Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922151486> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2922151486 endingPage "296" @default.
- W2922151486 startingPage "290" @default.
- W2922151486 abstract "Abstract Platelet microparticles are the most frequent bloodstream microparticles (∼70–90%) which act as a vector for delivery of mRNA, miRNA and signaling proteins under physiological conditions. A variety of platelet microparticles were produced during the storage of platelet concentrates. In this study, platelet microparticles were isolated from platelet concentrates at day 3 of storage and used to deliver anti-HIV drugs including Lamivudine and Tenofovir. At first, encapsulation efficiency and release of anti-HIV drugs were evaluated by spectrophotometry at different wavelengths. Then, cellular uptake, cytotoxicity and HIV-1 inhibitory effects of drugs and drugs-platelet microparticles were assessed using flow cytometry, MTT and P24 assay kit in vitro. Our data showed that the platelet microparticles (300–1000 nm) have high ability for entrapment of Lamivudine and Tenofovir drugs up to 60% and 40%, respectively. Moreover, the release of drugs from the microparticles slowly occurred. HIV-1 inhibitory effects of Lamivudine- and Tenofovir-platelet microparticles were increased in comparison with drugs alone at different concentrations. Also, the toxicity of drugs loaded in the microparticles was decreased at various doses due to their slow release compared to drugs. Generally, platelet microparticles could be considered as a safe, inexpensive and natural vehicle for anti-HIV drug delivery compared to other synthetic nanoparticles." @default.
- W2922151486 created "2019-03-22" @default.
- W2922151486 creator A5013851784 @default.
- W2922151486 creator A5021107784 @default.
- W2922151486 creator A5080550711 @default.
- W2922151486 creator A5087970140 @default.
- W2922151486 date "2019-06-01" @default.
- W2922151486 modified "2023-09-30" @default.
- W2922151486 title "Platelet microparticles: An effective delivery system for anti-viral drugs" @default.
- W2922151486 cites W1787140000 @default.
- W2922151486 cites W1833080940 @default.
- W2922151486 cites W1901251024 @default.
- W2922151486 cites W1965781173 @default.
- W2922151486 cites W1972070926 @default.
- W2922151486 cites W1982605996 @default.
- W2922151486 cites W1983669079 @default.
- W2922151486 cites W1986328483 @default.
- W2922151486 cites W1996346598 @default.
- W2922151486 cites W2012650904 @default.
- W2922151486 cites W2036161137 @default.
- W2922151486 cites W2048018195 @default.
- W2922151486 cites W2130739913 @default.
- W2922151486 cites W2132939043 @default.
- W2922151486 cites W2151079805 @default.
- W2922151486 cites W2166846320 @default.
- W2922151486 cites W2168083885 @default.
- W2922151486 cites W2176918495 @default.
- W2922151486 cites W2187135215 @default.
- W2922151486 cites W2281134225 @default.
- W2922151486 cites W2588307382 @default.
- W2922151486 cites W2793139421 @default.
- W2922151486 cites W2794311085 @default.
- W2922151486 cites W2894179374 @default.
- W2922151486 cites W947799404 @default.
- W2922151486 doi "https://doi.org/10.1016/j.jddst.2019.03.009" @default.
- W2922151486 hasPublicationYear "2019" @default.
- W2922151486 type Work @default.
- W2922151486 sameAs 2922151486 @default.
- W2922151486 citedByCount "12" @default.
- W2922151486 countsByYear W29221514862021 @default.
- W2922151486 countsByYear W29221514862022 @default.
- W2922151486 countsByYear W29221514862023 @default.
- W2922151486 crossrefType "journal-article" @default.
- W2922151486 hasAuthorship W2922151486A5013851784 @default.
- W2922151486 hasAuthorship W2922151486A5021107784 @default.
- W2922151486 hasAuthorship W2922151486A5080550711 @default.
- W2922151486 hasAuthorship W2922151486A5087970140 @default.
- W2922151486 hasConcept C127413603 @default.
- W2922151486 hasConcept C159047783 @default.
- W2922151486 hasConcept C171250308 @default.
- W2922151486 hasConcept C192562407 @default.
- W2922151486 hasConcept C203014093 @default.
- W2922151486 hasConcept C2777521759 @default.
- W2922151486 hasConcept C2779820397 @default.
- W2922151486 hasConcept C2983812674 @default.
- W2922151486 hasConcept C42360764 @default.
- W2922151486 hasConcept C71924100 @default.
- W2922151486 hasConcept C89560881 @default.
- W2922151486 hasConcept C98274493 @default.
- W2922151486 hasConceptScore W2922151486C127413603 @default.
- W2922151486 hasConceptScore W2922151486C159047783 @default.
- W2922151486 hasConceptScore W2922151486C171250308 @default.
- W2922151486 hasConceptScore W2922151486C192562407 @default.
- W2922151486 hasConceptScore W2922151486C203014093 @default.
- W2922151486 hasConceptScore W2922151486C2777521759 @default.
- W2922151486 hasConceptScore W2922151486C2779820397 @default.
- W2922151486 hasConceptScore W2922151486C2983812674 @default.
- W2922151486 hasConceptScore W2922151486C42360764 @default.
- W2922151486 hasConceptScore W2922151486C71924100 @default.
- W2922151486 hasConceptScore W2922151486C89560881 @default.
- W2922151486 hasConceptScore W2922151486C98274493 @default.
- W2922151486 hasLocation W29221514861 @default.
- W2922151486 hasOpenAccess W2922151486 @default.
- W2922151486 hasPrimaryLocation W29221514861 @default.
- W2922151486 hasRelatedWork W2133717410 @default.
- W2922151486 hasRelatedWork W2435121771 @default.
- W2922151486 hasRelatedWork W2899084033 @default.
- W2922151486 hasRelatedWork W2901216924 @default.
- W2922151486 hasRelatedWork W2951469878 @default.
- W2922151486 hasRelatedWork W2994798565 @default.
- W2922151486 hasRelatedWork W3199018480 @default.
- W2922151486 hasRelatedWork W3209025911 @default.
- W2922151486 hasRelatedWork W4385310923 @default.
- W2922151486 hasRelatedWork W2782406604 @default.
- W2922151486 hasVolume "51" @default.
- W2922151486 isParatext "false" @default.
- W2922151486 isRetracted "false" @default.
- W2922151486 magId "2922151486" @default.
- W2922151486 workType "article" @default.