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• W2922201963 endingPage "92" @default.
• W2922201963 startingPage "86" @default.
• W2922201963 abstract "To control postoperative pain, a bolus solution of anesthetic drugs is often injected locally, which, however, is limited by short-term drug efficacy and low bioavailability. To resolve this, we propose a composite formulation of bupivacaine-loaded poly(lactic-co-glycolic acid) microparticles (BPC-MPs) and fibrin glue. We prepared the BPC-MPs using the emulsion method and formulated them with fibrin glue to produce FG_BPC-MPs. We performed in vitro drug release experiments for 35 days with the formulations in pH 7.4 phosphate buffered saline (PBS) at 37 ℃. To evaluate in vivo pain-relief efficacy, the pain-induced animals via L5-spinal nerve ligation were treated with FG_BPC-MPs, as well as the control formulations, and the paw withdrawal latency was evaluated with the von Frey filament test. The FG_BPC-MPs exhibited a sustained drug release with a reduced initial burst for up to 35 days. When tested in vivo, a dramatic increase in paw withdrawal threshold was observed during the entire 10-day testing period, suggesting that the pain-relief efficacy was improved and prolonged compared with that for the other control formulations. The FG_BPC-MPs loaded with bupivacaine can be a promising formulation for the treatment of local, persistent pain after surgery." @default.
• W2922201963 created "2019-03-22" @default.
• W2922201963 creator A5024472979 @default.
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• W2922201963 date "2019-07-01" @default.
• W2922201963 modified "2023-10-18" @default.
• W2922201963 title "Poly(lactic-co-glycolic acid) microparticles in fibrin glue for local, sustained delivery of bupivacaine" @default.
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• W2922201963 doi "https://doi.org/10.1016/j.jiec.2019.02.028" @default.
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