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- W2922242574 endingPage "1808992" @default.
- W2922242574 startingPage "1808992" @default.
- W2922242574 abstract "Poor retention rate, low targeting accuracy, and spontaneous transformation of stem cells present major clinical barriers to the success of therapies based on stem cell transplantation. To improve the clinical outcome, efforts should focus on the active delivery of stem cells to the target tissue site within a controlled environment, increasing survival, and fate for effective tissue regeneration. Here, a remotely steerable microrobotic cell transporter is presented with a biophysically and biochemically recapitulated stem cell niche for directing stem cells towards a pre-destined cell lineage. The magnetically actuated double-helical cell microtransporters of 76 µm length and 20 µm inner cavity diameter are 3D printed where biological and mechanical information regarding the stem cell niche are encoded at the single-cell level. Cell-loaded microtransporters are mobilized inside confined microchannels along computer-controlled trajectories under rotating magnetic fields. The mesenchymal stem cells are shown retaining their differentiation capacities to commit to the osteogenic lineage when stimulated inside the microswimmers in vitro. Such a microrobotic approach has the potential to enable the development of active microcarriers with embedded functionalities for controlled and precisely localized therapeutic cell delivery." @default.
- W2922242574 created "2019-03-22" @default.
- W2922242574 creator A5023244283 @default.
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- W2922242574 creator A5079968392 @default.
- W2922242574 date "2019-03-12" @default.
- W2922242574 modified "2023-10-10" @default.
- W2922242574 title "3D‐Printed Microrobotic Transporters with Recapitulated Stem Cell Niche for Programmable and Active Cell Delivery" @default.
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- W2922242574 doi "https://doi.org/10.1002/adfm.201808992" @default.
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