FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922173223> ?p ?o ?g. }

• W2922173223 endingPage "H1266" @default.
• W2922173223 startingPage "H1253" @default.
• W2922173223 abstract "Age-related alterations in endothelium and the resulting vascular dysfunction critically contribute to a range of pathological conditions associated with old age. To develop therapies rationally that improve vascular health and thereby increase health span and life span in older adults, it will be essential to understand the cellular and molecular mechanisms contributing to vascular aging. Preclinical studies in model organisms demonstrate that NAD + availability decreases with age in multiple tissues and that supplemental NAD + precursors can ameliorate many age-related cellular impairments. Here, we provide a comprehensive overview of NAD + -dependent pathways [including the NAD + -using silent information regulator-2-like enzymes and poly(ADP-ribose) polymerase enzymes] and the potential consequences of endothelial NAD + deficiency in vascular aging. The multifaceted vasoprotective effects of treatments that reverse the age-related decline in cellular NAD + levels, as well as their potential limitations, are discussed. The preventive and therapeutic potential of NAD + intermediates as effective, clinically relevant interventions in older adults at risk for ischemic heart disease, vascular cognitive impairment, and other common geriatric conditions and diseases that involve vascular pathologies (e.g., sarcopenia, frailty) are critically discussed. We propose that NAD + precursors [e.g., nicotinamide (Nam) riboside, Nam mononucleotide, niacin] should be considered as critical components of combination therapies to slow the vascular aging process and increase cardiovascular health span." @default.
• W2922173223 created "2019-03-22" @default.
• W2922173223 creator A5000383566 @default.
• W2922173223 creator A5008922330 @default.
• W2922173223 creator A5021282382 @default.
• W2922173223 creator A5021351628 @default.
• W2922173223 creator A5027805935 @default.
• W2922173223 creator A5042577204 @default.
• W2922173223 creator A5059163570 @default.
• W2922173223 creator A5088990934 @default.
• W2922173223 date "2019-06-01" @default.
• W2922173223 modified "2023-10-13" @default.
• W2922173223 title "Role of endothelial NAD⁺deficiency in age-related vascular dysfunction" @default.
• W2922173223 cites W1491073804 @default.
• W2922173223 cites W1492660023 @default.
• W2922173223 cites W1498928656 @default.
• W2922173223 cites W1578616085 @default.
• W2922173223 cites W1591200751 @default.
• W2922173223 cites W1785188086 @default.
• W2922173223 cites W1963594829 @default.
• W2922173223 cites W1963982942 @default.
• W2922173223 cites W1965575508 @default.
• W2922173223 cites W1966697917 @default.
• W2922173223 cites W1967635119 @default.
• W2922173223 cites W1972137566 @default.
• W2922173223 cites W1973053270 @default.
• W2922173223 cites W1975259495 @default.
• W2922173223 cites W1976014825 @default.
• W2922173223 cites W1983204064 @default.
• W2922173223 cites W1984222168 @default.
• W2922173223 cites W1986351670 @default.
• W2922173223 cites W1986501172 @default.
• W2922173223 cites W1988179941 @default.
• W2922173223 cites W1988236300 @default.
• W2922173223 cites W1988960591 @default.
• W2922173223 cites W1990826929 @default.
• W2922173223 cites W2002811789 @default.
• W2922173223 cites W2003701712 @default.
• W2922173223 cites W2006496068 @default.
• W2922173223 cites W2006806054 @default.
• W2922173223 cites W2010047125 @default.
• W2922173223 cites W2011386434 @default.
• W2922173223 cites W2012043504 @default.
• W2922173223 cites W2013894613 @default.
• W2922173223 cites W2018138013 @default.
• W2922173223 cites W2018451691 @default.
• W2922173223 cites W2019240387 @default.
• W2922173223 cites W2020304127 @default.
• W2922173223 cites W2021736672 @default.
• W2922173223 cites W2022389789 @default.
• W2922173223 cites W2028159706 @default.
• W2922173223 cites W2038011036 @default.
• W2922173223 cites W2038273086 @default.
• W2922173223 cites W2038391272 @default.
• W2922173223 cites W2039774617 @default.
• W2922173223 cites W2047252577 @default.
• W2922173223 cites W2047538260 @default.
• W2922173223 cites W2048963838 @default.
• W2922173223 cites W2054670968 @default.
• W2922173223 cites W2057563485 @default.
• W2922173223 cites W2057770806 @default.
• W2922173223 cites W2060031886 @default.
• W2922173223 cites W2060814375 @default.
• W2922173223 cites W2062502922 @default.
• W2922173223 cites W2070306500 @default.
• W2922173223 cites W2072502632 @default.
• W2922173223 cites W2074740541 @default.
• W2922173223 cites W2075367810 @default.
• W2922173223 cites W2082393205 @default.
• W2922173223 cites W2087406283 @default.
• W2922173223 cites W2088538972 @default.
• W2922173223 cites W2090442368 @default.
• W2922173223 cites W2093824802 @default.
• W2922173223 cites W2096706830 @default.
• W2922173223 cites W2097750015 @default.
• W2922173223 cites W2098292402 @default.
• W2922173223 cites W2101209889 @default.
• W2922173223 cites W2104035332 @default.
• W2922173223 cites W2104999225 @default.
• W2922173223 cites W2108536847 @default.
• W2922173223 cites W2110720693 @default.
• W2922173223 cites W2110743104 @default.
• W2922173223 cites W2113842550 @default.
• W2922173223 cites W2114215135 @default.
• W2922173223 cites W2115813376 @default.
• W2922173223 cites W2116642215 @default.
• W2922173223 cites W2116743333 @default.
• W2922173223 cites W2117114474 @default.
• W2922173223 cites W2117355848 @default.
• W2922173223 cites W2117662983 @default.
• W2922173223 cites W2118597422 @default.
• W2922173223 cites W2120494123 @default.
• W2922173223 cites W2120499146 @default.
• W2922173223 cites W2122073743 @default.
• W2922173223 cites W2123759854 @default.
• W2922173223 cites W2125114619 @default.
• W2922173223 cites W2125121177 @default.
• W2922173223 cites W2126589850 @default.

• next