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• W2922230087 endingPage "232" @default.
• W2922230087 startingPage "232" @default.
• W2922230087 abstract "Muscle regeneration, characterized by the activation and proliferation of satellite cells and other precursors, is accompanied by an inflammatory response and the remodeling of the extracellular matrix (ECM), necessary to remove cellular debris and to mechanically support newly generated myofibers and activated satellite cells. Muscle repair can be considered concluded when the tissue architecture, vascularization, and innervation have been restored. Alterations in these connected mechanisms can impair muscle regeneration, leading to the replacement of functional muscle tissue with a fibrotic scar. In the present review, we will discuss the cellular mediators of fibrosis and how the altered expression and secretion of soluble mediators, such as IL-6 and IGF-1, can modulate regulatory networks involved in the altered regeneration and fibrosis during aging and diseases." @default.
• W2922230087 created "2019-03-22" @default.
• W2922230087 creator A5000751018 @default.
• W2922230087 creator A5037361891 @default.
• W2922230087 creator A5048564319 @default.
• W2922230087 creator A5070311407 @default.
• W2922230087 date "2019-03-11" @default.
• W2922230087 modified "2023-10-12" @default.
• W2922230087 title "Signals from the Niche: Insights into the Role of IGF-1 and IL-6 in Modulating Skeletal Muscle Fibrosis" @default.
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