FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922173696> ?p ?o ?g. }

• W2922173696 abstract "383 Background: Venous thromboembolism (VTE) is a frequent complication of cancer or its treatment. Khorana (KRS) and Compass scores are two Risk Assessment Models for VTE. However, aUTC was not adequately represented and arterial events were not included, in these models. Methods: Data from pts with aUTC treated with at least one line of chemotherapy in our institution were analyzed. VaTE definition included: DVT and PE defined as venous events and peripheral arterial thrombosis or embolus, ischemic stroke and coronary events, grouped as arterial events. The association of baseline and treatment-related factors with the development of VaTE was assessed using competing-risk regressions. According to the results of our multivariate analysis we stratified patients according to the number of the identified risk factors. Results: 354 aUTC pts treated between 4/1995 and 9/2015 entered our study. 53% of pts had received cisplatin and 42% carboplatin-based regimens. 44 pts (12.4%) suffered 45 VaTEs (13 arterial, 32 venous) within a median time of 3.3 months. The cumulative and 6-month incidence was 14.8% (95% CI: 10.9-19.4) and 9.7% (95% CI: 6.8-13.1), [venous 10.5% (95% CI: 7.3-14.3)/7.5% (95% CI: 5-10.7); arterial 5.3% (95% CI: 2.8-9)/2.7% (95% CI: 1.3-5), respectively]. No association of the KRS and the COMPASS score with the incidence of VaTEs was observed. In the univariate and multivariate analysis, cumulative VaTE incidence was significantly increased in pts with “peripheral arterial disease (PAD) or history of VΤE” (adjusted SHR: 3.29; 95% CI: 1.65-6.55; p=0.001) and pts with other solid tumor (SHR: 2.20; 95% CI: 1.05-4.62; p=0.038). There was a strong correlation between the number of risk factors and the risk for VaTE development (p<0.001). Patients with 1 or 2, vs 0 factors had a 3-fold increased risk [cumulative incidence was 10.9% (95% CI: 7.4.-15.2) and 30.2% (95% CI: 18.4-42.8), respectively; SHR: 3.01 95% CI: 1.65-5.51]. Conclusions: Development of tumor-specific algorithms for the risk of vascular events is supported by our results. Pts with aUTC and a history of VTE, PAD and other solid tumor have a very high risk for VaTE. The role of prophylaxis should be prospectively studied." @default.
• W2922173696 created "2019-03-22" @default.
• W2922173696 creator A5007766504 @default.
• W2922173696 creator A5008426114 @default.
• W2922173696 creator A5012405296 @default.
• W2922173696 creator A5018786046 @default.
• W2922173696 creator A5031109512 @default.
• W2922173696 creator A5045146946 @default.
• W2922173696 creator A5045869380 @default.
• W2922173696 creator A5054809601 @default.
• W2922173696 creator A5059837876 @default.
• W2922173696 creator A5065369868 @default.
• W2922173696 creator A5066877181 @default.
• W2922173696 creator A5067441329 @default.
• W2922173696 creator A5075544808 @default.
• W2922173696 creator A5075922494 @default.
• W2922173696 creator A5076227527 @default.
• W2922173696 creator A5084823180 @default.
• W2922173696 creator A5090241399 @default.
• W2922173696 date "2019-03-01" @default.
• W2922173696 modified "2023-10-18" @default.
• W2922173696 title "Risk for vascular thromboembolic events (VaTEs) in patients (pts) with advanced urinary tract cancer (aUTC) treated with chemotherapy." @default.
• W2922173696 doi "https://doi.org/10.1200/jco.2019.37.7_suppl.383" @default.
• W2922173696 hasPublicationYear "2019" @default.
• W2922173696 type Work @default.
• W2922173696 sameAs 2922173696 @default.
• W2922173696 citedByCount "0" @default.
• W2922173696 crossrefType "journal-article" @default.
• W2922173696 hasAuthorship W2922173696A5007766504 @default.
• W2922173696 hasAuthorship W2922173696A5008426114 @default.
• W2922173696 hasAuthorship W2922173696A5012405296 @default.
• W2922173696 hasAuthorship W2922173696A5018786046 @default.
• W2922173696 hasAuthorship W2922173696A5031109512 @default.
• W2922173696 hasAuthorship W2922173696A5045146946 @default.
• W2922173696 hasAuthorship W2922173696A5045869380 @default.
• W2922173696 hasAuthorship W2922173696A5054809601 @default.
• W2922173696 hasAuthorship W2922173696A5059837876 @default.
• W2922173696 hasAuthorship W2922173696A5065369868 @default.
• W2922173696 hasAuthorship W2922173696A5066877181 @default.
• W2922173696 hasAuthorship W2922173696A5067441329 @default.
• W2922173696 hasAuthorship W2922173696A5075544808 @default.
• W2922173696 hasAuthorship W2922173696A5075922494 @default.
• W2922173696 hasAuthorship W2922173696A5076227527 @default.
• W2922173696 hasAuthorship W2922173696A5084823180 @default.
• W2922173696 hasAuthorship W2922173696A5090241399 @default.
• W2922173696 hasConcept C120665830 @default.
• W2922173696 hasConcept C121332964 @default.
• W2922173696 hasConcept C121608353 @default.
• W2922173696 hasConcept C126322002 @default.
• W2922173696 hasConcept C141071460 @default.
• W2922173696 hasConcept C2776265017 @default.
• W2922173696 hasConcept C2776694085 @default.
• W2922173696 hasConcept C2780011451 @default.
• W2922173696 hasConcept C2780868729 @default.
• W2922173696 hasConcept C61511704 @default.
• W2922173696 hasConcept C71924100 @default.
• W2922173696 hasConcept C72563966 @default.
• W2922173696 hasConcept C88879693 @default.
• W2922173696 hasConceptScore W2922173696C120665830 @default.
• W2922173696 hasConceptScore W2922173696C121332964 @default.
• W2922173696 hasConceptScore W2922173696C121608353 @default.
• W2922173696 hasConceptScore W2922173696C126322002 @default.
• W2922173696 hasConceptScore W2922173696C141071460 @default.
• W2922173696 hasConceptScore W2922173696C2776265017 @default.
• W2922173696 hasConceptScore W2922173696C2776694085 @default.
• W2922173696 hasConceptScore W2922173696C2780011451 @default.
• W2922173696 hasConceptScore W2922173696C2780868729 @default.
• W2922173696 hasConceptScore W2922173696C61511704 @default.
• W2922173696 hasConceptScore W2922173696C71924100 @default.
• W2922173696 hasConceptScore W2922173696C72563966 @default.
• W2922173696 hasConceptScore W2922173696C88879693 @default.
• W2922173696 hasLocation W29221736961 @default.
• W2922173696 hasOpenAccess W2922173696 @default.
• W2922173696 hasPrimaryLocation W29221736961 @default.
• W2922173696 hasRelatedWork W2033096478 @default.
• W2922173696 hasRelatedWork W2113757208 @default.
• W2922173696 hasRelatedWork W2186743950 @default.
• W2922173696 hasRelatedWork W2355902919 @default.
• W2922173696 hasRelatedWork W2412175762 @default.
• W2922173696 hasRelatedWork W2414604045 @default.
• W2922173696 hasRelatedWork W2444461917 @default.
• W2922173696 hasRelatedWork W2591413253 @default.
• W2922173696 hasRelatedWork W2999714152 @default.
• W2922173696 hasRelatedWork W4232664034 @default.
• W2922173696 isParatext "false" @default.
• W2922173696 isRetracted "false" @default.
• W2922173696 magId "2922173696" @default.
• W2922173696 workType "article" @default.