Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922262990> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2922262990 abstract "A single transcription factor (TF) potentially induces both threshold and graded transcription responses via super enhancers (SEs) and typical enhancers (TEs). However, the mechanism by which a TF binds to different types of enhancers to determine gene expression quantity remains to be elucidated. To clarify the mechanism, we performed an integrated analysis of chromatin accessibility, RelA-DNA binding and single-cell transcription for each enhancer in anti-IgM-stimulated mouse primary B lymphocytes. Here we show that SE activity, defined by acetylated histone H3 lysine 27 (H3K27Ac) modifications, was simultaneously quantitatively controlled by chromatin opening and enriched RelA binding, resulting in threshold transcription. Our analysis indicated that the number of RelA binding in open chromatin regions at SEs and TEs was on average five and one, respectively, and that a mathematical model having these differences in TF numbers as parameters could explain enhancer-mediated quantitative transcription differences of individual genes. This study indicates that highly specific on-off expression of TF-enriched SE-targeted genes results in a highly selective epigenetic landscape for cell specificity, in contract to broadly responsive TE-regulated genes that may be responsible for cellular homeostasis." @default.
- W2922262990 created "2019-03-22" @default.
- W2922262990 creator A5002937594 @default.
- W2922262990 creator A5016698641 @default.
- W2922262990 creator A5030927963 @default.
- W2922262990 creator A5038251997 @default.
- W2922262990 creator A5045649013 @default.
- W2922262990 creator A5056645736 @default.
- W2922262990 creator A5056981505 @default.
- W2922262990 creator A5064744166 @default.
- W2922262990 creator A5088150244 @default.
- W2922262990 date "2018-01-01" @default.
- W2922262990 modified "2023-10-03" @default.
- W2922262990 title "The Number of Transcription Factor Molecules Loading at an Enhancer Determines Gene Expression Quantity" @default.
- W2922262990 doi "https://doi.org/10.2139/ssrn.3287786" @default.
- W2922262990 hasPublicationYear "2018" @default.
- W2922262990 type Work @default.
- W2922262990 sameAs 2922262990 @default.
- W2922262990 citedByCount "0" @default.
- W2922262990 crossrefType "journal-article" @default.
- W2922262990 hasAuthorship W2922262990A5002937594 @default.
- W2922262990 hasAuthorship W2922262990A5016698641 @default.
- W2922262990 hasAuthorship W2922262990A5030927963 @default.
- W2922262990 hasAuthorship W2922262990A5038251997 @default.
- W2922262990 hasAuthorship W2922262990A5045649013 @default.
- W2922262990 hasAuthorship W2922262990A5056645736 @default.
- W2922262990 hasAuthorship W2922262990A5056981505 @default.
- W2922262990 hasAuthorship W2922262990A5064744166 @default.
- W2922262990 hasAuthorship W2922262990A5088150244 @default.
- W2922262990 hasConcept C104317684 @default.
- W2922262990 hasConcept C111936080 @default.
- W2922262990 hasConcept C138885662 @default.
- W2922262990 hasConcept C150194340 @default.
- W2922262990 hasConcept C153911025 @default.
- W2922262990 hasConcept C179926584 @default.
- W2922262990 hasConcept C21784809 @default.
- W2922262990 hasConcept C41091548 @default.
- W2922262990 hasConcept C41895202 @default.
- W2922262990 hasConcept C54355233 @default.
- W2922262990 hasConcept C64927066 @default.
- W2922262990 hasConcept C83640560 @default.
- W2922262990 hasConcept C86339819 @default.
- W2922262990 hasConcept C86803240 @default.
- W2922262990 hasConcept C95444343 @default.
- W2922262990 hasConceptScore W2922262990C104317684 @default.
- W2922262990 hasConceptScore W2922262990C111936080 @default.
- W2922262990 hasConceptScore W2922262990C138885662 @default.
- W2922262990 hasConceptScore W2922262990C150194340 @default.
- W2922262990 hasConceptScore W2922262990C153911025 @default.
- W2922262990 hasConceptScore W2922262990C179926584 @default.
- W2922262990 hasConceptScore W2922262990C21784809 @default.
- W2922262990 hasConceptScore W2922262990C41091548 @default.
- W2922262990 hasConceptScore W2922262990C41895202 @default.
- W2922262990 hasConceptScore W2922262990C54355233 @default.
- W2922262990 hasConceptScore W2922262990C64927066 @default.
- W2922262990 hasConceptScore W2922262990C83640560 @default.
- W2922262990 hasConceptScore W2922262990C86339819 @default.
- W2922262990 hasConceptScore W2922262990C86803240 @default.
- W2922262990 hasConceptScore W2922262990C95444343 @default.
- W2922262990 hasLocation W29222629901 @default.
- W2922262990 hasOpenAccess W2922262990 @default.
- W2922262990 hasPrimaryLocation W29222629901 @default.
- W2922262990 hasRelatedWork W1964373095 @default.
- W2922262990 hasRelatedWork W1989169142 @default.
- W2922262990 hasRelatedWork W1995372789 @default.
- W2922262990 hasRelatedWork W2051068655 @default.
- W2922262990 hasRelatedWork W2096740813 @default.
- W2922262990 hasRelatedWork W2123434063 @default.
- W2922262990 hasRelatedWork W2132257972 @default.
- W2922262990 hasRelatedWork W2156347973 @default.
- W2922262990 hasRelatedWork W2227578741 @default.
- W2922262990 hasRelatedWork W2415329596 @default.
- W2922262990 hasRelatedWork W2424483111 @default.
- W2922262990 hasRelatedWork W2806835158 @default.
- W2922262990 hasRelatedWork W2970464643 @default.
- W2922262990 hasRelatedWork W2972132308 @default.
- W2922262990 hasRelatedWork W3033164748 @default.
- W2922262990 hasRelatedWork W3049265709 @default.
- W2922262990 hasRelatedWork W3086025261 @default.
- W2922262990 hasRelatedWork W3100166045 @default.
- W2922262990 hasRelatedWork W3116641519 @default.
- W2922262990 hasRelatedWork W3153458134 @default.
- W2922262990 isParatext "false" @default.
- W2922262990 isRetracted "false" @default.
- W2922262990 magId "2922262990" @default.
- W2922262990 workType "article" @default.