Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922205874> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W2922205874 abstract "The study of disease transmission and development of antifungal opposition among Candida species, rapid antifungal susceptibility testing (AFST) is essential for streamlining of antifungal treatment. This investigation was directed to institutionalize a matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI - TOF MS) based AFST strategy (ms- AFST) for helplessness of Candida tropicalis detaches. Clinical secludes of C. tropicalis were affirmed for fluconazole obstruction by the CLSI (M27-A3) strategy. The incubation period and medication concentration were advanced to decide the insignificant profile change concentration (MPCC) by MALDI-TOF MS. The information were broke down first by direct visual perception of the spectra pursued by composite connection list (CCI) matrix investigation, virtual gel investigation, and group examination for affirmation. At long last, the connection between's minimum inhibitory concentrations (MICs) and MPCCs was assessed. A sum of 14 fluconazole resistance (MICs extending from 15 to 127μg/ml) and 18 fluconazole subseptible C. tropicalis segregates (MIC ≤1μg/ml) were incorporated into this examination. All C. tropicalis separates had noteworthy otherworldly changes after 4h concentration with fluconazole. Of 33 confines, MPCCs what's more, MICs were equal for 15 disengages, and the MPCC was one weakening lower than the particular MIC in the rest of the 17 secludes. This finding was additionally upheld by visual investigation, CCI framework examination, virtual gel and chief part examination dendrogram investigation. The relationship among's MPCC and MIC was huge (P <.05). In this way, a MALDI-TOF MS based AFST examine might be utilized as a fast screening procedure for fluconazole against in C. tropicalis.
 Key words: matrix assisted laser desorption ionization-time of flight mass spectrometry, composite correlation index, principal component analysis, Candida tropicalis." @default.
- W2922205874 created "2019-03-22" @default.
- W2922205874 creator A5010263131 @default.
- W2922205874 creator A5088138513 @default.
- W2922205874 date "2019-03-10" @default.
- W2922205874 modified "2023-10-18" @default.
- W2922205874 title "RAPID DETECTION OF FLUCONAZOLE RESISTANCE IN CANDIDA TROPICALIS BY MALDI-TOF-MS" @default.
- W2922205874 doi "https://doi.org/10.32553/ijmbs.v3i3.141" @default.
- W2922205874 hasPublicationYear "2019" @default.
- W2922205874 type Work @default.
- W2922205874 sameAs 2922205874 @default.
- W2922205874 citedByCount "0" @default.
- W2922205874 crossrefType "journal-article" @default.
- W2922205874 hasAuthorship W2922205874A5010263131 @default.
- W2922205874 hasAuthorship W2922205874A5088138513 @default.
- W2922205874 hasBestOaLocation W29222058741 @default.
- W2922205874 hasConcept C176947019 @default.
- W2922205874 hasConcept C185592680 @default.
- W2922205874 hasConcept C2775835631 @default.
- W2922205874 hasConcept C2779548794 @default.
- W2922205874 hasConcept C2780651595 @default.
- W2922205874 hasConcept C43617362 @default.
- W2922205874 hasConcept C501593827 @default.
- W2922205874 hasConcept C86803240 @default.
- W2922205874 hasConcept C89423630 @default.
- W2922205874 hasConceptScore W2922205874C176947019 @default.
- W2922205874 hasConceptScore W2922205874C185592680 @default.
- W2922205874 hasConceptScore W2922205874C2775835631 @default.
- W2922205874 hasConceptScore W2922205874C2779548794 @default.
- W2922205874 hasConceptScore W2922205874C2780651595 @default.
- W2922205874 hasConceptScore W2922205874C43617362 @default.
- W2922205874 hasConceptScore W2922205874C501593827 @default.
- W2922205874 hasConceptScore W2922205874C86803240 @default.
- W2922205874 hasConceptScore W2922205874C89423630 @default.
- W2922205874 hasIssue "3" @default.
- W2922205874 hasLocation W29222058741 @default.
- W2922205874 hasOpenAccess W2922205874 @default.
- W2922205874 hasPrimaryLocation W29222058741 @default.
- W2922205874 hasRelatedWork W1978602955 @default.
- W2922205874 hasRelatedWork W2025173157 @default.
- W2922205874 hasRelatedWork W2069884906 @default.
- W2922205874 hasRelatedWork W2083437972 @default.
- W2922205874 hasRelatedWork W2153445535 @default.
- W2922205874 hasRelatedWork W2369333438 @default.
- W2922205874 hasRelatedWork W2997926091 @default.
- W2922205874 hasRelatedWork W3002725701 @default.
- W2922205874 hasRelatedWork W3047023202 @default.
- W2922205874 hasRelatedWork W4232719764 @default.
- W2922205874 hasVolume "3" @default.
- W2922205874 isParatext "false" @default.
- W2922205874 isRetracted "false" @default.
- W2922205874 magId "2922205874" @default.
- W2922205874 workType "article" @default.