Matches in SemOpenAlex for { <https://semopenalex.org/work/W2922322436> ?p ?o ?g. }
- W2922322436 abstract "Abstract Stem cell therapy may replace lost photoreceptors and preserve residual photoreceptors during retinal degeneration (RD). Unfortunately, the degenerative microenvironment compromises the fate of grafted cells, demanding supplementary strategies for microenvironment regulation. Donor cells with both proper regeneration capability and intrinsic ability to improve microenvironment are highly desired. Here, we use cell surface markers (C-Kit + /SSEA4 − ) to effectively eliminate tumorigenic embryonic cells and enrich retinal progenitor cells (RPCs) from human embryonic stem cell (hESC)-derived retinal organoids, which, following subretinal transplantation into RD models of rats and mice, significantly improve vision and preserve the retinal structure. We characterize the pattern of integration and materials transfer following transplantation, which likely contribute to the rescued photoreceptors. Moreover, C-Kit + /SSEA4 − cells suppress microglial activation, gliosis and the production of inflammatory mediators, thereby providing a healthier host microenvironment for the grafted cells and delaying RD. Therefore, C-Kit + /SSEA4 − cells from hESC-derived retinal organoids are a promising therapeutic cell source." @default.
- W2922322436 created "2019-03-22" @default.
- W2922322436 creator A5004635944 @default.
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- W2922322436 date "2019-03-14" @default.
- W2922322436 modified "2023-10-17" @default.
- W2922322436 title "Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents" @default.
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- W2922322436 doi "https://doi.org/10.1038/s41467-019-08961-0" @default.
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