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• W2922230320 abstract "Abstract YtfE, a repair of iron centers protein, plays roles in the response of the bacteria to oxidative and nitrosative stress. The 2.10 Å resolution crystal structure of the isolated Escherichia coli YtfE reveals two‐domain architecture with the L‐shape of a C‐terminal nonheme iron‐containing hemerythrin‐like (Hr‐like) domain linked to an N‐terminal ScdA_N domain via a highly flexible pentapeptide loop. The geometry of the diiron core of YtfE is symmetrical with two five‐coordinate irons. Each iron has a bridging oxygen atom, two bridging carboxylates derived from Glu33/Glu208, and two histidines; His84/His204 are bound to Fe(II) and His129/His160 are bound to Fe(III). Structural analysis of YtfE reveals that the diiron core is connected to the solvent regions by two roughly orthogonal tunnels. Both tunnels have small radii, ranging from 1.2 to 2.4 Å, indicating that the possible substrates (or products) for YtfE are small molecules or ions. The long hydrophobic tunnel can facilitate electron transfer to active site, and the hydrophilic tunnel gated by a negatively glutamate triad may trap proton entry or center iron ion to exit. The mixed‐valence Fe(II)–Fe(III) core of the isolated YtfE bridged by μ‐oxo was characterized by UV–vis, electron paramagnetic resonance (EPR)/electron spin echo envelope modulation (ESEEM) experiments, magnetic circular dichroism (MCD), Mössbauer spectroscopy, resonance Raman, and extended X‐ray absorption fine structure (EXAFS) spectroscopy. In spite of the isolated YtfE exhibiting the Fe(II)–Fe(III) state, the whole‐cell EPR spectrum shows that the YtfE protein exists in the reduced Fe(II)–Fe(II) state under normal cellular conditions. With regard to the repair function, YtfE may act as a ferrous‐ion donor, interacting with IscS or SufS to reassemble the Fe–S cluster of iron–sulfur proteins damaged by oxidative or nitrosative stress. Also, the Fe(II)–Fe(II) core of YtfE serves as an NO‐trapping scavenger to convert NO to N 2 O under the participation of electrons and protons." @default.
• W2922230320 created "2019-03-22" @default.
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• W2922230320 date "2018-06-21" @default.
• W2922230320 modified "2023-10-16" @default.
• W2922230320 title "Iron–Sulfur Cluster Repair Protein<scp>YtfE</scp>" @default.
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• W2922230320 doi "https://doi.org/10.1002/9781119951438.eibc2616" @default.
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