Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922179210> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2922179210 abstract "Abstract Background The coumarin group of oral anticoagulants has a narrow therapeutic range and wide inter-individual variability. Polymorphism of VKORC1 and CYP2C9 genes are the major genetic determinants of the drug-dose response. Our study aimed to investigate the role of CYP4F2 (1347 G > A) polymorphism on the acenocoumarol daily dose requirement, and its interaction with VKORC1 and CYP2C9 polymorphism. Methods 301 Rheumatic Heart Disease (RHD) patients with mechanical cardiac valves were recruited. Genotyping for CYP4F2, VKORC1 and CYP2C9 was done by PCR-RFLP. CYP4F2 genotype distribution GG, GA and AA was 23.5%, 51.5% and 25% respectively. The mean daily dose requirement for variant homozygous patients (AA) was 0.46 folds more when compared to wild type (GG) (Adjusted OR 0.46; 0.21–0.99, p = .048). However, on combined genotype analysis of CYP4F2, VKORC1 and CYP2C9 there was no significant difference in mean dose requirement. Conclusion The homozygous genotype (AA) of CYP4F2 gene was more prevalent in our study cohort. No significant association was found between CYP4F2 gene polymorphism and acenocoumarol mean dose requirement, both when analyzed individually and in combination with VKORC1 and CYP2C9 polymorphisms." @default.
- W2922179210 created "2019-03-22" @default.
- W2922179210 creator A5015133574 @default.
- W2922179210 creator A5045897333 @default.
- W2922179210 creator A5053203280 @default.
- W2922179210 creator A5084573339 @default.
- W2922179210 date "2019-06-01" @default.
- W2922179210 modified "2023-09-24" @default.
- W2922179210 title "Significance of CYP4F2 polymorphism on oral anticoagulation therapy with acenocoumarol in South Indian patients with mechanical heart valves" @default.
- W2922179210 cites W1480435942 @default.
- W2922179210 cites W1483996468 @default.
- W2922179210 cites W1510946862 @default.
- W2922179210 cites W1977280638 @default.
- W2922179210 cites W1979299653 @default.
- W2922179210 cites W1993788823 @default.
- W2922179210 cites W1996069708 @default.
- W2922179210 cites W2011476238 @default.
- W2922179210 cites W2016935074 @default.
- W2922179210 cites W2020606753 @default.
- W2922179210 cites W2034506206 @default.
- W2922179210 cites W2039679069 @default.
- W2922179210 cites W2054959248 @default.
- W2922179210 cites W2058187865 @default.
- W2922179210 cites W2059368497 @default.
- W2922179210 cites W2059587305 @default.
- W2922179210 cites W2067701320 @default.
- W2922179210 cites W2117436714 @default.
- W2922179210 cites W2126333303 @default.
- W2922179210 cites W2129122576 @default.
- W2922179210 cites W2144634347 @default.
- W2922179210 cites W2147905647 @default.
- W2922179210 cites W2322622709 @default.
- W2922179210 cites W2469815880 @default.
- W2922179210 doi "https://doi.org/10.1016/j.mgene.2019.100564" @default.
- W2922179210 hasPublicationYear "2019" @default.
- W2922179210 type Work @default.
- W2922179210 sameAs 2922179210 @default.
- W2922179210 citedByCount "0" @default.
- W2922179210 crossrefType "journal-article" @default.
- W2922179210 hasAuthorship W2922179210A5015133574 @default.
- W2922179210 hasAuthorship W2922179210A5045897333 @default.
- W2922179210 hasAuthorship W2922179210A5053203280 @default.
- W2922179210 hasAuthorship W2922179210A5084573339 @default.
- W2922179210 hasConcept C104317684 @default.
- W2922179210 hasConcept C126322002 @default.
- W2922179210 hasConcept C135763542 @default.
- W2922179210 hasConcept C149737253 @default.
- W2922179210 hasConcept C2776301958 @default.
- W2922179210 hasConcept C2776318485 @default.
- W2922179210 hasConcept C2779161974 @default.
- W2922179210 hasConcept C2781344064 @default.
- W2922179210 hasConcept C31467283 @default.
- W2922179210 hasConcept C3946865 @default.
- W2922179210 hasConcept C54355233 @default.
- W2922179210 hasConcept C71924100 @default.
- W2922179210 hasConcept C86803240 @default.
- W2922179210 hasConcept C90924648 @default.
- W2922179210 hasConceptScore W2922179210C104317684 @default.
- W2922179210 hasConceptScore W2922179210C126322002 @default.
- W2922179210 hasConceptScore W2922179210C135763542 @default.
- W2922179210 hasConceptScore W2922179210C149737253 @default.
- W2922179210 hasConceptScore W2922179210C2776301958 @default.
- W2922179210 hasConceptScore W2922179210C2776318485 @default.
- W2922179210 hasConceptScore W2922179210C2779161974 @default.
- W2922179210 hasConceptScore W2922179210C2781344064 @default.
- W2922179210 hasConceptScore W2922179210C31467283 @default.
- W2922179210 hasConceptScore W2922179210C3946865 @default.
- W2922179210 hasConceptScore W2922179210C54355233 @default.
- W2922179210 hasConceptScore W2922179210C71924100 @default.
- W2922179210 hasConceptScore W2922179210C86803240 @default.
- W2922179210 hasConceptScore W2922179210C90924648 @default.
- W2922179210 hasFunder F4320320720 @default.
- W2922179210 hasLocation W29221792101 @default.
- W2922179210 hasOpenAccess W2922179210 @default.
- W2922179210 hasPrimaryLocation W29221792101 @default.
- W2922179210 hasRelatedWork W2007378596 @default.
- W2922179210 hasRelatedWork W2025461698 @default.
- W2922179210 hasRelatedWork W2026741932 @default.
- W2922179210 hasRelatedWork W2046271498 @default.
- W2922179210 hasRelatedWork W2078067001 @default.
- W2922179210 hasRelatedWork W2105892210 @default.
- W2922179210 hasRelatedWork W2109943085 @default.
- W2922179210 hasRelatedWork W2185220959 @default.
- W2922179210 hasRelatedWork W2331494602 @default.
- W2922179210 hasRelatedWork W2381596899 @default.
- W2922179210 hasRelatedWork W2415130461 @default.
- W2922179210 hasRelatedWork W2811016771 @default.
- W2922179210 hasRelatedWork W2905228032 @default.
- W2922179210 hasRelatedWork W2908571360 @default.
- W2922179210 hasRelatedWork W2934719248 @default.
- W2922179210 hasRelatedWork W2946854173 @default.
- W2922179210 hasRelatedWork W3007395470 @default.
- W2922179210 hasRelatedWork W3168355141 @default.
- W2922179210 hasRelatedWork W3191288090 @default.
- W2922179210 hasRelatedWork W2184952596 @default.
- W2922179210 isParatext "false" @default.
- W2922179210 isRetracted "false" @default.
- W2922179210 magId "2922179210" @default.
- W2922179210 workType "article" @default.