FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922185342> ?p ?o ?g. }

• W2922185342 endingPage "746" @default.
• W2922185342 startingPage "735" @default.
• W2922185342 abstract "Oesophagectomy is associated with reduced appetite, weight loss and postprandial hypoglycaemia, the pathophysiological basis of which remains largely unexplored. This study aimed to investigate changes in enteroendocrine function after oesophagectomy.In this prospective study, 12 consecutive patients undergoing oesophagectomy were studied before and 10 days, 6, 12 and 52 weeks after surgery. Serial plasma total fasting ghrelin, and glucagon-like peptide 1 (GLP-1), insulin and glucose release following a standard 400-kcal mixed-meal stimulus were determined. CT body composition and anthropometry were assessed, and symptom scores calculated using European Organisation for Research and Treatment of Cancer (EORTC) questionnaires.At 1 year, two of the 12 patients exhibited postprandial hypoglycaemia, with reductions in bodyweight (mean(s.e.m.) 17·1(3·2) per cent, P < 0·001), fat mass (21.5(2.5) kg versus 25.5(2.4) kg before surgery; P = 0·014), lean body mass (51.5(2.2) versus 54.0(1.8) kg respectively; P = 0·003) and insulin resistance (HOMA-IR: 0.84(0.17) versus 1.16(0.20); P = 0·022). Mean(s.e.m.) fasting ghrelin levels decreased from postoperative day 10, but had recovered by 1 year (preoperative: 621·5(71·7) pg/ml; 10 days: 415·1(59·80) pg/ml; 6 weeks: 309·0(42·0) pg/ml; 12 weeks: 415·8(52·1) pg/ml; 52 weeks: 547·4(83·2) pg/ml; P < 0·001) and did not predict weight loss (P = 0·198). Postprandial insulin increased progressively at 10 days, 6, 12 and 52 weeks (mean(s.e.m.) insulin AUC0-30 min : fold change 1·7(0·4), 2·0(0·4), 3·5(0·7) and 4·0(0·8) respectively; P = 0·001). Postprandial GLP-1 concentration increased from day 10 after surgery (P < 0·001), with a 3·3(1·8)-fold increase at 1 year (P < 0·001). Peak GLP-1 level was inversely associated with the postprandial glucose nadir (P = 0·041) and symptomatic neuroglycopenia (Sigstad score, P = 0·017, R2 = 0·45). GLP-1 AUC predicted loss of weight (P = 0·008, R2 = 0·52) and fat mass (P = 0·010, R2 = 0·64) at 1 year.Altered enteroendocrine physiology is associated with early satiety, weight loss and postprandial hypoglycaemia after oesophagectomy." @default.
• W2922185342 created "2019-03-22" @default.
• W2922185342 creator A5000574895 @default.
• W2922185342 creator A5002215894 @default.
• W2922185342 creator A5010753663 @default.
• W2922185342 creator A5033082307 @default.
• W2922185342 creator A5043990013 @default.
• W2922185342 creator A5048036790 @default.
• W2922185342 creator A5048491760 @default.
• W2922185342 creator A5059738887 @default.
• W2922185342 creator A5079991869 @default.
• W2922185342 date "2019-03-18" @default.
• W2922185342 modified "2023-10-12" @default.
• W2922185342 title "Changes in gut hormones, glycaemic response and symptoms after oesophagectomy" @default.
• W2922185342 cites W1489196940 @default.
• W2922185342 cites W1502442684 @default.
• W2922185342 cites W1798757189 @default.
• W2922185342 cites W1922694287 @default.
• W2922185342 cites W1941160748 @default.
• W2922185342 cites W1963876190 @default.
• W2922185342 cites W1969583687 @default.
• W2922185342 cites W1973960035 @default.
• W2922185342 cites W1987892987 @default.
• W2922185342 cites W1989331518 @default.
• W2922185342 cites W1993163012 @default.
