimicrobial and anti‐adhesive amine fluoride/stannous fluoride (AmF/SnF 2 ) during a 12‐week period. Plaque samples from buccal/lingual, interproximal, and subgingival sites were taken at baseline, 4 weeks after oral hygiene phase, and 8 weeks after periodontal therapy. Samples were analyzed with paired‐end Illumina Miseq 16S rDNA sequencing. The differences and changes on community level (alpha and beta diversity) and on the level of single agglomerated ribosomal sequence variants ( aRSV ) were calculated with analysis of covariance ( ANCOVA ) and likelihood ratio test ( LRT ). Results Interproximal and subgingival sites harbored predominately Fusobacterium and Prevotella species associated with periodontitis, whereas buccal/lingual sites harbored mainly Streptococcus and Veillonella species associated with periodontal health. Alpha and beta diversity did not change noticeably differently between both toothpaste groups ( P > 0.05, ANCOVA ). Furthermore, none of the aRSV s showed a noticeably different change between the tested toothpastes during periodontal therapy ( P adj . > 0.05, LRT ). Conclusion The use of a toothpaste containing anti‐adhesive HA did not induce statistically noticeably different changes on microbial composition compared to an antimicrobial and anti‐adhesive AmF/SnF 2 formulation." @default.
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• W2922149895 date "2019-03-09" @default.
• W2922149895 modified "2023-09-23" @default.
• W2922149895 title "No differences in microbiome changes between anti‐adhesive and antibacterial ingredients in toothpastes during periodontal therapy" @default.
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• W2922149895 doi "https://doi.org/10.1111/jre.12645" @default.
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