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• W2922220305 abstract "Abstract Phenylboronic acid-conjugated cationic methylcellulose (MCPEI-PBA) was synthesized and characterized for hepatocellular carcinoma-targeted drug/gene co-delivery systems. MCPEI-PBA was obtained by reductive amination of polyethylenimine 2k to oxidized methylcellulose and conjugation of PBA. MCPEI-PBA could form nano-aggregates via B–N coordinate bonding and hydrophobic interaction and also form positively charged and nano-sized polyplexes. Cytotoxicity of MCPEI-PBA was low and MCPEI-PBA showed higher transfection efficiency than PEI25k in hepatocellular carcinoma. Galactose pretreatment experiment suggested its specific interaction with asialoglycoprotein receptors. MCPEI-PBA could encapsulate doxorubicin (Dox) efficiently. Finally, MCPEI-PBA/Dox/pJDK-apoptin complexes showed high anticancer activity due to the combinatorial effect of Dox and expressed apoptin." @default.
• W2922220305 created "2019-03-22" @default.
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• W2922220305 date "2019-07-01" @default.
• W2922220305 modified "2023-09-26" @default.
• W2922220305 title "Phenylboronic acid-conjugated cationic methylcellulose for hepatocellular carcinoma-targeted drug/gene co-delivery systems" @default.
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• W2922220305 doi "https://doi.org/10.1016/j.jiec.2019.03.016" @default.
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