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- W2922207181 abstract "BackgroundEgypt has the highest prevalent in presence of chronic HCV infection that may lead to cirrhosis, portal hypertension, hepatocellular failure and hepatocellular carcinoma. Developing of new drugs in HCV treatment has been developed using direct acting antiviral activity. In this study we assess the safety and efficacy of a combination therapy Sofosbuvir/Simprevir in the treatment of chronic experienced HCVMethodSixty five chronic HCV patients were recruited from the outpatient clinic of Tropical Medicine Department at Fayoum public hospital.A combination of Sofosbuvir (400 mg) and Simeprevir (150 mg) was administered for those patients once daily over a period of 12 weeks. All patients have been followed up for clinical and laboratory parameters and HCV PCR to evaluate the efficacy and safety of this therapy.ResultOur results show high Sustained Virologic Response rate (SVR12) which was 98.5% (64/65). Majority of patients (49.45%) reported adverse events (AEs) during treatment and most common AEs were headache, fatigue, pruritus, dizziness and photosensitivity.ConclusionOn the basis of the evidence currently available, it seems fair to suggest that the combination therapy of (SMV/SOF) in the treatment of chronic HCV genotype IV experienced patient who are non-cirrhotic is safe and effective. This was evidenced by monitoring patients’ clinically and using hepatic parameters after drug administration. The adverse events affected patients were mild and tolerable among patients." @default.
- W2922207181 created "2019-03-22" @default.
- W2922207181 creator A5042032786 @default.
- W2922207181 date "2017-03-01" @default.
- W2922207181 modified "2023-09-27" @default.
- W2922207181 title "REAL LIFE EGYPTIAN EXPERIENCE OF COMBINATION THERAPY (SIMEPREVIR/SOFOSBUVIR) IN EXPERIENCED NON CIRRHOTIC HCV PATIENTS" @default.
- W2922207181 doi "https://doi.org/10.21608/ajps.2017.28414" @default.
- W2922207181 hasPublicationYear "2017" @default.
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