FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922198613> ?p ?o ?g. }

• W2922198613 endingPage "297" @default.
• W2922198613 startingPage "291" @default.
• W2922198613 abstract "BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent cancers and microRNAs are involved in colorectal carcinogenesis and progression. The role of our candidate microRNAs (miR-143-3p, -424-5p, -212-3p and -34a-3p) have been investigated in various cancers. OBJECTIVE: The aim of the curre nt study was to evaluate expression levels of microRNAs (miR-143-3p, -424-5p, -212-3p and -34a-3p) in the sera of patients with CRC in order to identify potential non-invasive biomarker for CRC and investigate the relationship between their expression and clinicopathological features of CRC. METHODS: The serological expression of candidate microRNAs were measured in 124 participants, including 62 CRC patients and 62 healthy controls and the serum expression levels of candidate miRNAs were quantified by stemloop reverse transcriptionquantitative polymerase chain reaction. RESULTS: In the present study, results showed a significant upregulation expression level of miR-424-5p (P< 0.001) and decreased expression level of miR143-3p was observed in the sera of patients with CRC (P< 0.001). Receiver operating characteristic (ROC) curve analysis demonstrated the area of miR-424-5p and miR-143-3p under the ROC curve for CRC diagnosis were 0.703 and 0.724 respectively (P< 0.001). In addition, down expression of miR-143-3p was significantly associated with tumor size (P= 0.005) and lymph node metastasis (P= 0.020) in CRC patients. CONCLUSIONS: The present investigation suggested that low expression of miR-143-3p and increasing level of miR-424-5p in CRC patients may play an important role in development of CRC and they could function as potential non-invasive biomarkers for CRC." @default.
• W2922198613 created "2019-03-22" @default.
• W2922198613 creator A5032934517 @default.
• W2922198613 creator A5035314809 @default.
• W2922198613 creator A5044179739 @default.
• W2922198613 date "2019-04-03" @default.
• W2922198613 modified "2023-09-30" @default.
• W2922198613 title "Expression levels of miR-143-3p and -424-5p in colorectal cancer and their clinical significance" @default.
• W2922198613 cites W144423133 @default.
• W2922198613 cites W1499305226 @default.
• W2922198613 cites W1749022239 @default.
• W2922198613 cites W1964416456 @default.
• W2922198613 cites W1983932066 @default.
• W2922198613 cites W1996390519 @default.
• W2922198613 cites W2001113334 @default.
• W2922198613 cites W2004671522 @default.
• W2922198613 cites W2029758324 @default.
• W2922198613 cites W2036607475 @default.
• W2922198613 cites W2039606711 @default.
• W2922198613 cites W2045050188 @default.
• W2922198613 cites W2047146433 @default.
• W2922198613 cites W2048053008 @default.
• W2922198613 cites W2050434028 @default.
• W2922198613 cites W2053003053 @default.
• W2922198613 cites W2088161934 @default.
• W2922198613 cites W2094077020 @default.
• W2922198613 cites W2097233439 @default.
• W2922198613 cites W2099570110 @default.
• W2922198613 cites W2102416115 @default.
• W2922198613 cites W2105632406 @default.
• W2922198613 cites W2111852764 @default.
• W2922198613 cites W2115093090 @default.
• W2922198613 cites W2116799486 @default.
• W2922198613 cites W2122575917 @default.
• W2922198613 cites W2123356446 @default.
• W2922198613 cites W2131811102 @default.
• W2922198613 cites W2138321862 @default.
• W2922198613 cites W2146682817 @default.
• W2922198613 cites W2148419336 @default.
• W2922198613 cites W2160276368 @default.
• W2922198613 cites W2162415186 @default.
• W2922198613 cites W2170552969 @default.
• W2922198613 cites W2513862042 @default.
• W2922198613 cites W2518948144 @default.
• W2922198613 cites W2538990466 @default.
• W2922198613 cites W2746916330 @default.
• W2922198613 cites W2783263674 @default.
• W2922198613 cites W2792493782 @default.
• W2922198613 cites W4211090034 @default.
• W2922198613 doi "https://doi.org/10.3233/cbm-182171" @default.
• W2922198613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30883340" @default.
• W2922198613 hasPublicationYear "2019" @default.
• W2922198613 type Work @default.
• W2922198613 sameAs 2922198613 @default.
• W2922198613 citedByCount "24" @default.
• W2922198613 countsByYear W29221986132019 @default.
• W2922198613 countsByYear W29221986132020 @default.
• W2922198613 countsByYear W29221986132021 @default.
• W2922198613 countsByYear W29221986132022 @default.
• W2922198613 countsByYear W29221986132023 @default.
• W2922198613 crossrefType "journal-article" @default.
• W2922198613 hasAuthorship W2922198613A5032934517 @default.
• W2922198613 hasAuthorship W2922198613A5035314809 @default.
• W2922198613 hasAuthorship W2922198613A5044179739 @default.
• W2922198613 hasConcept C104317684 @default.
• W2922198613 hasConcept C121608353 @default.
• W2922198613 hasConcept C126322002 @default.
• W2922198613 hasConcept C127561419 @default.
• W2922198613 hasConcept C143998085 @default.
• W2922198613 hasConcept C145059251 @default.
• W2922198613 hasConcept C2779013556 @default.
• W2922198613 hasConcept C2781197716 @default.
• W2922198613 hasConcept C48023723 @default.
• W2922198613 hasConcept C502942594 @default.
• W2922198613 hasConcept C526805850 @default.
• W2922198613 hasConcept C55493867 @default.
• W2922198613 hasConcept C555283112 @default.
• W2922198613 hasConcept C58471807 @default.
• W2922198613 hasConcept C63363279 @default.
• W2922198613 hasConcept C71924100 @default.
• W2922198613 hasConcept C86803240 @default.
• W2922198613 hasConceptScore W2922198613C104317684 @default.
• W2922198613 hasConceptScore W2922198613C121608353 @default.
• W2922198613 hasConceptScore W2922198613C126322002 @default.
• W2922198613 hasConceptScore W2922198613C127561419 @default.
• W2922198613 hasConceptScore W2922198613C143998085 @default.
• W2922198613 hasConceptScore W2922198613C145059251 @default.
• W2922198613 hasConceptScore W2922198613C2779013556 @default.
• W2922198613 hasConceptScore W2922198613C2781197716 @default.
• W2922198613 hasConceptScore W2922198613C48023723 @default.
• W2922198613 hasConceptScore W2922198613C502942594 @default.
• W2922198613 hasConceptScore W2922198613C526805850 @default.
• W2922198613 hasConceptScore W2922198613C55493867 @default.
• W2922198613 hasConceptScore W2922198613C555283112 @default.
• W2922198613 hasConceptScore W2922198613C58471807 @default.
• W2922198613 hasConceptScore W2922198613C63363279 @default.
• W2922198613 hasConceptScore W2922198613C71924100 @default.
• W2922198613 hasConceptScore W2922198613C86803240 @default.

• next