FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922303985> ?p ?o ?g. }

• W2922303985 endingPage "350" @default.
• W2922303985 startingPage "337" @default.
• W2922303985 abstract "Through population-based studies, associations have been found between coffee drinking and numerous health benefits, including a reduced risk of cardiovascular disease. Active ingredients in coffee have therefore received considerable attention from researchers. A wide variety of effects have been attributed to cafestol, one of the major compounds in coffee beans. Because cardiac hypertrophy is an independent risk factor for cardiovascular events, this study examined whether cafestol inhibits urotensin II (U-II)-induced cardiomyocyte hypertrophy. Neonatal rat cardiomyocytes were exposed only to U-II (1[Formula: see text]nM) or to U-II (1[Formula: see text]nM) following 12-h pretreatment with cafestol (1–10[Formula: see text][Formula: see text]M). Cafestol (3–10[Formula: see text][Formula: see text]M) pretreatment significantly inhibited U-II-induced cardiomyocyte hypertrophy with an accompanying decrease in U-II-induced reactive oxygen species (ROS) production. Cafestol also inhibited U-II-induced phosphorylation of redox-sensitive extracellular signal-regulated kinase (ERK) and epidermal growth factor receptor transactivation. In addition, cafestol pretreatment increased Src homology region 2 domains-containing phosphatase-2 (SHP-2) activity, suggesting that cafestol prevents ROS-induced SHP-2 inactivation. Moreover, nuclear factor erythroid-2-related factor 2 (Nrf2) translocation and heme oxygenase-1 (HO-1) expression were enhanced by cafestol. Addition of brusatol (a specific inhibitor of Nrf2) or Nrf2 siRNA significantly attenuated cafestol-mediated inhibitory effects on U-II-stimulated ROS production and cardiomyocyte hypertrophy. In summary, our data indicate that cafestol prevented U-II-induced cardiomycyte hypertrophy through Nrf2/HO-1 activation and inhibition of redox signaling, resulting in cardioprotective effects. These novel findings suggest that cafestol could be applied in pharmacological therapy for cardiac diseases." @default.
• W2922303985 created "2019-03-22" @default.
• W2922303985 creator A5000823185 @default.
• W2922303985 creator A5000936861 @default.
• W2922303985 creator A5002658591 @default.
• W2922303985 creator A5023829039 @default.
• W2922303985 creator A5049193093 @default.
• W2922303985 creator A5077417156 @default.
• W2922303985 date "2019-01-01" @default.
• W2922303985 modified "2023-10-18" @default.
• W2922303985 title "Cafestol Activates Nuclear Factor Erythroid-2 Related Factor 2 and Inhibits Urotensin II-Induced Cardiomyocyte Hypertrophy" @default.
• W2922303985 cites W1574831018 @default.
• W2922303985 cites W2031679289 @default.
• W2922303985 cites W2039483679 @default.
• W2922303985 cites W2043549608 @default.
• W2922303985 cites W2052867135 @default.
• W2922303985 cites W2053357610 @default.
• W2922303985 cites W2087311397 @default.
• W2922303985 cites W210113638 @default.
• W2922303985 cites W2122773218 @default.
• W2922303985 cites W2132068470 @default.
• W2922303985 cites W2137201442 @default.
• W2922303985 cites W2146426188 @default.
• W2922303985 cites W2218478385 @default.
• W2922303985 cites W2418866420 @default.
• W2922303985 cites W2527716629 @default.
• W2922303985 cites W2612582931 @default.
• W2922303985 cites W2625402676 @default.
• W2922303985 cites W2741260051 @default.
• W2922303985 cites W2771044916 @default.
• W2922303985 cites W2771473383 @default.
• W2922303985 cites W2792351106 @default.
• W2922303985 cites W2803089729 @default.
• W2922303985 doi "https://doi.org/10.1142/s0192415x19500162" @default.
• W2922303985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30871360" @default.
