Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922226154> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2922226154 endingPage "12942" @default.
- W2922226154 startingPage "12937" @default.
- W2922226154 abstract "Abstract The protein inhibitors of activated STAT ( PIAS ) are involved in regulation of many transcription factors and signaling pathways that contribute to the pathogenesis of bipolar disease (BD). In the current study, we evaluated the expression of four PIAS genes ( PIAS1‐4 ) in peripheral blood of BD patients and healthy subjects to explore their contribution in the pathogenesis of BD and their suitability as peripheral biomarkers for this disorder. All PIAS genes were significantly upregulated in total BD patients compared with total controls. The sex‐based analysis confirmed upregulation of PIAS1‐4 genes in male BD patients compared with male controls ( P < 0.001). However, PIAS1 was significantly downregulated in female patients compared with female controls ( P = 0.02). Expression levels of other PIAS genes were not significantly different between female patients and female controls. There were no significant correlations between expression levels of PIAS genes and any of the clinical data of study participants after adjustment of the effects of the sex. On the basis of the area under the curve (AUC) values in receiver operating characteristic curves, PIAS4 had the best performance in the differentiation of disease status between study participants (AUC = 0.81). PIAS3 and PIAS4 genes had the best sensitivity and specificity values, respectively. Combination of expression levels of four genes resulted in the improvement of diagnostic power (AUC = 0.82). The current data implies the role of PIAS genes in the pathogenesis of BD and denotes their suitability as peripheral markers for this disorder." @default.
- W2922226154 created "2019-03-22" @default.
- W2922226154 creator A5036114929 @default.
- W2922226154 creator A5036618678 @default.
- W2922226154 creator A5047593374 @default.
- W2922226154 creator A5083975126 @default.
- W2922226154 creator A5090068547 @default.
- W2922226154 date "2019-03-12" @default.
- W2922226154 modified "2023-10-16" @default.
- W2922226154 title "<i>PIAS</i> genes as disease markers in bipolar disorder" @default.
- W2922226154 cites W100356878 @default.
- W2922226154 cites W1969218281 @default.
- W2922226154 cites W1970925130 @default.
- W2922226154 cites W1983974405 @default.
- W2922226154 cites W1988519696 @default.
- W2922226154 cites W2006485862 @default.
- W2922226154 cites W2016441589 @default.
- W2922226154 cites W2019920814 @default.
- W2922226154 cites W2031584576 @default.
- W2922226154 cites W2039844457 @default.
- W2922226154 cites W2069947776 @default.
- W2922226154 cites W2081341956 @default.
- W2922226154 cites W2115932371 @default.
- W2922226154 cites W2116146198 @default.
- W2922226154 cites W2136087193 @default.
- W2922226154 cites W2156809732 @default.
- W2922226154 cites W2165588484 @default.
- W2922226154 cites W2167038881 @default.
- W2922226154 cites W2170478246 @default.
- W2922226154 cites W2325074909 @default.
- W2922226154 cites W2329541771 @default.
- W2922226154 cites W2898180570 @default.
- W2922226154 cites W4247665917 @default.
- W2922226154 doi "https://doi.org/10.1002/jcb.28564" @default.
- W2922226154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30861611" @default.
- W2922226154 hasPublicationYear "2019" @default.
- W2922226154 type Work @default.
- W2922226154 sameAs 2922226154 @default.
- W2922226154 citedByCount "7" @default.
- W2922226154 countsByYear W29222261542021 @default.
- W2922226154 countsByYear W29222261542022 @default.
- W2922226154 countsByYear W29222261542023 @default.
- W2922226154 crossrefType "journal-article" @default.
- W2922226154 hasAuthorship W2922226154A5036114929 @default.
- W2922226154 hasAuthorship W2922226154A5036618678 @default.
- W2922226154 hasAuthorship W2922226154A5047593374 @default.
- W2922226154 hasAuthorship W2922226154A5083975126 @default.
- W2922226154 hasAuthorship W2922226154A5090068547 @default.
- W2922226154 hasConcept C104317684 @default.
- W2922226154 hasConcept C126322002 @default.
- W2922226154 hasConcept C127561419 @default.
- W2922226154 hasConcept C150194340 @default.
- W2922226154 hasConcept C203014093 @default.
- W2922226154 hasConcept C2779134260 @default.
- W2922226154 hasConcept C2780942790 @default.
- W2922226154 hasConcept C46762472 @default.
- W2922226154 hasConcept C54355233 @default.
- W2922226154 hasConcept C58471807 @default.
- W2922226154 hasConcept C69991583 @default.
- W2922226154 hasConcept C71924100 @default.
- W2922226154 hasConcept C76318530 @default.
- W2922226154 hasConcept C86803240 @default.
- W2922226154 hasConceptScore W2922226154C104317684 @default.
- W2922226154 hasConceptScore W2922226154C126322002 @default.
- W2922226154 hasConceptScore W2922226154C127561419 @default.
- W2922226154 hasConceptScore W2922226154C150194340 @default.
- W2922226154 hasConceptScore W2922226154C203014093 @default.
- W2922226154 hasConceptScore W2922226154C2779134260 @default.
- W2922226154 hasConceptScore W2922226154C2780942790 @default.
- W2922226154 hasConceptScore W2922226154C46762472 @default.
- W2922226154 hasConceptScore W2922226154C54355233 @default.
- W2922226154 hasConceptScore W2922226154C58471807 @default.
- W2922226154 hasConceptScore W2922226154C69991583 @default.
- W2922226154 hasConceptScore W2922226154C71924100 @default.
- W2922226154 hasConceptScore W2922226154C76318530 @default.
- W2922226154 hasConceptScore W2922226154C86803240 @default.
- W2922226154 hasFunder F4320323457 @default.
- W2922226154 hasIssue "8" @default.
- W2922226154 hasLocation W29222261541 @default.
- W2922226154 hasLocation W29222261542 @default.
- W2922226154 hasOpenAccess W2922226154 @default.
- W2922226154 hasPrimaryLocation W29222261541 @default.
- W2922226154 hasRelatedWork W2008911041 @default.
- W2922226154 hasRelatedWork W2051966709 @default.
- W2922226154 hasRelatedWork W2373132269 @default.
- W2922226154 hasRelatedWork W2390926424 @default.
- W2922226154 hasRelatedWork W2392162854 @default.
- W2922226154 hasRelatedWork W2744023513 @default.
- W2922226154 hasRelatedWork W2949466702 @default.
- W2922226154 hasRelatedWork W4237394904 @default.
- W2922226154 hasRelatedWork W49369087 @default.
- W2922226154 hasRelatedWork W3030915957 @default.
- W2922226154 hasVolume "120" @default.
- W2922226154 isParatext "false" @default.
- W2922226154 isRetracted "false" @default.
- W2922226154 magId "2922226154" @default.
- W2922226154 workType "article" @default.