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- W2922162594 abstract "The evaluation of the functional capabilities of high-density lipoproteins (HDL) has been shown to be a better predictor of several cardiometabolic diseases than the traditional marker of plasma HDL cholesterol. An important, yet often unconsidered, factor in clinically evaluating HDL function is the method used to purify HDL from plasma. It has been shown that the method of HDL isolation can impact the composition of the HDL produced yet the effect of these compositional changes on HDL function has been explored very little. The evaluation of isolation method is especially important when studying novel HDL functions, such as the vasoprotective functions relevant to Alzheimer’s disease (AD) recently discovered on brain vascular cells and in 3-dimensional brain vessel models. We compared the high-throughput HDL isolation method of polyethylene glycol (PEG) precipitation to the more time-consuming but purer method of sequential density gradient ultracentrifugation (UC) in several of these novel, brain-relevant vasoprotective functions. HDL isolated from young, healthy human plasma by PEG precipitation and UC were equal in their capacity for effluxing cholesterol from macrophages, suppressing TNFα-induced inflammation in brain endothelial cells, and preventing the pathological accumulation of the AD protein amyloid beta (Aβ) in 3D vessel models. However, only HDL isolated by UC, and not PEG precipitation, could induce nitric oxide production and inhibit Aβ-induced inflammation in brain endothelial cells. These findings highlight the importance of HDL isolation method in the composition and function of the HDL produced. Furthermore, that HDL isolation method affected some but not all HDL functions shows that HDL may act on brain vascular cells to protect against AD through more than one pathway." @default.
- W2922162594 created "2019-03-22" @default.
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- W2922162594 date "2018-05-01" @default.
- W2922162594 modified "2023-09-27" @default.
- W2922162594 title "Abstract 385: Ultracentrifugation and Depletion Methods of High-density Lipoprotein Isolation Yield Particles That Are Functionally Distinct in Some of Their Vasoprotective Functions" @default.
- W2922162594 doi "https://doi.org/10.1161/atvb.38.suppl_1.385" @default.
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