FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922248744> ?p ?o ?g. }

• W2922248744 endingPage "56" @default.
• W2922248744 startingPage "47" @default.
• W2922248744 abstract "We reported a novel strategy for rapidly and accurately screening biomarkers based on ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) metabolomics data. First, the preliminary variables were obtained by screening the original variables using method validation. Second, the variables were selected from the preliminary variables and formed the variable sets by testing different thresholds of single factor (variable importance in projection (VIP), fold change (FC), the area under the receiver operating characteristic curve (AUROC), and –ln(p-value)). Then the partial least squares-discriminant analysis (PLS-DA) models were performed. The best threshold of each factor, and the corresponding variable set were found by comparing the models' R2X, R2Y, and Q2. Third, the second-step-obtained variable sets were further screened by multi-factors. The best combination of the multi-factors, and the corresponding variable set were found by comparing R2X, R2Y, and Q2. The expected biomarkers were thus obtained. The proposed strategy was successfully applied to screen biomarkers in urine, plasma, hippocampus, and cortex samples of Alzheimer's disease (AD) model, and significantly decreased the time of screening and identifying biomarkers, improved the R2X, R2Y, and Q2, therefore enhanced the interpreting, grouping, and predicting abilities of the PLS-DA model compared with generally-applied procedure. This work can provide a valuable clue to scientists who search for potential biomarkers. It is expected that the developed strategy can be written as a program and applied to screen biomarkers rapidly, efficiently and accurately." @default.
• W2922248744 created "2019-03-22" @default.
• W2922248744 creator A5009590736 @default.
• W2922248744 creator A5015035045 @default.
• W2922248744 creator A5027850301 @default.
• W2922248744 creator A5042696019 @default.
• W2922248744 creator A5068609000 @default.
• W2922248744 creator A5070317590 @default.
• W2922248744 creator A5071300303 @default.
• W2922248744 date "2019-07-01" @default.
• W2922248744 modified "2023-10-17" @default.
• W2922248744 title "A novel strategy for rapidly and accurately screening biomarkers based on ultraperformance liquid chromatography-mass spectrometry metabolomics data" @default.
• W2922248744 cites W1549912426 @default.
• W2922248744 cites W1964353466 @default.
• W2922248744 cites W1972880106 @default.
• W2922248744 cites W1975775976 @default.
• W2922248744 cites W1976416877 @default.
• W2922248744 cites W1985058290 @default.
• W2922248744 cites W1988457908 @default.
• W2922248744 cites W1989393529 @default.
• W2922248744 cites W1997062226 @default.
• W2922248744 cites W1997960038 @default.
• W2922248744 cites W2038544192 @default.
• W2922248744 cites W2040999940 @default.
• W2922248744 cites W2070262574 @default.
• W2922248744 cites W2073503722 @default.
• W2922248744 cites W2077141312 @default.
• W2922248744 cites W2094931894 @default.
• W2922248744 cites W2130395838 @default.
• W2922248744 cites W2195361054 @default.
• W2922248744 cites W2225121000 @default.
• W2922248744 cites W2325106992 @default.
• W2922248744 cites W2504864929 @default.
• W2922248744 cites W2603959463 @default.
• W2922248744 cites W2735998437 @default.
• W2922248744 cites W2770732824 @default.
• W2922248744 cites W2776450307 @default.
• W2922248744 doi "https://doi.org/10.1016/j.aca.2019.03.012" @default.
• W2922248744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30967185" @default.
• W2922248744 hasPublicationYear "2019" @default.
• W2922248744 type Work @default.
• W2922248744 sameAs 2922248744 @default.
• W2922248744 citedByCount "20" @default.
• W2922248744 countsByYear W29222487442019 @default.
• W2922248744 countsByYear W29222487442020 @default.
• W2922248744 countsByYear W29222487442021 @default.
• W2922248744 countsByYear W29222487442022 @default.
• W2922248744 countsByYear W29222487442023 @default.
• W2922248744 crossrefType "journal-article" @default.
• W2922248744 hasAuthorship W2922248744A5009590736 @default.
• W2922248744 hasAuthorship W2922248744A5015035045 @default.
• W2922248744 hasAuthorship W2922248744A5027850301 @default.
• W2922248744 hasAuthorship W2922248744A5042696019 @default.
• W2922248744 hasAuthorship W2922248744A5068609000 @default.
• W2922248744 hasAuthorship W2922248744A5070317590 @default.
• W2922248744 hasAuthorship W2922248744A5071300303 @default.
• W2922248744 hasConcept C119857082 @default.
• W2922248744 hasConcept C134306372 @default.
• W2922248744 hasConcept C153180895 @default.
• W2922248744 hasConcept C154945302 @default.
• W2922248744 hasConcept C162356407 @default.
• W2922248744 hasConcept C177264268 @default.
• W2922248744 hasConcept C182365436 @default.
• W2922248744 hasConcept C185592680 @default.
• W2922248744 hasConcept C199360897 @default.
• W2922248744 hasConcept C21565614 @default.
• W2922248744 hasConcept C22354355 @default.
• W2922248744 hasConcept C33923547 @default.
• W2922248744 hasConcept C41008148 @default.
• W2922248744 hasConcept C43617362 @default.
• W2922248744 hasConcept C58471807 @default.
• W2922248744 hasConcept C69738355 @default.
• W2922248744 hasConceptScore W2922248744C119857082 @default.
• W2922248744 hasConceptScore W2922248744C134306372 @default.
• W2922248744 hasConceptScore W2922248744C153180895 @default.
• W2922248744 hasConceptScore W2922248744C154945302 @default.
• W2922248744 hasConceptScore W2922248744C162356407 @default.
• W2922248744 hasConceptScore W2922248744C177264268 @default.
• W2922248744 hasConceptScore W2922248744C182365436 @default.
• W2922248744 hasConceptScore W2922248744C185592680 @default.
• W2922248744 hasConceptScore W2922248744C199360897 @default.
• W2922248744 hasConceptScore W2922248744C21565614 @default.
• W2922248744 hasConceptScore W2922248744C22354355 @default.
• W2922248744 hasConceptScore W2922248744C33923547 @default.
• W2922248744 hasConceptScore W2922248744C41008148 @default.
• W2922248744 hasConceptScore W2922248744C43617362 @default.
• W2922248744 hasConceptScore W2922248744C58471807 @default.
• W2922248744 hasConceptScore W2922248744C69738355 @default.
• W2922248744 hasFunder F4320321543 @default.
• W2922248744 hasLocation W29222487441 @default.
• W2922248744 hasLocation W29222487442 @default.
• W2922248744 hasOpenAccess W2922248744 @default.
• W2922248744 hasPrimaryLocation W29222487441 @default.
• W2922248744 hasRelatedWork W1967587796 @default.
• W2922248744 hasRelatedWork W2003174742 @default.
• W2922248744 hasRelatedWork W2037752115 @default.
• W2922248744 hasRelatedWork W2047360936 @default.
• W2922248744 hasRelatedWork W2376270290 @default.

• next