FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922272964> ?p ?o ?g. }

• W2922272964 endingPage "12001" @default.
• W2922272964 startingPage "11990" @default.
• W2922272964 abstract "Melanoma accounts for 90% of the deaths associated with cutaneous neoplasms, and the 5-year survival rate of patients with the advanced stage is about 20%. Many mechanisms are involved in melanoma progression, but dynamic epigenetic changes are likely to be critical contributors, especially for DNA methylation. However, we know little about the methylation events involved in melanoma lymph node metastasis (LNM), a deficit that is of particular concern because it has a growing incidence and mortality. To identify DNA methylated-associated changes involved in the formation of metastatic melanoma, we explored the different methylated genes (DMGs) between primary and LNM melanoma by Illumina Human Methylation 450 K BeadArray GSE44661. By integrating DNA methylation and messenger RNA expression data from The Cancer Genome Atlas database, we identified these DNA methylation biomarkers. Pathway analysis highlighted these DMGs, which were closely related to the carcinogenesis of melanoma, such as cell cycle regulation and RNA transcription process. Furthermore, according to the univariate and multivariate Cox regression analysis, we constructed a four-DMG prognostic signature model, which could precisely predict the outcome of melanoma in a more exact way. In summary, this four-DMG based risk score model successfully predicts the survival of melanoma. It is independent of other clinical characteristics and is good for prognosis prediction." @default.
• W2922272964 created "2019-03-22" @default.
• W2922272964 creator A5010500704 @default.
• W2922272964 creator A5013617878 @default.
• W2922272964 creator A5061006889 @default.
• W2922272964 creator A5063550108 @default.
• W2922272964 date "2019-03-12" @default.
• W2922272964 modified "2023-10-15" @default.
• W2922272964 title "Methylation analysis highlights novel prognostic criteria in human‐metastasized melanoma" @default.
• W2922272964 cites W1490559159 @default.
• W2922272964 cites W1755052449 @default.
• W2922272964 cites W1904172445 @default.
• W2922272964 cites W1949370810 @default.
• W2922272964 cites W1966628659 @default.
• W2922272964 cites W1966927188 @default.
• W2922272964 cites W1973605091 @default.
• W2922272964 cites W1985450903 @default.
• W2922272964 cites W1992641070 @default.
• W2922272964 cites W2010527975 @default.
• W2922272964 cites W2016849135 @default.
• W2922272964 cites W2029746613 @default.
• W2922272964 cites W2040753000 @default.
• W2922272964 cites W2055327476 @default.
• W2922272964 cites W2059099579 @default.
• W2922272964 cites W2065498897 @default.
• W2922272964 cites W2066407657 @default.
• W2922272964 cites W2072198806 @default.
• W2922272964 cites W2081527131 @default.
• W2922272964 cites W2090818324 @default.
• W2922272964 cites W2093188241 @default.
• W2922272964 cites W2102118810 @default.
• W2922272964 cites W2106575985 @default.
• W2922272964 cites W2109356985 @default.
• W2922272964 cites W2115738814 @default.
• W2922272964 cites W2121083656 @default.
• W2922272964 cites W2123576451 @default.
• W2922272964 cites W2135707184 @default.
• W2922272964 cites W2137634902 @default.
• W2922272964 cites W2141758639 @default.
• W2922272964 cites W2149793889 @default.
• W2922272964 cites W2161204007 @default.
• W2922272964 cites W2164738877 @default.
• W2922272964 cites W2169977177 @default.
• W2922272964 cites W2320877792 @default.
• W2922272964 cites W2592429207 @default.
• W2922272964 cites W2616928662 @default.
• W2922272964 doi "https://doi.org/10.1002/jcb.28484" @default.
• W2922272964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30861178" @default.
• W2922272964 hasPublicationYear "2019" @default.
• W2922272964 type Work @default.
• W2922272964 sameAs 2922272964 @default.
• W2922272964 citedByCount "2" @default.
• W2922272964 countsByYear W29222729642020 @default.
• W2922272964 countsByYear W29222729642022 @default.
• W2922272964 crossrefType "journal-article" @default.
• W2922272964 hasAuthorship W2922272964A5010500704 @default.
• W2922272964 hasAuthorship W2922272964A5013617878 @default.
• W2922272964 hasAuthorship W2922272964A5061006889 @default.
• W2922272964 hasAuthorship W2922272964A5063550108 @default.
• W2922272964 hasConcept C104317684 @default.
• W2922272964 hasConcept C121608353 @default.
• W2922272964 hasConcept C126322002 @default.
• W2922272964 hasConcept C143998085 @default.
• W2922272964 hasConcept C150194340 @default.
• W2922272964 hasConcept C190727270 @default.
• W2922272964 hasConcept C2777658100 @default.
• W2922272964 hasConcept C33288867 @default.
• W2922272964 hasConcept C41091548 @default.
• W2922272964 hasConcept C502942594 @default.
• W2922272964 hasConcept C50382708 @default.
• W2922272964 hasConcept C54355233 @default.
• W2922272964 hasConcept C555283112 @default.
• W2922272964 hasConcept C60644358 @default.
• W2922272964 hasConcept C71924100 @default.
• W2922272964 hasConcept C86803240 @default.
• W2922272964 hasConceptScore W2922272964C104317684 @default.
• W2922272964 hasConceptScore W2922272964C121608353 @default.
• W2922272964 hasConceptScore W2922272964C126322002 @default.
• W2922272964 hasConceptScore W2922272964C143998085 @default.
• W2922272964 hasConceptScore W2922272964C150194340 @default.
• W2922272964 hasConceptScore W2922272964C190727270 @default.
• W2922272964 hasConceptScore W2922272964C2777658100 @default.
• W2922272964 hasConceptScore W2922272964C33288867 @default.
• W2922272964 hasConceptScore W2922272964C41091548 @default.
• W2922272964 hasConceptScore W2922272964C502942594 @default.
• W2922272964 hasConceptScore W2922272964C50382708 @default.
• W2922272964 hasConceptScore W2922272964C54355233 @default.
• W2922272964 hasConceptScore W2922272964C555283112 @default.
• W2922272964 hasConceptScore W2922272964C60644358 @default.
• W2922272964 hasConceptScore W2922272964C71924100 @default.
• W2922272964 hasConceptScore W2922272964C86803240 @default.
• W2922272964 hasFunder F4320321001 @default.
• W2922272964 hasIssue "7" @default.
• W2922272964 hasLocation W29222729641 @default.
• W2922272964 hasLocation W29222729642 @default.
• W2922272964 hasOpenAccess W2922272964 @default.
• W2922272964 hasPrimaryLocation W29222729641 @default.
• W2922272964 hasRelatedWork W1982470198 @default.

• next