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- W2922209247 abstract "The uptake of sacubitril/valsartan since the PARADIGM study confirmed its beneficial effects on outcomes over enalapril in chronic systolic heart failure has inevitably led to potential interactions with co-prescribed medications in real-world patients. We report two cases that raise the possibility of an interaction between sacubitril/valsartan and the class Ib anti-arrhythmic mexiletine resulting in proarrhythmic effects. We discuss the pharmacokinetics of both agents and posit potential mechanistic interactions that suggest caution should be used and careful monitoring for (ventricular) arrhythmias applied in patients receiving sacubitril/valsartan and mexiletine." @default.
- W2922209247 created "2019-03-22" @default.
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- W2922209247 date "2019-01-01" @default.
- W2922209247 modified "2023-10-16" @default.
- W2922209247 title "Sacubitril/Valsartan and Mexiletine: A Proarrhythmic Combination?" @default.
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- W2922209247 doi "https://doi.org/10.1159/000497071" @default.
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