FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922176226> ?p ?o ?g. }

• W2922176226 endingPage "376" @default.
• W2922176226 startingPage "367" @default.
• W2922176226 abstract "The dimorphic fungus Talaromyces marneffei (TM) is a common cause of HIV-associated opportunistic infections in Southeast Asia. Cotrimoxazole (CTX) inhibits folic acid synthesis which is important for the survival of many bacteria, protozoa, and fungi and has been used to prevent several opportunistic infections among HIV/AIDS patients. We question whether CTX is effective in preventing TM infection. To investigate this question, we conducted an 11-year (2005–2016) retrospective observational cohort study of all patients on the Chinese national antiretroviral therapy (ART) programme in Guangxi, a province with high HIV and TM burden in China. Survival analysis was conducted to investigate TM cumulative incidence, and Cox regression and propensity score matching (PSM) were used to evaluate the effect of CTX on TM incidence. Of the 3359 eligible individuals contributing 10,504.66 person-years of follow-up, 81.81% received CTX within 6 months after ART initiation, and 4.73% developed TM infection, contributing 15.14/1,000 person-year TM incidence rate. CTX patients had a significantly lower incidence of TM infection than non-CTX patients (4.11% vs. 7.53%; adjusted hazard ratio (aHR) = 0.50, 95% CI 0.35–0.73). CTX reduced TM incidence in all CD4+ cell subgroups (<50 cells/μL, 50–99 cells/μL, 100–199 cells/μL), with the highest reduction observed in patients with a baseline CD4+ cell count <50 cells/μL in both Cox regression and the PSM analyses. In conclusion, in addition to preventing other HIV-associated opportunistic infections, CTX prophylaxis has the potential to prevent TM infection in HIV/AIDS patients receiving ART." @default.
• W2922176226 created "2019-03-22" @default.
• W2922176226 creator A5003281524 @default.
• W2922176226 creator A5006143345 @default.
• W2922176226 creator A5010674780 @default.
• W2922176226 creator A5013973657 @default.
• W2922176226 creator A5014107541 @default.
• W2922176226 creator A5019786059 @default.
• W2922176226 creator A5021687717 @default.
• W2922176226 creator A5023519876 @default.
• W2922176226 creator A5029741432 @default.
• W2922176226 creator A5032787375 @default.
• W2922176226 creator A5037042475 @default.
• W2922176226 creator A5038084550 @default.
• W2922176226 creator A5046890346 @default.
• W2922176226 creator A5054388151 @default.
• W2922176226 creator A5059212207 @default.
• W2922176226 creator A5060011406 @default.
• W2922176226 creator A5064869771 @default.
• W2922176226 creator A5070008915 @default.
• W2922176226 creator A5070028057 @default.
• W2922176226 creator A5071336437 @default.
• W2922176226 creator A5079855697 @default.
• W2922176226 creator A5087226997 @default.
• W2922176226 creator A5088363022 @default.
• W2922176226 date "2019-01-01" @default.
• W2922176226 modified "2023-10-17" @default.
• W2922176226 title "Effects of cotrimoxazole prophylaxis on <i>Talaromyces marneffei</i> infection in HIV/AIDS patients receiving antiretroviral therapy: a retrospective cohort study" @default.
• W2922176226 cites W1537057087 @default.
• W2922176226 cites W1767940945 @default.
• W2922176226 cites W1775384198 @default.
• W2922176226 cites W1862319760 @default.
• W2922176226 cites W2006975324 @default.
• W2922176226 cites W2011974000 @default.
• W2922176226 cites W2018340707 @default.
• W2922176226 cites W2025390425 @default.
• W2922176226 cites W2040196644 @default.
• W2922176226 cites W2059679437 @default.
• W2922176226 cites W2081757964 @default.
• W2922176226 cites W2091056315 @default.
• W2922176226 cites W2112445000 @default.
• W2922176226 cites W2125340020 @default.
• W2922176226 cites W2149159606 @default.
• W2922176226 cites W2153840871 @default.
• W2922176226 cites W2159324987 @default.
• W2922176226 cites W2162801582 @default.
• W2922176226 cites W2164602415 @default.
• W2922176226 cites W2168990950 @default.
• W2922176226 cites W2171852434 @default.
• W2922176226 cites W2306906732 @default.
• W2922176226 cites W2401708031 @default.
• W2922176226 cites W2558541533 @default.
• W2922176226 cites W2590084954 @default.
• W2922176226 cites W2800419481 @default.
• W2922176226 cites W2808023097 @default.
• W2922176226 cites W4231811370 @default.
• W2922176226 cites W594821081 @default.
• W2922176226 cites W646865264 @default.
• W2922176226 cites W2400499614 @default.
• W2922176226 cites W3029020201 @default.
• W2922176226 doi "https://doi.org/10.1080/22221751.2019.1588078" @default.
• W2922176226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6455230" @default.
• W2922176226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31851879" @default.
• W2922176226 hasPublicationYear "2019" @default.
• W2922176226 type Work @default.
• W2922176226 sameAs 2922176226 @default.
• W2922176226 citedByCount "10" @default.
• W2922176226 countsByYear W29221762262021 @default.
• W2922176226 countsByYear W29221762262022 @default.
• W2922176226 countsByYear W29221762262023 @default.
• W2922176226 crossrefType "journal-article" @default.
• W2922176226 hasAuthorship W2922176226A5003281524 @default.
• W2922176226 hasAuthorship W2922176226A5006143345 @default.
• W2922176226 hasAuthorship W2922176226A5010674780 @default.
• W2922176226 hasAuthorship W2922176226A5013973657 @default.
• W2922176226 hasAuthorship W2922176226A5014107541 @default.
• W2922176226 hasAuthorship W2922176226A5019786059 @default.
• W2922176226 hasAuthorship W2922176226A5021687717 @default.
• W2922176226 hasAuthorship W2922176226A5023519876 @default.
• W2922176226 hasAuthorship W2922176226A5029741432 @default.
• W2922176226 hasAuthorship W2922176226A5032787375 @default.
• W2922176226 hasAuthorship W2922176226A5037042475 @default.
• W2922176226 hasAuthorship W2922176226A5038084550 @default.
• W2922176226 hasAuthorship W2922176226A5046890346 @default.
• W2922176226 hasAuthorship W2922176226A5054388151 @default.
• W2922176226 hasAuthorship W2922176226A5059212207 @default.
• W2922176226 hasAuthorship W2922176226A5060011406 @default.
• W2922176226 hasAuthorship W2922176226A5064869771 @default.
• W2922176226 hasAuthorship W2922176226A5070008915 @default.
• W2922176226 hasAuthorship W2922176226A5070028057 @default.
• W2922176226 hasAuthorship W2922176226A5071336437 @default.
• W2922176226 hasAuthorship W2922176226A5079855697 @default.
• W2922176226 hasAuthorship W2922176226A5087226997 @default.
• W2922176226 hasAuthorship W2922176226A5088363022 @default.
• W2922176226 hasBestOaLocation W29221762261 @default.
• W2922176226 hasConcept C120665830 @default.
• W2922176226 hasConcept C121332964 @default.
• W2922176226 hasConcept C126322002 @default.

• next