• W2922185342 cites W1999777248 @default.
• W2922185342 cites W2015788437 @default.
• W2922185342 cites W2027893329 @default.
• W2922185342 cites W2035059304 @default.
• W2922185342 cites W2043099990 @default.
• W2922185342 cites W2047187796 @default.
• W2922185342 cites W2058653879 @default.
• W2922185342 cites W2060827148 @default.
• W2922185342 cites W2062073413 @default.
• W2922185342 cites W2069475933 @default.
• W2922185342 cites W2071470362 @default.
• W2922185342 cites W2087600322 @default.
• W2922185342 cites W2101204382 @default.
• W2922185342 cites W2101398993 @default.
• W2922185342 cites W2109326254 @default.
• W2922185342 cites W2111297505 @default.
• W2922185342 cites W2114161811 @default.
• W2922185342 cites W2115072149 @default.
• W2922185342 cites W2124620553 @default.
• W2922185342 cites W2127424726 @default.
• W2922185342 cites W2134703404 @default.
• W2922185342 cites W2154444715 @default.
• W2922185342 cites W2164003190 @default.
• W2922185342 cites W2167571044 @default.
• W2922185342 cites W2278001291 @default.
• W2922185342 cites W2304146082 @default.
• W2922185342 cites W2319854025 @default.
• W2922185342 cites W2412021441 @default.
• W2922185342 cites W2489434422 @default.
• W2922185342 cites W2505149831 @default.
• W2922185342 cites W2531658256 @default.
• W2922185342 cites W2548315011 @default.
• W2922185342 cites W2561646992 @default.
• W2922185342 cites W2599197127 @default.
• W2922185342 cites W2742385777 @default.
• W2922185342 cites W2770898858 @default.
• W2922185342 cites W4317564262 @default.
• W2922185342 cites W807162506 @default.
• W2922185342 doi "https://doi.org/10.1002/bjs.11118" @default.
• W2922185342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30883706" @default.
• W2922185342 hasPublicationYear "2019" @default.
• W2922185342 type Work @default.
• W2922185342 sameAs 2922185342 @default.
• W2922185342 citedByCount "14" @default.
• W2922185342 countsByYear W29221853422019 @default.
• W2922185342 countsByYear W29221853422020 @default.
• W2922185342 countsByYear W29221853422021 @default.
• W2922185342 countsByYear W29221853422022 @default.
• W2922185342 countsByYear W29221853422023 @default.
• W2922185342 crossrefType "journal-article" @default.
• W2922185342 hasAuthorship W2922185342A5000574895 @default.
• W2922185342 hasAuthorship W2922185342A5002215894 @default.
• W2922185342 hasAuthorship W2922185342A5010753663 @default.
• W2922185342 hasAuthorship W2922185342A5033082307 @default.
• W2922185342 hasAuthorship W2922185342A5043990013 @default.
• W2922185342 hasAuthorship W2922185342A5048036790 @default.
• W2922185342 hasAuthorship W2922185342A5048491760 @default.
• W2922185342 hasAuthorship W2922185342A5059738887 @default.
• W2922185342 hasAuthorship W2922185342A5079991869 @default.
• W2922185342 hasBestOaLocation W29221853421 @default.
• W2922185342 hasConcept C126322002 @default.
• W2922185342 hasConcept C134018914 @default.
• W2922185342 hasConcept C188816634 @default.
• W2922185342 hasConcept C2778199505 @default.
• W2922185342 hasConcept C2778345441 @default.
• W2922185342 hasConcept C2779306644 @default.
• W2922185342 hasConcept C2779357093 @default.
• W2922185342 hasConcept C511355011 @default.
• W2922185342 hasConcept C544821477 @default.
• W2922185342 hasConcept C71315377 @default.
• W2922185342 hasConcept C71924100 @default.
• W2922185342 hasConcept C75908981 @default.
• W2922185342 hasConcept C90924648 @default.

• next