• W2922303985 hasPublicationYear "2019" @default.
• W2922303985 type Work @default.
• W2922303985 sameAs 2922303985 @default.
• W2922303985 citedByCount "8" @default.
• W2922303985 countsByYear W29223039852020 @default.
• W2922303985 countsByYear W29223039852022 @default.
• W2922303985 countsByYear W29223039852023 @default.
• W2922303985 crossrefType "journal-article" @default.
• W2922303985 hasAuthorship W2922303985A5000823185 @default.
• W2922303985 hasAuthorship W2922303985A5000936861 @default.
• W2922303985 hasAuthorship W2922303985A5002658591 @default.
• W2922303985 hasAuthorship W2922303985A5023829039 @default.
• W2922303985 hasAuthorship W2922303985A5049193093 @default.
• W2922303985 hasAuthorship W2922303985A5077417156 @default.
• W2922303985 hasConcept C104317684 @default.
• W2922303985 hasConcept C126322002 @default.
• W2922303985 hasConcept C1292079 @default.
• W2922303985 hasConcept C134018914 @default.
• W2922303985 hasConcept C167414201 @default.
• W2922303985 hasConcept C184235292 @default.
• W2922303985 hasConcept C185592680 @default.
• W2922303985 hasConcept C28406088 @default.
• W2922303985 hasConcept C2908647359 @default.
• W2922303985 hasConcept C48349386 @default.
• W2922303985 hasConcept C55493867 @default.
• W2922303985 hasConcept C57074206 @default.
• W2922303985 hasConcept C71924100 @default.
• W2922303985 hasConcept C86339819 @default.
• W2922303985 hasConcept C86803240 @default.
• W2922303985 hasConcept C99454951 @default.
• W2922303985 hasConceptScore W2922303985C104317684 @default.
• W2922303985 hasConceptScore W2922303985C126322002 @default.
• W2922303985 hasConceptScore W2922303985C1292079 @default.
• W2922303985 hasConceptScore W2922303985C134018914 @default.
• W2922303985 hasConceptScore W2922303985C167414201 @default.
• W2922303985 hasConceptScore W2922303985C184235292 @default.
• W2922303985 hasConceptScore W2922303985C185592680 @default.
• W2922303985 hasConceptScore W2922303985C28406088 @default.
• W2922303985 hasConceptScore W2922303985C2908647359 @default.
• W2922303985 hasConceptScore W2922303985C48349386 @default.
• W2922303985 hasConceptScore W2922303985C55493867 @default.
• W2922303985 hasConceptScore W2922303985C57074206 @default.
• W2922303985 hasConceptScore W2922303985C71924100 @default.
• W2922303985 hasConceptScore W2922303985C86339819 @default.
• W2922303985 hasConceptScore W2922303985C86803240 @default.
• W2922303985 hasConceptScore W2922303985C99454951 @default.
• W2922303985 hasIssue "02" @default.
• W2922303985 hasLocation W29223039851 @default.
• W2922303985 hasLocation W29223039852 @default.
• W2922303985 hasOpenAccess W2922303985 @default.
• W2922303985 hasPrimaryLocation W29223039851 @default.
• W2922303985 hasRelatedWork W1518466260 @default.
• W2922303985 hasRelatedWork W1971820552 @default.
• W2922303985 hasRelatedWork W1981654342 @default.
• W2922303985 hasRelatedWork W1993394218 @default.
• W2922303985 hasRelatedWork W1994674353 @default.
• W2922303985 hasRelatedWork W2065161775 @default.
• W2922303985 hasRelatedWork W2078445108 @default.
• W2922303985 hasRelatedWork W2102954760 @default.
• W2922303985 hasRelatedWork W2159629462 @default.
• W2922303985 hasRelatedWork W2388803918 @default.
• W2922303985 hasVolume "47" @default.
• W2922303985 isParatext "false" @default.

• next