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- W2922234418 abstract "Purpose The development of efficacious tolerance induction therapies will progress when the immunological configuration after heart transplantation (HTx) is known. This study investigated the immunological changes of cell subsets involved in tolerance induction during the first year post-HTx and compared them with long-term HTx (LT-HTx) patients. Methods Blood samples were obtained from n=20 patients prior and at five time points during the first year post-HTx (month 1, 3, 6, 9 and 12) and from n=20 LT-HTx patients which were transplanted at least 5 years and never suffered from rejection. Percentages and mean fluorescence intensities (MFIs) of dendritic cell (DC) and regulatory T cell (Treg) subsets were quantified by flow cytometry. Results Total DCs and CD4+ T cells decreased in the first year post-HTx (Table 1). BDCA1+ (mo 1: 34.5±20.1%, mo 3: 43.4±12.9%, p 0.01) and BDCA3+ (mo 1: 44.2±31.7%, mo 3: 63.3±21.7%, p 0.01). MFIs of CD147, CD120b and CD39 expression in Tregs reduced from month 3 (p Conclusion Tolerance-induction therapies should aim at reinforcing the optimal configuration of DCs and Treg subsets, because these subsets underwent comprehensive changes in the first year post-HTx. Tolerance-inducing therapies should be initiated after regeneration of DC subsets took place in month 3-6 post-HTx." @default.
- W2922234418 created "2019-03-22" @default.
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- W2922234418 date "2019-04-01" @default.
- W2922234418 modified "2023-09-27" @default.
- W2922234418 title "Changes of Immune Cells during the First Post-Transplant Year Guide the Way for Future Tolerance Induction Therapies" @default.
- W2922234418 doi "https://doi.org/10.1016/j.healun.2019.01.627" @default.
- W2922234418 hasPublicationYear "2019" @default.
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